Publications | Structural Genomics Consortium

Korczynska M, Le DD, Younger N, Gregori-Puigjané E, Tumber A, Krojer T, Velupillai S, Gileadi C, Nowak RP, Iwasa E, Pollock SB, Ortiz Torres I, Oppermann U, Shoichet BK, Fujimori DG

J. Med. Chem.. doi: 10.1021/acs.jmedchem.5b01527

Publication date: December 23, 2015

PMID: 26699912

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.

Yanling Zhao D, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JF

Nature. doi: 10.1038/nature16469

Publication date: December 23, 2015

PMID: 26700805

Role of reverse phenotyping in interpretation of next generation sequencing data and a review of INPP5E related disorders.

de Goede C, Yue WW, Yan G, Ariyaratnam S, Chandler KE, Downes L, Khan N, Mohan M, Lowe M, Banka S

Eur. J. Paediatr. Neurol.. doi: 10.1016/j.ejpn.2015.11.012

Publication date: December 18, 2015

PMID: 26748598

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Riemersma M, Froese DS, van Tol W, Engelke UF, Kopec J, van Scherpenzeel M, Ashikov A, Krojer T, von Delft F, Tessari M, Buczkowska A, Swiezewska E, Jae LT, Brummelkamp TR, Manya H, Endo T, van Bokhoven H, Yue WW, Lefeber DJ

Chem. Biol.. 22(12):1643-52. doi: 10.1016/j.chembiol.2015.10.014

Publication date: December 17, 2015

PMID: 26687144

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

Newman JA, Cooper CD, Aitkenhead H, Gileadi O

Structure. 23(12):2319-30. doi: 10.1016/j.str.2015.10.014

Publication date: December 1, 2015

PMID: 26636256

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.

Dixon-Clarke SE, Elkins JM, Cheng SW, Morin GB, Bullock AN

Sci Rep. 5:17122. doi: 10.1038/srep17122

Publication date: November 26, 2015

PMID: 26597175

Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.

Davydov R, Strushkevich N, Smil D, Yantsevich A, Gilep A, Usanov S, Hoffman BM

Biochemistry. doi: 10.1021/acs.biochem.5b00903

Publication date: November 25, 2015

PMID: 26603348

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, Sturm D, Kushida MM, Head R, Cusimano MD, Bernstein M, Clarke ID, Dick JE, Pfister SM, Rich JN, Arrowsmith CH, Taylor MD, Jabado N, Bazett-Jones DP, Lupien M, Dirks PB

Cancer Cell. doi: 10.1016/j.ccell.2015.10.005

Publication date: November 25, 2015

PMID: 26626085

A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J

ACS Chem. Biol.. doi: 10.1021/acschembio.5b00839

Publication date: November 24, 2015

PMID: 26598975

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins.

Kamps JJ, Huang J, Poater J, Xu C, Pieters BJ, Dong A, Min J, Sherman W, Beuming T, Matthias Bickelhaupt F, Li H, Mecinović J

Nat Commun. 6:8911. doi: 10.1038/ncomms9911

Publication date: November 19, 2015

PMID: 26578293

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.

Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O

Nucleic Acids Res.. doi: 10.1093/nar/gkv1256

Publication date: November 17, 2015

PMID: 26582912

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S

Sci Adv. 1(10):e1500723. doi: 10.1126/sciadv.1500723

Publication date: November 13, 2015

PMID: 26702435

Structural Chemistry of Human RNA Methyltransferases.

Schapira M

ACS Chem. Biol.. doi: 10.1021/acschembio.5b00781

Publication date: November 13, 2015

PMID: 26566070

Emerging Target Families: Intractable Targets.

Knapp S

Handb Exp Pharmacol. doi: 10.1007/164_2015_28

Publication date: November 10, 2015

PMID: 26552403

Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Hing Che K, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan P, O'Mahony A, Velichko S, Muller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S

Cancer Res.. doi: 10.1158/0008-5472.CAN-15-0236

Publication date: November 9, 2015

PMID: 26552700

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.

