Publications

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2009

Vital role for the Plasmodium actin capping protein (CP) beta-subunit in motility of malaria sporozoites.

Ganter M, Schüler H, Matuschewski K

Mol. Microbiol.. 74(6):1356-67. doi: 10.1111/j.1365-2958.2009.06828.x

Publication date: December 1, 2009

PMID: 19682250

SH2 domains: modulators of nonreceptor tyrosine kinase activity.

Filippakopoulos P, Müller S, Knapp S

Curr. Opin. Struct. Biol.. 19(6):643-9. doi: 10.1016/j.sbi.2009.10.001

Publication date: November 18, 2009

PMID: 19926274

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.

Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, Park HW, Schapira M, Vedadi M

Biochem. J.. 424(1):15-26. doi: 10.1042/BJ20090723

Publication date: November 15, 2009

PMID: 19702579

Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.

Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH

Biochemistry. 48(44):10542-8. doi: 10.1021/bi901131u

Publication date: November 10, 2009

PMID: 19791798

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.

Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A

Nucleic Acids Res.. 38(2):e11. doi: 10.1093/nar/gkp899

Publication date: November 6, 2009

PMID: 19897549

Investigating the genetic association between ERAP1 and ankylosing spondylitis.

Harvey D, Pointon JJ, Evans DM, Karaderi T, Farrar C, Appleton LH, Sturrock RD, Stone MA, Oppermann U, Brown MA, Wordsworth BP

Hum. Mol. Genet.. 18(21):4204-12. doi: 10.1093/hmg/ddp371

Publication date: November 1, 2009

PMID: 19692350

Insights into protein kinase regulation and inhibition by large scale structural comparison.

Eswaran J, Knapp S

Biochim. Biophys. Acta. 1804(3):429-32. doi: 10.1016/j.bbapap.2009.10.013

Publication date: October 22, 2009

PMID: 19854302

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.

Akué-Gédu R, Rossignol E, Azzaro S, Knapp S, Filippakopoulos P, Bullock AN, Bain J, Cohen P, Prudhomme M, Anizon F, Moreau P

J. Med. Chem.. 52(20):6369-81. doi: 10.1021/jm901018f

Publication date: October 22, 2009

PMID: 19788246

A new method for publishing three-dimensional content.

Raush E, Totrov M, Marsden BD, Abagyan R

PLoS ONE. 4(10):e7394. doi: 10.1371/journal.pone.0007394

Publication date: October 20, 2009

PMID: 19841676

Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7.

Karlberg T, van den Berg S, Hammarström M, Sagemark J, Johansson I, Holmberg-Schiavone L, Schüler H

PLoS ONE. 4(10):e6975. doi: 10.1371/journal.pone.0006975

Publication date: October 20, 2009

PMID: 19841671

Crystal structure of the N-acetylmannosamine kinase domain of GNE.

Tong Y, Tempel W, Nedyalkova L, Mackenzie F, Park HW

PLoS ONE. 4(10):e7165. doi: 10.1371/journal.pone.0007165

Publication date: October 20, 2009

PMID: 19841673

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

Bullock AN, Russo S, Amos A, Pagano N, Bregman H, Debreczeni JE, Lee WH, von Delft F, Meggers E, Knapp S

PLoS ONE. 4(10):e7112. doi: 10.1371/journal.pone.0007112

Publication date: October 20, 2009

PMID: 19841674

SGC--structural biology and human health: a new approach to publishing structural biology results.

Lee WH, Atienza-Herrero J, Abagyan R, Marsden BD

PLoS ONE. 4(10):e7675. doi: 10.1371/journal.pone.0007675

Publication date: October 20, 2009

PMID: 19847312

Structural basis for substrate specificity in human monomeric carbonyl reductases.

Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U

PLoS ONE. 4(10):e7113. doi: 10.1371/journal.pone.0007113

Publication date: October 20, 2009

PMID: 19841672

Structural studies of a four-MBT repeat protein MBTD1.

Eryilmaz J, Pan P, Amaya MF, Allali-Hassani A, Dong A, Adams-Cioaba MA, Mackenzie F, Vedadi M, Min J

PLoS ONE. 4(10):e7274. doi: 10.1371/journal.pone.0007274

Publication date: October 20, 2009

PMID: 19841675

Conformational stability and activity of p73 require a second helix in the tetramerization domain.

Coutandin D, Löhr F, Niesen FH, Ikeya T, Weber TA, Schäfer B, Zielonka EM, Bullock AN, Yang A, Güntert P, Knapp S, McKeon F, Ou HD, Dötsch V

Cell Death Differ.. 16(12):1582-9. doi: 10.1038/cdd.2009.139

Publication date: September 18, 2009

PMID: 19763140

Prepublication data sharing.

