Publications

You can search the extensive SGC publications list with keywords from the title, authors or journal name. Your search results can be exported to an Excel file by clicking the orange XLS button next to the search filters

2018

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CR

Proc. Natl. Acad. Sci. U.S.A.. doi: 10.1073/pnas.1810498115

Publication date: August 27, 2018

PMID: 30150413

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ

Nat Commun. 9(1):3411. doi: 10.1038/s41467-018-05646-y

Publication date: August 24, 2018

PMID: 30143613

Architecture of the native major royal jelly protein 1 oligomer.

Tian W, Li M, Guo H, Peng W, Xue X, Hu Y, Liu Y, Zhao Y, Fang X, Wang K, Li X, Tong Y, Conlon MA, Wu W, Ren F, Chen Z

Nat Commun. 9(1):3373. doi: 10.1038/s41467-018-05619-1

Publication date: August 22, 2018

PMID: 30135511

NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.

Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S, Kuster B, Médard G, Kudlinzki D, Schwalbe H

ChemMedChem. 13(16):1629-1633. doi: 10.1002/cmdc.201800398

Publication date: August 20, 2018

PMID: 29928781

Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains.

Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS

ACS Chem. Biol.. doi: 10.1021/acschembio.7b00638

Publication date: August 13, 2018

PMID: 30102854

Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept.

Hudson L, Mui J, Vázquez S, Carvalho DM, Williams E, Jones C, Bullock AN, Hoelder S

J. Med. Chem.. doi: 10.1021/acs.jmedchem.8b00782

Publication date: August 7, 2018

PMID: 30085668

Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as Dual Inhibitors of Discoidin Domain Receptor 1 and 2 (DDR1/2).

Wang Z, Zhang Y, Pinkas D, Fox A, Luo J, Huang H, Cui S, Xiang Q, Xu T, Xun Q, Zhu D, Tu ZC, Ren X, Brekken RA, Bullock AN, Liang G, Ding K, Lu X

J. Med. Chem.. doi: 10.1021/acs.jmedchem.8b01045

Publication date: August 3, 2018

PMID: 30075624

GW779439X and its pyrazolopyridazine derivatives inhibit the serine/threonine kinase Stk1 and act as antibiotic adjuvants against β-lactam-resistant Staphylococcus aureus.

Schaenzer AJ, Wlodarchak N, Drewry D, Zuercher WJ, Rose WE, Ferrer CA, Sauer JD, Striker R

ACS Infect Dis. doi: 10.1021/acsinfecdis.8b00136

Publication date: July 30, 2018

PMID: 30059625

The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.

Gao X, Xie H, Zhu S, Yu B, Xian Y, Ouyang Q, Ji Y, Yang X, Wen C, Wang P, Tong Y, Wang Q

Front Aging Neurosci. 10:196. doi: 10.3389/fnagi.2018.00196

Publication date: July 28, 2018

PMID: 30050428

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.

Strang BL, Asquith CRM, Moshrif HF, Ho CM, Zuercher WJ, Al-Ali H

PLoS ONE. 13(7):e0201321. doi: 10.1371/journal.pone.0201321

Publication date: July 27, 2018

PMID: 30048526

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M

EMBO J.. doi: 10.15252/embj.201899372

Publication date: July 19, 2018

PMID: 30026309

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.

Fox NG, Martelli A, Nabhan JF, Janz J, Borkowska O, Bulawa C, Yue WW

Biochimie. doi: 10.1016/j.biochi.2018.07.012

Publication date: July 19, 2018

PMID: 30031876

Chemoproteomics and Chemical Probes for Target Discovery.

Drewes G, Knapp S

Trends Biotechnol.. doi: 10.1016/j.tibtech.2018.06.008

Publication date: July 12, 2018

PMID: 30017093

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

Bonday ZQ, Cortez GS, Grogan MJ, Antonysamy S, Weichert K, Bocchinfuso WP, Li F, Kennedy S, Li B, Mader MM, Arrowsmith CH, Brown PJ, Eram MS, Szewczyk MM, Barsyte-Lovejoy D, Vedadi M, Guccione E, Campbell RM

ACS Med Chem Lett. 9(7):612-617. doi: 10.1021/acsmedchemlett.8b00014

Publication date: July 12, 2018

PMID: 30034588

A TFEB nuclear export signal integrates amino acid supply and glucose availability.

Li L, Friedrichsen HJ, Andrews S, Picaud S, Volpon L, Ngeow K, Berridge G, Fischer R, Borden KLB, Filippakopoulos P, Goding CR

Nat Commun. 9(1):2685. doi: 10.1038/s41467-018-04849-7

Publication date: July 11, 2018

PMID: 29992949

SATurn: A modular bioinformatics framework for the design of robust maintainable web-based and standalone applications.