Luan Y, Blazer LL, Hu H, Hajian T, Zhang J, Wu H, Houliston S, Arrowsmith CH, Vedadi M, Zheng YG

Org. Biomol. Chem.. doi: 10.1039/c5ob01794g

Publication date: November 6, 2015

PMID: 26541578

Structural basis for substrate recognition by the human N-terminal methyltransferase 1.

Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R, Min J

Genes Dev.. doi: 10.1101/gad.270611.115

Publication date: November 5, 2015

PMID: 26543161

Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.

Liu Y, Lau J, Li W, Tempel W, Li L, Dong A, Narula A, Qin S, Min J

Biochem. J.. doi: 10.1042/BJ20150830

Publication date: November 2, 2015

PMID: 26527736

Inflammation activation and resolution in human tendon disease.

Dakin SG, Martinez FO, Yapp C, Wells G, Oppermann U, Dean BJ, Smith RD, Wheway K, Watkins B, Roche L, Carr AJ

Sci Transl Med. 7(311):311ra173. doi: 10.1126/scitranslmed.aac4269

Publication date: October 28, 2015

PMID: 26511510

Comprehensive characterization of the Published Kinase Inhibitor Set.

Elkins JM, Fedele V, Szklarz M, Abdul Azeez KR, Salah E, Mikolajczyk J, Romanov S, Sepetov N, Huang XP, Roth BL, Al Haj Zen A, Fourches D, Muratov E, Tropsha A, Morris J, Teicher BA, Kunkel M, Polley E, Lackey KE, Atkinson FL, Overington JP, Bamborough P, Müller S, Price DJ, Willson TM, Drewry DH, Knapp S, Zuercher WJ

Nat. Biotechnol.. doi: 10.1038/nbt.3374

Publication date: October 26, 2015

PMID: 26501955

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.

Zhang Q, Fan L, Hou F, Dong A, Wang YX, Tong Y

Sci Rep. 5:15660. doi: 10.1038/srep15660

Publication date: October 23, 2015

PMID: 26489670

The ins and outs of selective kinase inhibitor development.

Müller S, Chaikuad A, Gray NS, Knapp S

Nat. Chem. Biol.. 11(11):818-21. doi: 10.1038/nchembio.1938

Publication date: October 20, 2015

PMID: 26485069

Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers.

Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ

Antimicrob. Agents Chemother.. doi: 10.1128/AAC.01335-15

Publication date: October 19, 2015

PMID: 26482303

Structural insights into the MMACHC-MMADHC protein complex involved in vitamin B12 trafficking.

Froese DS, Kopec J, Fitzpatrick F, Schuller M, McCorvie TJ, Chalk R, Plessl T, Fettelschoss V, Fowler B, Baumgartner MR, Yue WW

J. Biol. Chem.. doi: 10.1074/jbc.M115.683268

Publication date: October 19, 2015

PMID: 26483544

STRUCTURAL BIOLOGY. Chromatin complex, crystal clear.

Schapira M

Science. 350(6258):278-9. doi: 10.1126/science.aad5203

Publication date: October 16, 2015

PMID: 26472895

WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma.

Sun Y, Bell JL, Carter DR, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Huttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T

Cancer Res.. doi: 10.1158/0008-5472.CAN-15-0423

Publication date: October 15, 2015

PMID: 26471359

Targeting RIPK1,2,3 to combat inflammation.

Bullock AN, Degterev A

Oncotarget. doi: 10.18632/oncotarget.6106

Publication date: October 13, 2015

PMID: 26472031

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.

Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M, Guardiola P, Rousseaux S, Gérard M, Knapp S, Zhao Y, Khochbin S

J Mol Cell Biol. doi: 10.1093/jmcb/mjv060

Publication date: October 12, 2015

PMID: 26459632

Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step.

Huang R, Gorman KT, Vinci CR, Dobrovetsky E, Gräslund S, Kay BK

Int J Mol Sci. 16(10):23587-603. doi: 10.3390/ijms161023587

Publication date: October 6, 2015

PMID: 26437402

Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins.

Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, Huang H, Nadeem V, Sidhu SS, Greenblatt JF, Marcon E, Arrowsmith CH, Edwards AM, Gräslund S

PLoS ONE. 10(10):e0139695. doi: 10.1371/journal.pone.0139695

Publication date: October 5, 2015

PMID: 26437229

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

Cribbs A, Feldmann M, Oppermann U

Ther Adv Musculoskelet Dis. 7(5):206-19. doi: 10.1177/1759720X15598307

Publication date: October 2, 2015

PMID: 26425149

Structures and functions of mitochondrial ABC transporters.

