Alison Axtman is a synthetic medicinal chemist with more than 10 years of research experience working at the interface of chemical and biology. Alison earned her PhD in Medicinal Chemistry at the University of Kansas, and carried out her post-doctoral training in the Department of Chemistry at Stanford University. Alison’s research has focused on the synthesis of small molecules that selectively modulate proteins implicated in disease-propagating pathways. As a member of the GSK Chemical Biology department, she led a program to understand the molecular basis of immune modulation by a class of natural products and developed analogs with improved drug properties. Alison is currently a Research Assistant Professor in the Chemical Biology and Medicinal Chemistry Department in the UNC Eshelman School of Pharmacy. At the SGC-UNC, she leads the design of novel chemical probes for understudied protein kinases that will be openly shared with collaborators to facilitate target discovery in human disease-relevant assays. When she’s not in the lab, Alison can be most often found at the gym preparing for the next CrossFit or GRID competition with her teammates.
Binder MJ, Bashore FM, Dunn Hoffman KK, Damgaard C, Slater M, Drewry DH, Robers MB, Axtman AD
J Med Chem. 2026-2-7 . .doi: 10.1021/acs.jmedchem.5c02916
PMID: 41651452Capener JL, Kramer TW, Bashore FM, Flory E, Li F, Strang BL, Axtman AD
J Med Chem. 2026-1-26 . .doi: 10.1021/acs.jmedchem.5c02609
PMID: 41587072Capener JL, Schwalm MP, Vasta JD, Michaud A, Teske KA, Marsiglia WM, Huber KVM, Dar AC, Knapp S, Axtman AD, Robers MB
Nat Chem Biol. 2026-1-7 . .doi: 10.1038/s41589-025-02103-y
PMID: 41495225Yang T, Huhe H, Williams SP, Kaur S, Ay YA, Davis-Gilbert ZW, Cary GA, Paisie C, Butler RR 3rd, Wiley J, Betarbet R, Fu H, Duong D, Seyfried NT, Leal K, Carter GW, Edwards A, Levey AI, Capener JL, Drewry DH, Hossain MA, Oh HJ, Axtman AD, Sukoff Rizzo SJ, Longo FM
Alzheimers Dement. 2025-12-26 . 21(12):e71033 .doi: 10.1002/alz.71033
PMID: 41451871Maiti A, Axtman AD, Wu R, Redman LJB, Takabe K, Stablewski AB, Yan L, Ciesielski MJ, Zhang J, Evans SS, Kalinski P, Hait NC
Sci Rep. 2025-11-19 . 15(1):40651 .doi: 10.1038/s41598-025-24354-4
PMID: 41258112Min SM, Bashore FM, Smith JL, Havener TM, Howell S, Li H, Couñago RM, Popov KI, Axtman AD
J Med Chem. 2025-1-22 . .doi: 10.1021/acs.jmedchem.4c02531
PMID: 39838960Leal K, Axtman AD, Betarbet R, Brennan PE, Carter GW, Fu H, Greenwood AK, Longo FM, Edwards AM, Levey AI, Center ET
Alzheimers Dement. 2025-1-9 . 20 Suppl 6:e089250 .doi: 10.1002/alz.089250
PMID: 39782659Rodríguez-Palma EJ, Loya-Lopez S, Min SM, Calderon-Rivera A, Gomez K, Khanna R, Axtman AD
Neurobiol Pain. 2024-12-25 . 17:100174 .doi: 10.1016/j.ynpai.2024.100174
PMID: 39720155Ong HW, Yang X, Smith JL, Taft-Benz S, Howell S, Dickmander RJ, Havener TM, Sanders MK, Brown JW, Couñago RM, Chang E, Krämer A, Moorman NJ, Heise M, Axtman AD, Drewry DH, Willson TM
Molecules. 2024-9-14 . 29(17): .doi: 10.3390/molecules29174158
PMID: 39275006Bashore FM, Min SM, Chen X, Howell S, Rinderle CH, Morel G, Silvaroli JA, Wells CI, Bunnell BA, Drewry DH, Pabla NS, Ultanir SK, Bullock AN, Axtman AD
ACS Med Chem Lett. 2024-8-8 . 15(8):1325-1333 .doi: 10.1021/acsmedchemlett.4c00219
PMID: 39140040