Publications | Structural Genomics Consortium

Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.

Singh BK, Sattler JM, Chatterjee M, Huttu J, Schüler H, Kursula I

J. Biol. Chem.. 286(32):28256-64. doi: 10.1074/jbc.M111.211730

Publication date: August 12, 2011

PMID: 21832095

Characterization of 14-3-3 proteins from Cryptosporidium parvum.

Brokx SJ, Wernimont AK, Dong A, Wasney GA, Lin YH, Lew J, Vedadi M, Lee WH, Hui R

PLoS ONE. 6(8):e14827. doi: 10.1371/journal.pone.0014827

Publication date: August 11, 2011

PMID: 21853016

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS

Chem. Biol.. 18(7):868-79. doi: 10.1016/j.chembiol.2011.05.010

Publication date: July 29, 2011

PMID: 21802008

Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs).

Wang H, Hota PK, Tong Y, Li B, Shen L, Nedyalkova L, Borthakur S, Kim S, Tempel W, Buck M, Park HW

J. Biol. Chem.. 286(29):26093-106. doi: 10.1074/jbc.M110.197053

Publication date: July 22, 2011

PMID: 21610070

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.

Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J

EMBO J.. 30(14):2829-42. doi: 10.1038/emboj.2011.193

Publication date: July 20, 2011

PMID: 21685874

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J

Nat. Chem. Biol.. 7(8):566-74. doi: 10.1038/nchembio.599

Publication date: July 10, 2011

PMID: 21743462

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Opperman U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Moutsianis L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P, Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Díaz-Peña R, López-Vázquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Wordsworth BP, Brown MA, Donnelly P

Nat. Genet.. 43(8):761-7. doi: 10.1038/ng.873

Publication date: July 10, 2011

PMID: 21743469

Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.

Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chédin F, Arrowsmith CH, Dhe-Paganon S

J. Biol. Chem.. 286(27):24300-11. doi: 10.1074/jbc.M111.234104

Publication date: July 8, 2011

PMID: 21489993

Structure and mechanism of human UDP-glucose 6-dehydrogenase.

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B

J. Biol. Chem.. 286(27):23877-87. doi: 10.1074/jbc.M111.234682

Publication date: July 8, 2011

PMID: 21502315

PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.

Zhang Z, Jones A, Sun CW, Li C, Chang CW, Joo HY, Dai Q, Mysliwiec MR, Wu LC, Guo Y, Yang W, Liu K, Pawlik KM, Erdjument-Bromage H, Tempst P, Lee Y, Min J, Townes TM, Wang H

Stem Cells. 29(2):229-40. doi: 10.1002/stem.578

Publication date: July 7, 2011

PMID: 21732481

Composition, recruitment and regulation of the PRC2 complex.

Nayak V, Xu C, Min J

Nucleus. 2(4):277-82. doi: 10.4161/nucl.2.4.16266

Publication date: July 1, 2011

PMID: 21941108

Comparative structural analysis of lipid binding START domains.

Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schüler H, Lehtiö L

PLoS ONE. 6(6):e19521. doi: 10.1371/journal.pone.0019521

Publication date: June 30, 2011

PMID: 21738568

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F

Cell. 145(7):1075-87. doi: 10.1016/j.cell.2011.05.039

Publication date: June 24, 2011

PMID: 21683433

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP

J. Med. Chem.. 54(12):4172-86. doi: 10.1021/jm200274d

Publication date: June 23, 2011

PMID: 21615147

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.

Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, Schreiber SL, Wang X

J. Am. Chem. Soc.. 133(24):9451-6. doi: 10.1021/ja201597b

Publication date: June 22, 2011

PMID: 21585201

Leveraging crowdsourcing to facilitate the discovery of new medicines.

Norman TC, Bountra C, Edwards AM, Yamamoto KR, Friend SH

Sci Transl Med. 3(88):88mr1. doi: 10.1126/scitranslmed.3002678

Publication date: June 22, 2011

PMID: 21697527

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW

Proc. Natl. Acad. Sci. U.S.A.. 108(25):10139-43. doi: 10.1073/pnas.1019441108

Publication date: June 21, 2011

PMID: 21636783

Structural and histone binding ability characterizations of human PWWP domains.

Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J

PLoS ONE. 6(6):e18919. doi: 10.1371/journal.pone.0018919

Publication date: June 20, 2011

PMID: 21720545

Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.

Singh BK, Sattler JM, Chatterjee M, Huttu J, Schuler H, Kursula I

J. Biol. Chem..

Publication date: June 15, 2011

PMID: 21676876

Characterization of a new phosphatase from Plasmodium.

Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC

Mol. Biochem. Parasitol.. 179(2):69-79. doi: 10.1016/j.molbiopara.2011.06.001

Publication date: June 13, 2011

PMID: 21689687

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.

Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA

Biochem. Biophys. Res. Commun.. 408(4):553-8. doi: 10.1016/j.bbrc.2011.04.059

Publication date: May 20, 2011

PMID: 21530488

A roadmap to generate renewable protein binders to the human proteome.

Colwill K, Gräslund S

Nat. Methods. 8(7):551-8. doi: 10.1038/nmeth.1607

Publication date: May 15, 2011

PMID: 21572409

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M, von Delft F, Kavanagh KL, Brown MA, Bowness P, Wordsworth P, Kessler BM, Oppermann U

Proc. Natl. Acad. Sci. U.S.A.. 108(19):7745-50. doi: 10.1073/pnas.1101262108

Publication date: May 10, 2011

PMID: 21508329

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.