Birney E, Hudson TJ, Green ED, Gunter C, Eddy S, Rogers J, Harris JR, Ehrlich SD, Apweiler R, Austin CP, Berglund L, Bobrow M, Bountra C, Brookes AJ, Cambon-Thomsen A, Carter NP, Chisholm RL, Contreras JL, Cooke RM, Crosby WL, Dewar K, Durbin R, Dyke SO, Ecker JR, El Emam K, Feuk L, Gabriel SB, Gallacher J, Gelbart WM, Granell A, Guarner F, Hubbard T, Jackson SA, Jennings JL, Joly Y, Jones SM, Kaye J, Kennedy KL, Knoppers BM, Kyrpides NC, Lowrance WW, Luo J, MacKay JJ, Martín-Rivera L, McCombie WR, McPherson JD, Miller L, Miller W, Moerman D, Mooser V, Morton CC, Ostell JM, Ouellette BF, Parkhill J, Raina PS, Rawlings C, Scherer SE, Scherer SW, Schofield PN, Sensen CW, Stodden VC, Sussman MR, Tanaka T, Thornton J, Tsunoda T, Valle D, Vuorio EI, Walker NM, Wallace S, Weinstock G, Whitman WB, Worley KC, Wu C, Wu J, Yu J

Nature. 461(7261):168-70. doi: 10.1038/461168a

Publication date: September 10, 2009

PMID: 19741685

Propionate analogues of zearalenone bind to Hsp90.

Ugele M, Sasse F, Knapp S, Fedorov O, Zubriene A, Matulis D, Maier ME

Chembiochem. 10(13):2203-12. doi: 10.1002/cbic.200900109

Publication date: September 4, 2009

PMID: 19637143

The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery.

Weigelt J

EMBO Rep.. 10(9):941-5. doi: 10.1038/embor.2009.193

Publication date: September 2, 2009

PMID: 19721463

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S, Pogacic V, Villa A, Ehret S, Berridge G, Spoo A, Dierks C, Biondi A, Knapp S, Duyster J, Schwaller J

J. Exp. Med.. 206(9):1957-70. doi: 10.1084/jem.20082074

Publication date: August 31, 2009

PMID: 19687226

Evaluation of virtual screening as a tool for chemical genetic applications.

Campagna-Slater V, Schapira M

J Chem Inf Model. 49(9):2082-91. doi: 10.1021/ci900219u

Publication date: August 26, 2009

PMID: 19702241

Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide.

Alag R, Bharatham N, Dong A, Hills T, Harikishore A, Widjaja AA, Shochat SG, Hui R, Yoon HS

Protein Sci.. 18(10):2115-24. doi: 10.1002/pro.226

Publication date: August 20, 2009

PMID: 19691130

Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases.

Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S

FEBS J.. 276(16):4395-404. doi: 10.1111/j.1742-4658.2009.07147.x

Publication date: August 15, 2009

PMID: 19678838

Out of the box binding determines specificity of SH2 domain interaction.

Müller S, Knapp S

Structure. 17(8):1040-1. doi: 10.1016/j.str.2009.07.002

Publication date: August 12, 2009

PMID: 19679083

Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.

Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW

Proteins. 76(2):507-11. doi: 10.1002/prot.22411

Publication date: August 1, 2009

PMID: 19360879

Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors.

Choi Y, Syeda F, Walker JR, Finerty PJ, Cuerrier D, Wojciechowski A, Liu Q, Dhe-Paganon S, Gray NS

Bioorg. Med. Chem. Lett.. 19(15):4467-70. doi: 10.1016/j.bmcl.2009.05.029

Publication date: August 1, 2009

PMID: 19553108

Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.

Beswick PJ, Blackaby AP, Bountra C, Brown T, Browning K, Campbell IB, Corfield J, Gleave RJ, Guntrip SB, Hall RM, Hindley S, Lambeth PF, Lucas F, Mathews N, Naylor A, Player H, Price HS, Sidebottom PJ, Taylor NL, Webb G, Wiseman J

Bioorg. Med. Chem. Lett.. 19(15):4509-14. doi: 10.1016/j.bmcl.2009.02.089

Publication date: August 1, 2009

PMID: 19523822

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

Swarbrick ME, Beswick PJ, Gleave RJ, Green RH, Bingham S, Bountra C, Carter MC, Chambers LJ, Chessell IP, Clayton NM, Collins SD, Corfield JA, Hartley CD, Kleanthous S, Lambeth PF, Lucas FS, Mathews N, Naylor A, Page LW, Payne JJ, Pegg NA, Price HS, Skidmore J, Stevens AJ, Stocker R, Stratton SC, Stuart AJ, Wiseman JO

Bioorg. Med. Chem. Lett.. 19(15):4504-8. doi: 10.1016/j.bmcl.2009.02.085

Publication date: August 1, 2009

PMID: 19520573

Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP

J. Biol. Chem.. 284(29):19402-11. doi: 10.1074/jbc.M109.024711

Publication date: July 17, 2009

PMID: 19478087

Crystal structure of human diphosphoinositol phosphatase 1.

Thorsell AG, Persson C, Gräslund S, Hammarström M, Busam RD, Hallberg BM

Proteins. 77(1):242-6. doi: 10.1002/prot.22489

Publication date: July 9, 2009

PMID: 19585659

Substrate recognition and hydrolysis by a fungal xyloglucan-specific family 12 hydrolase.

