Publications | Structural Genomics Consortium

Andersson CD, Karlberg T, Ekblad T, Lindgren AE, Thorsell AG, Spjut S, Uciechowska U, Niemiec MS, Wittung-Stafshede P, Weigelt J, Elofsson M, Schüler H, Linusson A

J. Med. Chem.. 55(17):7706-18. doi: 10.1021/jm300746d

Publication date: September 13, 2012

PMID: 22823910

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.

Vidler LR, Brown N, Knapp S, Hoelder S

J. Med. Chem.. 55(17):7346-59. doi: 10.1021/jm300346w

Publication date: September 13, 2012

PMID: 22788793

Structural determination of the phosphorylation domain of the ryanodine receptor.

Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, MacLennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO

FEBS J.. 279(20):3952-64. doi: 10.1111/j.1742-4658.2012.08755.x

Publication date: September 11, 2012

PMID: 22913516

Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid.

Eixelsberger T, Sykora S, Egger S, Brunsteiner M, Kavanagh KL, Oppermann U, Brecker L, Nidetzky B

J. Biol. Chem.. 287(37):31349-58. doi: 10.1074/jbc.M112.386706

Publication date: September 7, 2012

PMID: 22810237

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED

J. Mol. Biol.. 422(1):3-17. doi: 10.1016/j.jmb.2012.04.031

Publication date: September 7, 2012

PMID: 22575888

C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells.

Chand D, Song L, deLannoy L, Barsyte-Lovejoy D, Ackloo S, Boutros PC, Evans K, Belsham DD, Lovejoy DA

Neuroscience. 219:255-70. doi: 10.1016/j.neuroscience.2012.05.069

Publication date: September 6, 2012

PMID: 22698694

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

Prudent R, Vassal-Stermann E, Nguyen CH, Pillet C, Martinez A, Prunier C, Barette C, Soleilhac E, Filhol O, Beghin A, Valdameri G, Honoré S, Aci-Sèche S, Grierson D, Antonipillai J, Li R, Di Pietro A, Dumontet C, Braguer D, Florent JC, Knapp S, Bernard O, Lafanechère L

Cancer Res.. 72(17):4429-39. doi: 10.1158/0008-5472.CAN-11-3342

Publication date: September 1, 2012

PMID: 22761334

The corky root rot pathogen Pyrenochaeta lycopersici secretes a proteinaceous inducer of cell death affecting host plants differentially.

Clergeot PH, Schuler H, Mørtz E, Brus M, Vintila S, Ekengren S

Phytopathology. 102(9):878-91. doi: 10.1094/PHYTO-01-12-0004

Publication date: September 1, 2012

PMID: 22708726

Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.

Bezerra GA, Dobrovetsky E, Dong A, Seitova A, Crombett L, Shewchuk LM, Hassell AM, Sweitzer SM, Sweitzer TD, McDevitt PJ, Johanson KO, Kennedy-Wilson KM, Cossar D, Bochkarev A, Gruber K, Dhe-Paganon S

PLoS ONE. 7(8):e43019. doi: 10.1371/journal.pone.0043019

Publication date: August 29, 2012

PMID: 22952628

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG

Nat. Chem. Biol.. 8(10):839-47. doi: 10.1038/nchembio.1060

Publication date: August 26, 2012

PMID: 22922757

Fragment screening of cyclin G-associated kinase by weak affinity chromatography.

Meiby E, Knapp S, Elkins JM, Ohlson S

Anal Bioanal Chem. 404(8):2417-25. doi: 10.1007/s00216-012-6335-6

Publication date: August 24, 2012

PMID: 22918538

Small-molecule inhibition of BRDT for male contraception.

Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE

Cell. 150(4):673-84. doi: 10.1016/j.cell.2012.06.045

Publication date: August 17, 2012

PMID: 22901802

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM

Nature. 488(7411):404-8. doi: 10.1038/nature11262

Publication date: August 16, 2012

PMID: 22842901

ChromoHub: a data hub for navigators of chromatin-mediated signalling.

Liu L, Zhen XT, Denton E, Marsden BD, Schapira M

Bioinformatics. 28(16):2205-6. doi: 10.1093/bioinformatics/bts340

Publication date: August 15, 2012

PMID: 22718786

The bromodomain interaction module.

Filippakopoulos P, Knapp S

FEBS Lett.. 586(17):2692-704. doi: 10.1016/j.febslet.2012.04.045

Publication date: August 14, 2012

PMID: 22710155

An allosteric inhibitor of protein arginine methyltransferase 3.

Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, Zeng H, Loppnau P, Poda G, Griffin C, Aman A, Brown PJ, Jin J, Al-Awar R, Arrowsmith CH, Schapira M, Vedadi M

Structure. 20(8):1425-35. doi: 10.1016/j.str.2012.06.001

Publication date: August 8, 2012

PMID: 22795084

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.

Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ

J. Biol. Chem.. 287(31):26254-67. doi: 10.1074/jbc.M112.367243

Publication date: July 27, 2012

PMID: 22692201

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A

J. Med. Chem.. 55(14):6639-43. doi: 10.1021/jm300677j

Publication date: July 26, 2012

PMID: 22724510

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.

Rydzik AM, Leung IK, Kochan GT, Thalhammer A, Oppermann U, Claridge TD, Schofield CJ

Chembiochem. 13(11):1559-63. doi: 10.1002/cbic.201200256

Publication date: July 23, 2012

PMID: 22730246

Crystal structure of human ADP-ribose transferase ARTD15/PARP16 reveals a novel putative regulatory domain.

Karlberg T, Thorsell AG, Kallas Å, Schüler H

J. Biol. Chem.. 287(29):24077-81. doi: 10.1074/jbc.M112.379289

Publication date: July 13, 2012

PMID: 22661712

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase.

Bandini G, Mariño K, Güther ML, Wernimont AK, Kuettel S, Qiu W, Afzal S, Kelner A, Hui R, Ferguson MA

Mol. Microbiol.. 85(3):513-34. doi: 10.1111/j.1365-2958.2012.08124.x

Publication date: July 12, 2012

PMID: 22676716

Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN

J. Biol. Chem.. 287(28):23900-10. doi: 10.1074/jbc.M112.359653

Publication date: July 6, 2012

PMID: 22589545

WITHDRAWN: Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S

Biochem. Biophys. Res. Commun.. doi: 10.1016/j.bbrc.2012.06.130

Publication date: July 4, 2012

PMID: 22771810

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH

J. Biol. Chem.. 287(27):22483-96. doi: 10.1074/jbc.M112.352773

Publication date: June 29, 2012

PMID: 22493426

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.

Froese DS, Krojer T, Wu X, Shrestha R, Kiyani W, von Delft F, Gravel RA, Oppermann U, Yue WW

Biochemistry. 51(25):5083-90. doi: 10.1021/bi300150y

Publication date: June 26, 2012

PMID: 22642810

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW

BMC Struct. Biol.. 12:14. doi: 10.1186/1472-6807-12-14

Publication date: June 21, 2012

PMID: 22720794

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.

Keates T, Cooper CD, Savitsky P, Allerston CK, Phillips C, Hammarström M, Daga N, Berridge G, Mahajan P, Burgess-Brown NA, Müller S, Gräslund S, Gileadi O

N Biotechnol. 29(5):515-25. doi: 10.1016/j.nbt.2011.10.007

Publication date: June 15, 2012

PMID: 22027370

The corky root rot pathogen Pyrenochaeta lycopersici secretes a proteinaceous inducer of cell death affecting host plants differentially.

Clergeot PH, Schuler H, Mørtz E, Brus M, Vintila S, Ekengren S

Phytopathology.

Publication date: June 6, 2012

PMID: 22671025

Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1.

Wu H, Moshkina N, Min J, Zeng H, Joshua J, Zhou MM, Plotnikov AN

Proc. Natl. Acad. Sci. U.S.A.. 109(23):8925-30. doi: 10.1073/pnas.1114117109

Publication date: June 5, 2012

PMID: 22615379

3-methylcrotonyl-CoA carboxylase deficiency: clinical, biochemical, enzymatic and molecular studies in 88 individuals.

Grünert SC, Stucki M, Morscher RJ, Suormala T, Bürer C, Burda P, Christensen E, Ficicioglu C, Herwig J, Kölker S, Möslinger D, Pasquini E, Santer R, Schwab KO, Wilcken B, Fowler B, Yue WW, Baumgartner MR

Orphanet J Rare Dis. 7:31. doi: 10.1186/1750-1172-7-31

Publication date: May 29, 2012

PMID: 22642865

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T, Yang XJ, Min J

Sci Signal. 5(226):ra39. doi: 10.1126/scisignal.2002979

Publication date: May 29, 2012

PMID: 22649097