Mariño K, Güther ML, Wernimont AK, Qiu W, Hui R, Ferguson MA

Eukaryotic Cell. 10(7):985-97. doi: 10.1128/EC.05025-11

Publication date: April 29, 2011

PMID: 21531872

The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.

Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C

J. Biol. Chem.. 286(17):15344-51. doi: 10.1074/jbc.M110.209882

Publication date: April 29, 2011

PMID: 21389349

Structure and biochemical functions of SIRT6.

Pan PW, Feldman JL, Devries MK, Dong A, Edwards AM, Denu JM

J. Biol. Chem.. 286(16):14575-87. doi: 10.1074/jbc.M111.218990

Publication date: April 22, 2011

PMID: 21362626

Interactive JIMD articles using the iSee concept: turning a new page on structural biology data.

Lee WH, Yue WW, Raush E, Totrov M, Abagyan R, Oppermann U, Marsden BD

J. Inherit. Metab. Dis.. 34(3):565-7. doi: 10.1007/s10545-011-9334-4

Publication date: April 21, 2011

PMID: 21509537

Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kräling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen LO, Meggers E

J. Am. Chem. Soc.. 133(15):5976-86. doi: 10.1021/ja1112996

Publication date: April 20, 2011

PMID: 21446733

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.

Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I

J. Biol. Chem.. 286(15):13261-71. doi: 10.1074/jbc.M110.206771

Publication date: April 15, 2011

PMID: 21257746

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.

Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady RL, Oppermann U, Frayne J, Yue WW

Biochem. J.. 435(2):401-9. doi: 10.1042/BJ20101442

Publication date: April 15, 2011

PMID: 21269272

Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

Salah E, Ugochukwu E, Barr AJ, von Delft F, Knapp S, Elkins JM

J. Med. Chem.. 54(7):2359-67. doi: 10.1021/jm101506n

Publication date: April 14, 2011

PMID: 21417343

Small-molecule ligands of methyl-lysine binding proteins.

Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV

J. Med. Chem.. 54(7):2504-11. doi: 10.1021/jm200045v

Publication date: April 14, 2011

PMID: 21417280

Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects.

Krojer T, von Delft F

J Synchrotron Radiat. 18(Pt 3):387-97. doi: 10.1107/S0909049511008235

Publication date: April 9, 2011

PMID: 21525647

The relationship between the chemistry and biological activity of the bisphosphonates.

Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG

Bone. 49(1):20-33. doi: 10.1016/j.bone.2011.03.774

Publication date: April 9, 2011

PMID: 21497677

Structure and function of WD40 domain proteins.

Xu C, Min J

Protein Cell. 2(3):202-14. doi: 10.1007/s13238-011-1018-1

Publication date: April 6, 2011

PMID: 21468892

The precompetitive space: time to move the yardsticks.

Norman T, Edwards A, Bountra C, Friend S

Sci Transl Med. 3(76):76cm10. doi: 10.1126/scitranslmed.3002399

Publication date: March 30, 2011

PMID: 21451121

Structural basis of fumarate hydratase deficiency.

Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U

J. Inherit. Metab. Dis.. 34(3):671-6. doi: 10.1007/s10545-011-9294-8

Publication date: March 29, 2011

PMID: 21445611

Structural chemistry of the histone methyltransferases cofactor binding site.

Campagna-Slater V, Mok MW, Nguyen KT, Feher M, Najmanovich R, Schapira M

J Chem Inf Model. 51(3):612-23. doi: 10.1021/ci100479z

Publication date: March 28, 2011

PMID: 21366357

The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.

Xu C, Bian C, Lam R, Dong A, Min J

Nat Commun. 2:227. doi: 10.1038/ncomms1237

Publication date: March 17, 2011

PMID: 21407193

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins.

Berridge G, Chalk R, D'Avanzo N, Dong L, Doyle D, Kim JI, Xia X, Burgess-Brown N, Deriso A, Carpenter EP, Gileadi O

Anal. Biochem.. 410(2):272-80. doi: 10.1016/j.ab.2010.11.008

Publication date: March 15, 2011

PMID: 21093405

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.

Liao JC, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, Xiao T, Tempel W, Zuo X, Wang YX, Chirgadze NY, Arrowsmith CH

Structure. 19(3):418-29. doi: 10.1016/j.str.2010.12.015

Publication date: March 9, 2011

PMID: 21397192

A novel ACVR1 mutation in the glycine/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date.

Gregson CL, Hollingworth P, Williams M, Petrie KA, Bullock AN, Brown MA, Tobias JH, Triffitt JT

Bone. 48(3):654-8. doi: 10.1016/j.bone.2010.10.164

Publication date: March 1, 2011

PMID: 21044902

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA

Blood. 117(8):2451-9. doi: 10.1182/blood-2010-11-321208

Publication date: February 24, 2011

PMID: 21190999

High-throughput structural biology of metabolic enzymes and its impact on human diseases.

Yue WW, Oppermann U

J. Inherit. Metab. Dis.. 34(3):575-81. doi: 10.1007/s10545-011-9296-6

Publication date: February 22, 2011

PMID: 21340633

DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.

Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sentürk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, Dötsch V

Cell. 144(4):566-76. doi: 10.1016/j.cell.2011.01.013

Publication date: February 18, 2011

PMID: 21335238