ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation. Read more about ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. Read more about Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Read more about Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Photosensitization enables Pauson-Khand-type reactions with nitrenes. Read more about Photosensitization enables Pauson-Khand-type reactions with nitrenes.
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Read more about Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. Read more about Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Read more about Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
Kinetic characterization of human mRNA guanine-N7 methyltransferase. Read more about Kinetic characterization of human mRNA guanine-N7 methyltransferase.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. Read more about Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress. Read more about Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress.
