Publications | Structural Genomics Consortium

Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ

Bioorg. Med. Chem. Lett.. 20(11):3387-93. doi: 10.1016/j.bmcl.2010.04.015

Publication date: June 1, 2010

PMID: 20451379

Towards proteome scale antibody selections using phage display.

Mersmann M, Meier D, Mersmann J, Helmsing S, Nilsson P, Gräslund S, Colwill K, Hust M, Dübel S

N Biotechnol. 27(2):118-28. doi: 10.1016/j.nbt.2009.10.007

Publication date: May 31, 2010

PMID: 19883803

Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR

J. Biol. Chem.. 285(21):16218-30. doi: 10.1074/jbc.M109.070953

Publication date: May 21, 2010

PMID: 20207729

Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

Hong BS, Allali-Hassani A, Tempel W, Finerty PJ, Mackenzie F, Dimov S, Vedadi M, Park HW

J. Biol. Chem.. 285(21):16330-40. doi: 10.1074/jbc.M109.039024

Publication date: May 21, 2010

PMID: 20299452

Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.

Jörnvall H, Hedlund J, Bergman T, Oppermann U, Persson B

Biochem. Biophys. Res. Commun.. 396(1):125-30. doi: 10.1016/j.bbrc.2010.03.094

Publication date: May 21, 2010

PMID: 20494124

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.

Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD

Nature. 465(7296):359-62. doi: 10.1038/nature09022

Publication date: May 20, 2010

PMID: 20485436

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW

J. Mol. Biol.. 398(4):497-506. doi: 10.1016/j.jmb.2010.03.034

Publication date: May 14, 2010

PMID: 20346956

Biophysical characterization of recombinant proteins: a key to higher structural genomics success.

Vedadi M, Arrowsmith CH, Allali-Hassani A, Senisterra G, Wasney GA

J. Struct. Biol.. 172(1):107-19. doi: 10.1016/j.jsb.2010.05.005

Publication date: May 11, 2010

PMID: 20466062

A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

Quinn AM, Allali-Hassani A, Vedadi M, Simeonov A

Mol Biosyst. 6(5):782-8. doi: 10.1039/b921912a

Publication date: May 10, 2010

PMID: 20567762

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.

Wernimont AK, Artz JD, Finerty P, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R

Nat. Struct. Mol. Biol.. 17(5):596-601. doi: 10.1038/nsmb.1795

Publication date: May 2, 2010

PMID: 20436473

Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite.

Huttu J, Singh BK, Bhargav SP, Sattler JM, Schüler H, Kursula I

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 66(Pt 5):583-7. doi: 10.1107/S1744309110011589

Publication date: May 1, 2010

PMID: 20445265

Structural genomics-impact on biomedicine and drug discovery.

Weigelt J

Exp. Cell Res.. 316(8):1332-8. doi: 10.1016/j.yexcr.2010.02.041

Publication date: May 1, 2010

PMID: 20211166

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.

Kallberg Y, Oppermann U, Persson B

FEBS J.. 277(10):2375-86. doi: 10.1111/j.1742-4658.2010.07656.x

Publication date: April 29, 2010

PMID: 20423462

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

López-Ramos M, Prudent R, Moucadel V, Sautel CF, Barette C, Lafanechère L, Mouawad L, Grierson D, Schmidt F, Florent JC, Filippakopoulos P, Bullock AN, Knapp S, Reiser JB, Cochet C

FASEB J.. 24(9):3171-85. doi: 10.1096/fj.09-143743

Publication date: April 16, 2010

PMID: 20400536

Finding Inspiration in the Protein Data Bank to Chemically Antagonize Readers of the Histone Code.

Campagna-Slater V, Schapira M

Mol Inform. 29(4):322-31. doi: 10.1002/minf.201000018

Publication date: April 12, 2010

PMID: 27463059

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS

Nat. Chem. Biol.. 6(5):359-68. doi: 10.1038/nchembio.345

Publication date: April 11, 2010

PMID: 20383151

Structural basis of human CYP51 inhibition by antifungal azoles.

Strushkevich N, Usanov SA, Park HW

J. Mol. Biol.. 397(4):1067-78. doi: 10.1016/j.jmb.2010.01.075

Publication date: April 9, 2010

PMID: 20149798

Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.

Hliscs M, Sattler JM, Tempel W, Artz JD, Dong A, Hui R, Matuschewski K, Schüler H

J. Biol. Chem.. 285(15):11572-83. doi: 10.1074/jbc.M109.054916

Publication date: April 9, 2010

PMID: 20083609

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG

Nature. 464(7289):728-32. doi: 10.1038/nature08893

Publication date: April 1, 2010

PMID: 20360736

Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity.

Zhao R, Leung E, Grüner S, Schapira M, Houry WA

PLoS ONE. 5(4):e9934. doi: 10.1371/journal.pone.0009934

Publication date: April 1, 2010

PMID: 20376192

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F

Trends Biochem. Sci.. 35(4):208-19. doi: 10.1016/j.tibs.2009.12.003

Publication date: April 1, 2010

PMID: 20106667

Pharmacophore screening of the protein data bank for specific binding site chemistry.

Campagna-Slater V, Arrowsmith AG, Zhao Y, Schapira M

J Chem Inf Model. 50(3):358-67. doi: 10.1021/ci900427b

Publication date: March 22, 2010

PMID: 20112952

Probing the structural basis of RecQ helicase function.

Vindigni A, Marino F, Gileadi O

Biophys. Chem.. 149(3):67-77. doi: 10.1016/j.bpc.2010.03.012

Publication date: March 20, 2010

PMID: 20392558

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.

Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD

Blood. 115(11):2251-9. doi: 10.1182/blood-2009-07-231191

Publication date: March 18, 2010

PMID: 20075161

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T

J. Biol. Chem.. 285(11):8054-60. doi: 10.1074/jbc.M109.077834

Publication date: March 12, 2010

PMID: 20064938

Open-access public-private partnerships to enable drug discovery--new approaches.

Müller S, Weigelt J

IDrugs. 13(3):175-80.

Publication date: March 2, 2010

PMID: 20191434

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ

J. Med. Chem.. 53(4):1810-8. doi: 10.1021/jm901680b

Publication date: February 25, 2010

PMID: 20088513

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA

FEBS Lett.. 584(4):825-30. doi: 10.1016/j.febslet.2009.12.055

Publication date: February 19, 2010

PMID: 20067792

Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.

Pershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J

Protein Eng. Des. Sel.. 23(4):279-88. doi: 10.1093/protein/gzq003

Publication date: February 17, 2010

PMID: 20164216

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

Karlberg T, Hammarström M, Schütz P, Svensson L, Schüler H

Biochemistry. 49(6):1056-8. doi: 10.1021/bi902079y

Publication date: February 16, 2010

PMID: 20092359

The (un)targeted cancer kinome.

Fedorov O, Müller S, Knapp S

Nat. Chem. Biol.. 6(3):166-169. doi: 10.1038/nchembio.297

Publication date: February 16, 2010

PMID: 20154661

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

Senisterra GA, Ghanei H, Khutoreskaya G, Dobrovetsky E, Edwards AM, Privé GG, Vedadi M

J Biomol Screen. 15(3):314-20. doi: 10.1177/1087057109357117

Publication date: February 11, 2010

PMID: 20150591

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ

J. Med. Chem.. 53(3):1048-55. doi: 10.1021/jm901577g

Publication date: February 11, 2010

PMID: 20017496

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers.

Brault L, Gasser C, Bracher F, Huber K, Knapp S, Schwaller J

Haematologica. 95(6):1004-15. doi: 10.3324/haematol.2009.017079

Publication date: February 9, 2010

PMID: 20145274

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.

Littler DR, Walker JR, Davis T, Wybenga-Groot LE, Finerty PJ, Newman E, Mackenzie F, Dhe-Paganon S

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 66(Pt 2):143-51. doi: 10.1107/S1744309109052543

Publication date: February 1, 2010

PMID: 20124709

A miniaturized screen for inhibitors of Jumonji histone demethylases.

Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A

Mol Biosyst. 6(2):357-64. doi: 10.1039/b912993f

Publication date: January 21, 2010

PMID: 20094655

A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.

Rauschenberger K, Schöler K, Sass JO, Sauer S, Djuric Z, Rumig C, Wolf NI, Okun JG, Kölker S, Schwarz H, Fischer C, Grziwa B, Runz H, Nümann A, Shafqat N, Kavanagh KL, Hämmerling G, Wanders RJ, Shield JP, Wendel U, Stern D, Nawroth P, Hoffmann GF, Bartram CR, Arnold B, Bierhaus A, Oppermann U, Steinbeisser H, Zschocke J

EMBO Mol Med. 2(2):51-62. doi: 10.1002/emmm.200900055

Publication date: January 16, 2010

PMID: 20077426

UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.

Bronner C, Fuhrmann G, Chédin FL, Macaluso M, Dhe-Paganon S

Genet Epigenet. 2009(2):29-36.

Publication date: January 14, 2010

PMID: 21643543

Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

Wisniewska M, Karlberg T, Lehtiö L, Johansson I, Kotenyova T, Moche M, Schüler H

PLoS ONE. 5(1):e8625. doi: 10.1371/journal.pone.0008625

Publication date: January 11, 2010

PMID: 20072699

Structural biology of human H3K9 methyltransferases.

Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M

PLoS ONE. 5(1):e8570. doi: 10.1371/journal.pone.0008570

Publication date: January 11, 2010

PMID: 20084102

Structure and function of the PLAA/Ufd3-p97/Cdc48 complex.

Qiu L, Pashkova N, Walker JR, Winistorfer S, Allali-Hassani A, Akutsu M, Piper R, Dhe-Paganon S

J. Biol. Chem.. 285(1):365-72. doi: 10.1074/jbc.M109.044685

Publication date: January 1, 2010

PMID: 19887378

Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, Arrowsmith CH, Brown PJ, Simeonov A, Vedadi M, Jin J

J. Med. Chem.. 52(24):7950-3. doi: 10.1021/jm901543m

Publication date: December 24, 2009

PMID: 19891491

Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.

Tong Y, Hota PK, Penachioni JY, Hamaneh MB, Kim S, Alviani RS, Shen L, He H, Tempel W, Tamagnone L, Park HW, Buck M

J. Biol. Chem.. 284(51):35962-72. doi: 10.1074/jbc.M109.056275

Publication date: December 18, 2009

PMID: 19843518

Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins.

Wigle TJ, Herold JM, Senisterra GA, Vedadi M, Kireev DB, Arrowsmith CH, Frye SV, Janzen WP

J Biomol Screen. 15(1):62-71. doi: 10.1177/1087057109352902

Publication date: December 11, 2009

PMID: 20008125

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T

Proc. Natl. Acad. Sci. U.S.A.. 106(48):20336-41. doi: 10.1073/pnas.0911640106

Publication date: December 1, 2009

PMID: 19918066

Structure and functional characterization of the atypical human kinase haspin.

Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JM, Knapp S

Proc. Natl. Acad. Sci. U.S.A.. 106(48):20198-203. doi: 10.1073/pnas.0901989106

Publication date: December 1, 2009

PMID: 19918057