Powlowski J, Mahajan S, Schapira M, Master ER

Carbohydr. Res.. 344(10):1175-9. doi: 10.1016/j.carres.2009.04.020

Publication date: July 6, 2009

PMID: 19433323

Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.

Bunkoczi G, Misquitta S, Wu X, Lee WH, Rojkova A, Kochan G, Kavanagh KL, Oppermann U, Smith S

Chem. Biol.. 16(6):667-75. doi: 10.1016/j.chembiol.2009.04.011

Publication date: June 26, 2009

PMID: 19549604

Open access chemical and clinical probes to support drug discovery.

Edwards AM, Bountra C, Kerr DJ, Willson TM

Nat. Chem. Biol.. 5(7):436-40. doi: 10.1038/nchembio0709-436

Publication date: June 19, 2009

PMID: 19536100

Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3.

Porté S, Valencia E, Yakovtseva EA, Borràs E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farrés J, Fita I, Parés X

J. Biol. Chem.. 284(25):17194-205. doi: 10.1074/jbc.M109.001800

Publication date: June 19, 2009

PMID: 19349281

Crystal structures of human CDY proteins reveal a crotonase-like fold.

Wu H, Min J, Antoshenko T, Plotnikov AN

Proteins. 76(4):1054-61. doi: 10.1002/prot.22472

Publication date: June 10, 2009

PMID: 19507244

Large-scale structural biology of the human proteome.

Edwards A

Annu. Rev. Biochem.. 78:541-68. doi: 10.1146/annurev.biochem.78.070907.103305

Publication date: June 6, 2009

PMID: 19489729

Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis.

Sibley LD, Qiu W, Fentress S, Taylor SJ, Khan A, Hui R

Eukaryotic Cell. 8(8):1085-93. doi: 10.1128/EC.00107-09

Publication date: May 22, 2009

PMID: 19465561

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.

Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW

J. Mol. Biol.. 388(5):997-1008. doi: 10.1016/j.jmb.2009.03.064

Publication date: May 22, 2009

PMID: 19345228

Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.

Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC

J Biomol Screen. 14(6):700-7. doi: 10.1177/1087057109335749

Publication date: May 21, 2009

PMID: 19470714

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.

Lehtiö L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarström M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schüler H, Karlberg T

J. Med. Chem.. 52(9):3108-11. doi: 10.1021/jm900052j

Publication date: May 14, 2009

PMID: 19354255

Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.

Huck K, Feyen O, Niehues T, Rüschendorf F, Hübner N, Laws HJ, Telieps T, Knapp S, Wacker HH, Meindl A, Jumaa H, Borkhardt A

J. Clin. Invest.. 119(5):1350-8. doi: 10.1172/JCI37901

Publication date: May 9, 2009

PMID: 19425169

The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.

Collins R, Karlberg T, Lehtiö L, Schütz P, van den Berg S, Dahlgren LG, Hammarström M, Weigelt J, Schüler H

J. Biol. Chem.. 284(16):10296-300. doi: 10.1074/jbc.C900018200

Publication date: April 17, 2009

PMID: 19244245

Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes.

Min T, Vedadi M, Watson DC, Wasney GA, Munger C, Cygler M, Matte A, Young NM

Biochemistry. 48(14):3057-67. doi: 10.1021/bi802195d

Publication date: April 14, 2009

PMID: 19236052

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.

Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD

EMBO J.. 28(7):969-79. doi: 10.1038/emboj.2009.24

Publication date: April 8, 2009

PMID: 19197235

In situ proteolysis to generate crystals for structure determination: an update.

Wernimont A, Edwards A

PLoS ONE. 4(4):e5094. doi: 10.1371/journal.pone.0005094

Publication date: April 7, 2009

PMID: 19352432

HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.

Gingras MC, Zhang YL, Kharitidi D, Barr AJ, Knapp S, Tremblay ML, Pause A

PLoS ONE. 4(4):e5105. doi: 10.1371/journal.pone.0005105

Publication date: April 2, 2009

PMID: 19340315

Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients.

Petrie KA, Lee WH, Bullock AN, Pointon JJ, Smith R, Russell RG, Brown MA, Wordsworth BP, Triffitt JT

PLoS ONE. 4(3):e5005. doi: 10.1371/journal.pone.0005005

Publication date: March 30, 2009

PMID: 19330033

Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.

Hult M, Ortsäter H, Schuster G, Graedler F, Beckers J, Adamski J, Ploner A, Jörnvall H, Bergsten P, Oppermann U

Mol. Cell. Endocrinol.. 301(1-2):109-16. doi: 10.1016/j.mce.2008.09.038

Publication date: March 25, 2009

PMID: 18984029

Structure of dystrophia myotonica protein kinase.

Elkins JM, Amos A, Niesen FH, Pike AC, Fedorov O, Knapp S

Protein Sci.. 18(4):782-91. doi: 10.1002/pro.82

Publication date: March 25, 2009

PMID: 19309729

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U

Mol. Cell. Endocrinol.. 301(1-2):199-204. doi: 10.1016/j.mce.2008.09.042

Publication date: March 25, 2009

PMID: 19013211