Schaedler TA, Faust B, Shintre CA, Carpenter EP, Srinivasan V, van Veen HW, Balk J

Biochem. Soc. Trans.. 43(5):943-51. doi: 10.1042/BST20150118

Publication date: October 1, 2015

PMID: 26517908

Open access chemical probes for epigenetic targets.

Brown PJ, Müller S

Future Med Chem. doi: 10.4155/fmc.15.127

Publication date: September 23, 2015

PMID: 26397018

Crystal structure of human nuclear pore complex component NUP43.

Xu C, Li Z, He H, Wernimont A, Li Y, Loppnau P, Min J

FEBS Lett.. doi: 10.1016/j.febslet.2015.09.008

Publication date: September 19, 2015

PMID: 26391640

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.

Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL

Nature. 525(7568):206-11. doi: 10.1038/nature15251

Publication date: September 10, 2015

PMID: 26331536

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.

Darby RA, Unsworth A, Knapp S, Kerr ID, Callaghan R

Cancer Chemother. Pharmacol.. 76(4):853-64. doi: 10.1007/s00280-015-2858-9

Publication date: September 9, 2015

PMID: 26351135

Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass cases.

Gregson CL, Wheeler L, Hardcastle SA, Appleton LH, Addison KA, Brugmans M, Clark GR, Ward K, Paggiosi M, Stone M, Thomas J, Agarwal R, Poole K, McCloskey E, Fraser WD, Williams E, Bullock AN, Smith GD, Brown MA, Tobias JH, Duncan EL

J. Bone Miner. Res.. doi: 10.1002/jbmr.2706

Publication date: September 8, 2015

PMID: 26348019

Proteomic and biochemical studies of lysine malonylation suggests its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation.

Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC, Zhao Y

Mol. Cell Proteomics. doi: 10.1074/mcp.M115.048850

Publication date: August 28, 2015

PMID: 26320211

Structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins.

Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min J

J. Biol. Chem.. doi: 10.1074/jbc.M115.680389

Publication date: August 28, 2015

PMID: 26318451

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Tsoumpra MK, Muniz JR, Barnett BL, Kwaasi AA, Pilka ES, Kavanagh KL, Evdokimov A, Walter RL, Von Delft F, Ebetino FH, Oppermann U, Russell RG, Dunford JE

Bone. doi: 10.1016/j.bone.2015.08.020

Publication date: August 28, 2015

PMID: 26318908

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.

Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN

Chem. Biol.. doi: 10.1016/j.chembiol.2015.07.017

Publication date: August 26, 2015

PMID: 26320862

21(st) Century Cures Act: An Act of Cure or Diagnosis?

Brindley DA, Arshad Z, Luo D, Dopson S, Hollander G, Frost S, Bountra C, Smith JA

Rejuvenation Res. 18(4):295-8. doi: 10.1089/rej.2015.1757

Publication date: August 21, 2015

PMID: 26291241

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells.

Curry E, Green I, Chapman-Rothe N, Shamsaei E, Kandil S, Cherblanc FL, Payne L, Bell E, Ganesh T, Srimongkolpithak N, Caron J, Li F, Uren AG, Snyder JP, Vedadi M, Fuchter MJ, Brown R

Clin Epigenetics. 7(1):84. doi: 10.1186/s13148-015-0118-9

Publication date: August 21, 2015

PMID: 26300989

Differential recognition preferences of the three Src homology 3 (SH3) domains from the adaptor CD2-associated protein (CD2AP), and direct association with Ras and Rab interactor 3 (RIN3).

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM

J. Biol. Chem.. doi: 10.1074/jbc.M115.637207

Publication date: August 20, 2015

PMID: 26296892

A High Through-put Platform for Recombinant Antibodies to Folded Proteins.

Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J

Mol. Cell Proteomics. doi: 10.1074/mcp.O115.052209

Publication date: August 19, 2015

PMID: 26290498