David Drewry is a renowned leader in the medicinal chemistry of protein kinases and is one of the principal architects of the research strategy at the SGC-UNC to build an open and collaborative research network to promote target discovery. He previously enjoyed more than 24 years as a medicinal chemist with GlaxoSmithKline and legacy companies, where he led teams working across the preclinical spectrum of drug discovery. His research interests include the art and science of medicinal chemistry, kinase inhibitor design, utilization of annotated sets of kinase inhibitors to build understanding of signaling networks and precompetitive chemical biology to facilitate target identification. After earning a Bachelor’s of Science degree, cum laude, in chemistry from Yale University, Drewry earned his doctorate at the University of California, Berkeley in the laboratory of Paul Bartlett, working on the design, synthesis and mechanistic studies of zinc protease inhibitors. Drewry is currently the head of chemistry at Meryx Pharmaceuticals, a biotech startup focused on small-molecule inhibitors of Mer kinase that was a spinoff from the UNC Eshelman School of Pharmacy. Drewry enjoys running, reading and relaxing with his family at local restaurants, the movie theater or in the kitchen playing board games.
Wells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang BB, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB
Nat Commun. 2020-6-2 . 11(1):2743 .doi: 10.1038/s41467-020-16559-0
PMID: 32488087Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD
ACS Chem Neurosci. 2020-5-28 . .doi: 10.1021/acschemneuro.0c00176
PMID: 32464049Howarth A, Schröder M, Montenegro RC, Drewry DH, Heba S, Millar V, Müller S, Ebner DV
SLAS Discov. 2020-5-27 . 2472555220923979 .doi: 10.1177/2472555220923979
PMID: 32458721Ketley A, Wojciechowska M, Ghidelli-Disse S, Bamborough P, Ghosh TK, Morato ML, Sedehizadeh S, Malik NA, Tang Z, Powalowska P, Tanner M, Billeter-Clark R, Trueman RC, Geiszler PC, Agostini A, Othman O, Bösche M, Bantscheff M, Rüdiger M, Mossakowska DE, Drewry DH, Zuercher WJ, Thornton CA, Drewes G, Uings I, Hayes CJ, Brook JD
Sci Transl Med. 2020-4-29 . 12(541): .doi: 10.1126/scitranslmed.aaz2415
PMID: 32350131Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman AD
ACS Med Chem Lett. 2020-3-12 . 11(3):340-345 .doi: 10.1021/acsmedchemlett.9b00399
PMID: 32184967O'Byrne SN, Scott JW, Pilotte JR, Santiago ADS, Langendorf CG, Oakhill JS, Eduful BJ, Couñago RM, Wells CI, Zuercher WJ, Willson TM, Drewry DH
Molecules. 2020-1-13 . 25(2): .doi: 10.3390/molecules25020325
PMID: 31941153Profeta GS, Dos Reis CV, Santiago ADS, Godoi PHC, Fala AM, Wells CI, Sartori R, Salmazo APT, Ramos PZ, Massirer KB, Elkins JM, Drewry DH, Gileadi O, Couñago RM
Sci Rep. 2019-11-11 . 9(1):16452 .doi: 10.1038/s41598-019-52795-1
PMID: 31712618Burdova K, Yang H, Faedda R, Hume S, Chauhan J, Ebner D, Kessler BM, Vendrell I, Drewry DH, Wells CI, Hatch SB, Dianov GL, Buffa FM, D'Angiolella V
EMBO J.. 2019-8-19 . e101443 .doi: 10.15252/embj.2018101443
PMID: 31424118Axtman A, Drewry D, Wells C
Nat Rev Drug Discov. 2019-7-4 . 18(7):489 .doi: 10.1038/d41573-019-00076-x
PMID: 31267068Drewry DH, Wells CI, Zuercher WJ, Willson TM
SLAS Discov. 2019-4-29 . 2472555219838210 .doi: 10.1177/2472555219838210
PMID: 31034310