Damerell DR, Strain-Damerell C, Garsot S, Joyce S, Barrett P, Marsden BD

Bioinformatics. doi: 10.1093/bioinformatics/bty549

Publication date: July 4, 2018

PMID: 29982288

Targeting Pim Kinases and DAPK3 to Control Hypertension.

Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ

Cell Chem Biol. doi: 10.1016/j.chembiol.2018.06.006

Publication date: July 4, 2018

PMID: 30033129

Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9.

Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T

J. Biol. Chem.. doi: 10.1074/jbc.RA118.002890

Publication date: June 29, 2018

PMID: 29959229

A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides.

Wright M, Martinez-Lamenca C, Leenaerts JE, Brennan PE, Trabanco AA, Oehlrich D

J. Org. Chem.. doi: 10.1021/acs.joc.8b01244

Publication date: June 22, 2018

PMID: 29932332

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2- O -sulphotransferase (HS2ST) is a target for small molecule protein kinase inhibitors.

Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Lu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA

Biochem. J.. doi: 10.1042/BCJ20180265

Publication date: June 22, 2018

PMID: 29934491

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.

Byrne DP, Li Y, Ngamlert P, Ramakrishnan K, Eyers CE, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA

Biochem. J.. doi: 10.1042/BCJ20180266

Publication date: June 22, 2018

PMID: 29934490

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.

Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R

J. Cell Biol.. doi: 10.1083/jcb.201804042

Publication date: June 19, 2018

PMID: 29921600

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.

Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW

Nat Commun. 9(1):2261. doi: 10.1038/s41467-018-04735-2

Publication date: June 11, 2018

PMID: 29891918

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes.

Oerum S, Roovers M, Rambo RP, Kopec J, Bailey HJ, Fitzpatrick F, Newman JA, Newman WG, Amberger A, Zschocke J, Droogmans L, Oppermann U, Yue WW

J. Biol. Chem.. doi: 10.1074/jbc.RA117.001286

Publication date: June 7, 2018

PMID: 29880640

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

Favalli N, Biendl S, Hartmann M, Piazzi J, Sladojevich F, Gräslund S, Brown PJ, Näreoja K, Schüler H, Scheuermann J, Franzini R, Neri D

ChemMedChem. doi: 10.1002/cmdc.201800193

Publication date: June 1, 2018

PMID: 29856130

Development, Optimization and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4-d]pyrrolo[2,3-b]pyridine Scaffold.

Forster M, Chaikuad A, Dimitrov T, Döring E, Holstein J, Berger BT, Gehringer M, Ghoreschi K, Müller S, Knapp S, Laufer SA

J. Med. Chem.. doi: 10.1021/acs.jmedchem.8b00571

Publication date: May 31, 2018

PMID: 29852068

What Is the BET on Solid Tumors?

Filippakopoulos P

J. Clin. Oncol.. JCO2018788695. doi: 10.1200/JCO.2018.78.8695

Publication date: May 30, 2018

PMID: 29847297

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.

Spear ED, Hsu ET, Nie L, Carpenter EP, Hrycyna CA, Michaelis S

Dis Model Mech. doi: 10.1242/dmm.033670

Publication date: May 24, 2018

PMID: 29794150

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.

Fulcher LJ, Bozatzi P, Tachie-Menson T, Wu KZL, Cummins TD, Bufton JC, Pinkas DM, Dunbar K, Shrestha S, Wood NT, Weidlich S, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Dingwell KS, Smith JC, Bullock AN, Sapkota GP

Sci Signal. 11(531):. doi: 10.1126/scisignal.aao2341

Publication date: May 22, 2018

PMID: 29789297

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

Asquith CRM, Godoi PH, Couñago RM, Laitinen T, Scott JW, Langendorf CG, Oakhill JS, Drewry DH, Zuercher WJ, Koutentis PA, Willson TM, Kalogirou AS

Molecules. 23(5):. doi: 10.3390/molecules23051221

Publication date: May 19, 2018

PMID: 29783765

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ

Bioorg. Med. Chem.. doi: 10.1016/j.bmc.2018.05.003

Publication date: May 15, 2018

PMID: 29776834

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.

Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang CH, Butler MO, Arrowsmith CH, Hirano N

Nat Commun. 9(1):1915. doi: 10.1038/s41467-018-04262-0

Publication date: May 15, 2018

PMID: 29765028

Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.

Ferreira de Freitas R, Harding RJ, Franzoni I, Ravichandran M, Mann MK, Ouyang H, Lautens M, Santhakumar V, Arrowsmith CH, Schapira M

J. Med. Chem.. doi: 10.1021/acs.jmedchem.8b00258

Publication date: May 9, 2018

PMID: 29741882

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

Walter A, Chaikuad A, Helmer R, Loaëc N, Preu L, Ott I, Knapp S, Meijer L, Kunick C

PLoS ONE. 13(5):e0196761. doi: 10.1371/journal.pone.0196761

Publication date: May 4, 2018

PMID: 29723265

Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth.

