Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist. Read more about Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Anti-FHL1 autoantibodies in adult patients with myositis: a longitudinal follow-up analysis. Read more about Anti-FHL1 autoantibodies in adult patients with myositis: a longitudinal follow-up analysis.
The Pan-Canadian Chemical Library: A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening. Read more about The Pan-Canadian Chemical Library: A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening.
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Read more about Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. Read more about A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2. Read more about Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2.
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7. Read more about A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7.
Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence. Read more about Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence.
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Read more about More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication.
A data science roadmap for open science organizations engaged in early-stage drug discovery. Read more about A data science roadmap for open science organizations engaged in early-stage drug discovery.
