Alison Axtman is a synthetic medicinal chemist with more than 10 years of research experience working at the interface of chemical and biology. Alison earned her PhD in Medicinal Chemistry at the University of Kansas, and carried out her post-doctoral training in the Department of Chemistry at Stanford University. Alison’s research has focused on the synthesis of small molecules that selectively modulate proteins implicated in disease-propagating pathways. As a member of the GSK Chemical Biology department, she led a program to understand the molecular basis of immune modulation by a class of natural products and developed analogs with improved drug properties. Alison is currently a Research Assistant Professor in the Chemical Biology and Medicinal Chemistry Department in the UNC Eshelman School of Pharmacy. At the SGC-UNC, she leads the design of novel chemical probes for understudied protein kinases that will be openly shared with collaborators to facilitate target discovery in human disease-relevant assays. When she’s not in the lab, Alison can be most often found at the gym preparing for the next CrossFit or GRID competition with her teammates.
Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X, Wells C, Willson TM, Frye SV, Young JE, Axtman AD
Alzheimers Dement (N Y). 2022-4-19 . 8(1):e12253 .doi: 10.1002/trc2.12253
PMID: 35434254Potjewyd FM, Axtman AD
Front Cell Neurosci. 2021-12-7 . 15:768655 .doi: 10.3389/fncel.2021.768655
PMID: 34867205Axtman AD
Biochim Biophys Acta Gen Subj. 2021-9-18 . 130014 .doi: 10.1016/j.bbagen.2021.130014
PMID: 34547390Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, Mathea S, Axtman AD
J Med Chem. 2021-8-1 . .doi: 10.1021/acs.jmedchem.1c00440
PMID: 34333981Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD
Cell Chem Biol. 2021-1-11 . .doi: 10.1016/j.chembiol.2020.12.013
PMID: 33484635Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM, Drewry DH
Int J Mol Sci. 2021-1-8 . 22(2): .doi: 10.3390/ijms22020566
PMID: 33429995Wang CB, Lorente-Macías Á, Wells C, Pickett JE, Picado A, Zuercher WJ, Axtman AD
RSC Med Chem. 2021-1-1 . 12(1):129-136 .doi: 10.1039/d0md00292e
PMID: 34046605Tamir TY, Drewry DH, Wells C, Major MB, Axtman AD
Sci Rep. 2020-9-28 . 10(1):15826 .doi: 10.1038/s41598-020-72869-9
PMID: 32985588Lindsley CW, Axtman AD
ACS Chem Neurosci. 2020-9-16 . 11(18):2783-2785 .doi: 10.1021/acschemneuro.0c00548
PMID: 32933260Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD
ACS Chem Neurosci. 2020-5-28 . .doi: 10.1021/acschemneuro.0c00176
PMID: 32464049