Krulikas LJ, McDonald IM, Lee B, Okumu DO, East MP, Gilbert TSK, Herring LE, Golitz BT, Wells CI, Axtman AD, Zuercher WJ, Willson TM, Kireev D, Yeh JJ, Johnson GL, Baines AT, Graves LM

SLAS Discov. 2472555218773045. doi: 10.1177/2472555218773045

Publication date: May 1, 2018

PMID: 29742358

The C-terminal extension landscape of naturally presented HLA-I ligands.

Guillaume P, Picaud S, Baumgaertner P, Montandon N, Schmidt J, Speiser DE, Coukos G, Bassani-Sternberg M, Filippakopoulos P, Gfeller D

Proc. Natl. Acad. Sci. U.S.A.. doi: 10.1073/pnas.1717277115

Publication date: April 30, 2018

PMID: 29712860

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A

Elife. 7:. doi: 10.7554/eLife.34311

Publication date: April 20, 2018

PMID: 29676732

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.

Valleau D, Quaile AT, Cui H, Xu X, Evdokimova E, Chang C, Cuff ME, Urbanus ML, Houliston S, Arrowsmith CH, Ensminger AW, Savchenko A

Cell Rep. 23(2):568-583. doi: 10.1016/j.celrep.2018.03.060

Publication date: April 10, 2018

PMID: 29642013

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.

Dong C, Zhang H, Li L, Tempel W, Loppnau P, Min J

Nat. Chem. Biol.. doi: 10.1038/s41589-018-0036-1

Publication date: April 9, 2018

PMID: 29632410

A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms.

Johnson SR, McGown I, Oppermann U, Conwell LS, Harris M, Duncan EL

Pediatr Diabetes. doi: 10.1111/pedi.12679

Publication date: April 6, 2018

PMID: 29633446

Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.

Harding RJ, Tong YF

Acta Pharmacol Sin. 39(5):754-769. doi: 10.1038/aps.2018.11

Publication date: April 6, 2018

PMID: 29620053

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.

Nakayama K, Szewczyk MM, Dela Sena C, Wu H, Dong A, Zeng H, Li F, de Freitas RF, Eram MS, Schapira M, Baba Y, Kunitomo M, Cary DR, Tawada M, Ohashi A, Imaeda Y, Saikatendu KS, Grimshaw CE, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, Kiba A, Tomita D, Brown PJ

Oncotarget. 9(26):18480-18493. doi: 10.18632/oncotarget.24883

Publication date: April 6, 2018

PMID: 29719619

Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo.

Aldeghi M, Ross GA, Bodkin MJ, Essex JW, Knapp S, Biggin PC

Commun Chem. 1:. doi: 10.1038/s42004-018-0019-x

Publication date: April 5, 2018

PMID: 29863194

A Pseudo-Kinase Double Act.

Preuß F, Mathea S, Knapp S

Structure. 26(4):527-528. doi: 10.1016/j.str.2018.03.008

Publication date: April 3, 2018

PMID: 29617648

Halogen-aromatic π-interactions modulate inhibitor residence time.

Heroven C, Georgi V, Ganotra GK, Brennan PE, Wolfreys F, Wade RC, Fernández-Montalván AE, Chaikuad A, Knapp S

Angew. Chem. Int. Ed. Engl.. doi: 10.1002/anie.201801666

Publication date: March 30, 2018

PMID: 29601130

Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces.

Brennan P, Bowkett D, Talon R, Tallant C, Schofield C, Bruton G, von Delft F, Knapp S

ChemMedChem. doi: 10.1002/cmdc.201800030

Publication date: March 26, 2018

PMID: 29578648

Therapeutics discovery: From bench to first in-human trials.

Al-Hujaily EM, Khatlani T, Alehaideb Z, Ali R, Almuzaini B, Alrfaei BM, Iqbal J, Islam I, Malik S, Marwani BA, Massadeh S, Nehdi A, Alsomaie B, Debasi B, Bushnak I, Noibi S, Hussain S, Wajid WA, Armand JP, Gul S, Oyarzabal J, Rais R, Bountra C, Alaskar A, Knawy BA, Boudjelal M

Biomed Rep. 8(3):275-282. doi: 10.3892/br.2018.1052

Publication date: March 23, 2018

PMID: 29564125

Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.

Liu K, Xu C, Lei M, Yang A, Loppnau P, Hughes TR, Min J

J. Biol. Chem.. doi: 10.1074/jbc.RA118.001785

Publication date: March 22, 2018

PMID: 29567833

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.

Zhang H, Zhou B, Qin S, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min J

Genes Dev.. doi: 10.1101/gad.311639.118

Publication date: March 21, 2018

PMID: 29563185

Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1, TAF1.

Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV

Biochemistry. doi: 10.1021/acs.biochem.8b00150

Publication date: March 20, 2018

PMID: 29558110

Displaying 801 - 850 of 1839
Download XLS