David Drewry is a renowned leader in the medicinal chemistry of protein kinases and is one of the principal architects of the research strategy at the SGC-UNC to build an open and collaborative research network to promote target discovery. He previously enjoyed more than 24 years as a medicinal chemist with GlaxoSmithKline and legacy companies, where he led teams working across the preclinical spectrum of drug discovery. His research interests include the art and science of medicinal chemistry, kinase inhibitor design, utilization of annotated sets of kinase inhibitors to build understanding of signaling networks and precompetitive chemical biology to facilitate target identification. After earning a Bachelor’s of Science degree, cum laude, in chemistry from Yale University, Drewry earned his doctorate at the University of California, Berkeley in the laboratory of Paul Bartlett, working on the design, synthesis and mechanistic studies of zinc protease inhibitors. Drewry is currently the head of chemistry at Meryx Pharmaceuticals, a biotech startup focused on small-molecule inhibitors of Mer kinase that was a spinoff from the UNC Eshelman School of Pharmacy. Drewry enjoys running, reading and relaxing with his family at local restaurants, the movie theater or in the kitchen playing board games.
Matossian MD, Wells CI, Zuercher WJ, Collins-Burow BM, Drewry DH, Burow ME
Curr Med Chem. 2021-3-21 . .doi: 10.2174/0929867328666210322101749
PMID: 33749548Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD
Cell Chem Biol. 2021-1-11 . .doi: 10.1016/j.chembiol.2020.12.013
PMID: 33484635Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM, Drewry DH
Int J Mol Sci. 2021-1-8 . 22(2): .doi: 10.3390/ijms22020566
PMID: 33429995Picado A, Chaikuad A, Wells CI, Shrestha S, Zuercher WJ, Pickett JE, Kwarcinski FE, Sinha P, de Silva CS, Zutshi R, Liu S, Kannan N, Knapp S, Drewry DH, Willson TM
J Med Chem. 2020-11-20 . .doi: 10.1021/acs.jmedchem.0c01174
PMID: 33215924Schröder M, Filippakopoulos P, Schwalm MP, Ferrer CA, Drewry DH, Knapp S, Chaikuad A
Int J Mol Sci. 2020-10-26 . 21(21): .doi: 10.3390/ijms21217953
PMID: 33114754Tamir TY, Drewry DH, Wells C, Major MB, Axtman AD
Sci Rep. 2020-9-28 . 10(1):15826 .doi: 10.1038/s41598-020-72869-9
PMID: 32985588O'Byrne SN, Eduful BJ, Willson TM, Drewry DH
Tetrahedron Lett. 2020-9-17 . 61(38): .doi: 10.1016/j.tetlet.2020.152353
PMID: 33012852Matossian MD, Burks HE, Elliott S, Hoang VT, Zuercher WJ, Wells C, Drewry DH, Kapadia N, Chang T, Yan T, Windsor GO, Nguyen K, Fang F, Nephew KP, Buechlein A, Rusch DB, Sabol RA, Ucar DA, Zabaleta J, Miele L, Bunnell BA, Collins-Burow BM, Burow ME
Anticancer Drugs. 2020-8-17 . 31(8):759-775 .doi: 10.1097/CAD.0000000000000962
PMID: 32796402Anderson E, Havener TM, Zorn KM, Foil DH, Lane TR, Capuzzi SJ, Morris D, Hickey AJ, Drewry DH, Ekins S
Sci Rep. 2020-7-31 . 10(1):12982 .doi: 10.1038/s41598-020-70026-w
PMID: 32737414Herneisen AL, Sidik SM, Markus BM, Drewry DH, Zuercher WJ, Lourido S
ACS Chem. Biol.. 2020-6-29 . .doi: 10.1021/acschembio.0c00369
PMID: 32597628