Matthieu Schapira, PhD is a Professor in the Department of Pharmacology and Toxicology, UofT, and is the head of computational chemistry, protein bioinformatics, and data management at the SGC-Toronto. He leads the CACHE initiative for benchmarking computational ‘hit finding’. Dr. Schapira is a recognized authority in the structural chemistry of drug target classes such as chromatin regulators, ubiquitylation pathways and WDR proteins, and has created popular online informatics resources for these targets such as Chromohub, Ubihub and ChemBioPort. He is interested in novel strategies to expand and ML tools to exploit the accessible chemistry space. His trainees have gone on to become important innovators in AI-driven drug discovery at Toronto-born biotechs such as Atomwise and Cyclica.
Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HÜ, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, De Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH
Nat Commun. 2019-1-3 . 10(1):19 .doi: 10.1038/s41467-018-07905-4
PMID: 30604761Liu L, Damerell DR, Koukouflis L, Tong Y, Marsden BD, Schapira M
Bioinformatics. 2019-1-2 . .doi: 10.1093/bioinformatics/bty1067
PMID: 30601939Ferreira de Freitas R, Harding RJ, Franzoni I, Ravichandran M, Mann MK, Ouyang H, Lautens M, Santhakumar V, Arrowsmith CH, Schapira M
J. Med. Chem.. 2018-5-9 . .doi: 10.1021/acs.jmedchem.8b00258
PMID: 29741882Nakayama K, Szewczyk MM, Dela Sena C, Wu H, Dong A, Zeng H, Li F, de Freitas RF, Eram MS, Schapira M, Baba Y, Kunitomo M, Cary DR, Tawada M, Ohashi A, Imaeda Y, Saikatendu KS, Grimshaw CE, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, Kiba A, Tomita D, Brown PJ
Oncotarget. 2018-4-6 . 9(26):18480-18493 .doi: 10.18632/oncotarget.24883
PMID: 29719619Kaniskan HÜ, Eram MS, Zhao K, Szewczyk MM, Yang X, Schmidt K, Luo X, Xiao S, Dai M, He F, Zang I, Lin Y, Li F, Dobrovetsky E, Smil D, Min SJ, Lin-Jones J, Schapira M, Atadja P, Li E, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Liu F, Yu Z, Vedadi M, Jin J
J. Med. Chem.. 2017-12-15 . .doi: 10.1021/acs.jmedchem.7b01674
PMID: 29244490Schapira M, Tyers M, Torrent M, Arrowsmith CH
Nat Rev Drug Discov. 2017-10-13 . .doi: 10.1038/nrd.2017.179
PMID: 29026209Harding RJ, Ferreira de Freitas R, Collins PM, Franzoni I, Ravichandran M, Ouyang H, Juarez-Ornelas KA, Lautens M, Schapira M, von Delft F, Santhakumar V, Arrowsmith CH
J. Med. Chem.. 2017-10-11 . .doi: 10.1021/acs.jmedchem.7b00933
PMID: 29019676Ferreira de Freitas R, Schapira M
Medchemcomm. 2017-10-1 . 8(10):1970-1981 .doi: 10.1039/c7md00381a
PMID: 29308120Song R, Wang ZD, Schapira M
J. Proteome Res.. 2017-9-28 . .doi: 10.1021/acs.jproteome.7b00451
PMID: 28956604Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P
Cell Rep. 2016-12-6 . 17(10):2724-2737 .doi: 10.1016/j.celrep.2016.11.014
PMID: 27926874