Publications

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Displaying 2051 - 2100 of 2244

2007

July 2007

Activation segment exchange: a common mechanism of kinase autophosphorylation?
Oliver AW, Knapp S, Pearl LH
Trends Biochem. Sci. 32(8):351-6 . doi: 10.1016/j.tibs.2007.06.004
Publication date: July 12, 2007
PMID: 17627826
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U
Nature 448(7149):87-91 . doi: 10.1038/nature05971
Publication date: July 5, 2007
PMID: 17589501
Crystallization and preliminary X-ray analysis of phage Mu activator protein C in a complex with promoter DNA.
Shanmuganatham KK, Ravichandran M, Howe MM, Park HW
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 7):620-3 . doi: 10.1107/S1744309107025286
Publication date: July 1, 2007
PMID: 17620727
Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A.
Schuetz A, Bernstein G, Dong A, Antoshenko T, Wu H, Loppnau P, Bochkarev A, Plotnikov AN
Proteins 68(1):403-7 . doi: 10.1002/prot.21407
Publication date: July 1, 2007
PMID: 17410582

June 2007

Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
Xia, Z; Dunford, J; Lawson, MA; Triffitt, JT; Kavanagh, K; Oppermann, U; Barnett, BL; Ebetino, FH; Russell, RGG;
Journal of Bone and Mineral Research 22:1125-1125 . doi:
Publication date: June 30, 2007
PMID:
Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition.
Walldén K, Stenmark P, Nyman T, Flodin S, Gräslund S, Loppnau P, Bianchi V, Nordlund P
J. Biol. Chem. 282(24):17828-36 . doi: 10.1074/jbc.M700917200
Publication date: June 15, 2007
PMID: 17405878
Atomic resolution insight into host cell recognition by Toxoplasma gondii.
Blumenschein, TMA; Friedrich, N; Childs, RA; Saouros, S; Carpenter, EP; Campanero-Rhodes, MA; Simpson, P; Chai, W; Koutroukides, T; Blackman, MJ; Feizi, T; Soldati-Favre, D; Matthews, S;
EMBO Journal 26:2808-2820 . doi: 10.1038/sj.emboj.7601704
Publication date: June 5, 2007
PMID: 17491595
Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator.
Lorca GL, Ezersky A, Lunin VV, Walker JR, Altamentova S, Evdokimova E, Vedadi M, Bochkarev A, Savchenko A
J. Biol. Chem. 282(22):16476-91 . doi: 10.1074/jbc.M610838200
Publication date: June 1, 2007
PMID: 17426033

May 2007

Breast cancer stem cells: Potential therapeutic targets
Howell, SJ; Farnie, G; Clarke, RB;
Advances in Breast Cancer -London- 4:51-53 . doi:
Publication date: May 31, 2007
PMID:
Mammary stem cells and breast cancer--role of Notch signalling.
Farnie, G; Clarke, RB;
Stem Cell Reviews and Reports 3:169-175 . doi: 10.1007/s12015-007-0023-5
Publication date: May 31, 2007
PMID: 17873349
Predicting pharmacological potencies of nitrogen-containing bisphosphonates; novel methods dissociate enzyme- and hydroxyapatite-binding affinities
Xia, Z; Dunford, J; Lawson, MA; Triffitt, JT; Kavanagh, K; Oppermann, U; Roze, C; Kashemirov, B; McKenna, CE; Ebetino, FH; Russell, RG;
BONE 40:S301-S302 . doi:
Publication date: May 31, 2007
PMID:
Protein-protein interaction site mapping using NMR-detected mutational scanning
Baminger, B; Ludwiczek, ML; Kontaxis, G; Knapp, S; Konrat, R;
Journal of Biomolecular NMR 38:133-137 . doi: 10.1007/s10858-007-9154-x
Publication date: May 31, 2007
PMID: 17447011
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites.
Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR
J. Biol. Chem. 282(21):15667-78 . doi: 10.1074/jbc.M700253200
Publication date: May 25, 2007
PMID: 17392278
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites
Rennefahrt, UEE; Deacon, SW; Parker, SA; Devarajan, K; Beeser, A; Chernoff, J; Knapp, S; Turk, BE; Peterson, JR;
Journal of Biological Chemistry 282:15667-15678 . doi: 10.1074/jbc.M700253200
Publication date: May 24, 2007
PMID: 17392278
Hexagonal close packing of nonionic surfactant micelles in water.
Zeng X, Liu Y, Impéror-Clerc M
J Phys Chem B 111(19):5174-9 . doi: 10.1021/jp0687955
Publication date: May 17, 2007
PMID: 17429992
Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.
Grosfeld A, Stolze IP, Cockman ME, Pugh CW, Edelmann M, Kessler B, Bullock AN, Ratcliffe PJ, Masson N
J. Biol. Chem. 282(18):13264-9 . doi: 10.1074/jbc.M611648200
Publication date: May 4, 2007
PMID: 17339318
Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD
J. Mol. Biol. 368(3):691-705 . doi: 10.1016/j.jmb.2007.02.019
Publication date: May 4, 2007
PMID: 17368478
Interaction of hydroxylated collagen IV with the von-Hippel-Lindau tumor suppressor.
Masson, N; Grosfeld A, ; Kessler B, ; Ratcliffe PJ, ;
Journal of Biological Chemistry 282:13264-13269 . doi: 10.1074/jbc.M611648200
Publication date: May 3, 2007
PMID: 17339318

April 2007

Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse.
Endt, J; McCann, FE; Almeida, CR; Urlaub, D; Leung, R; Pende, D; Davis, DM; Watzl, C;
Journal of Immunology 178:5606-5611 . doi: 10.4049/jimmunol.178.9.5606
Publication date: April 30, 2007
PMID: 17442943
Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.
Howard-Jones, AR; Elkins, JM; Clifton, IJ; Roach, PL; Adlington, RM; Baldwin, JE; Rutledge, PJ;
Biochemistry 46:4755-4762 . doi: 10.1021/bi062314q
Publication date: April 23, 2007
PMID: 17397141
Protein-protein interaction site mapping using NMR-detected mutational scanning.
Baminger B, Ludwiczek ML, Kontaxis G, Knapp S, Konrat R
J. Biomol. NMR 38(2):133-7 . doi: 10.1007/s10858-007-9154-x
Publication date: April 20, 2007
PMID: 17447011
Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.
Farnie, G; Clarke, RB; Spence, K; Pinnock, N; Brennan, K; Anderson, NG; Bundred, NJ;
JNCI: Journal of the National Cancer Institute 99:616-627 . doi: 10.1093/jnci/djk133
Publication date: April 17, 2007
PMID: 17440163
Structural and chemical profiling of the human cytosolic sulfotransferases.
Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH
PLoS Biol. 5(5):e97 . doi: 10.1371/journal.pbio.0050097
Publication date: April 12, 2007
PMID: 17425406
Structural basis of allele variation of human thiopurine-S-methyltransferase.
Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X
Proteins 67(1):198-208 . doi: 10.1002/prot.21272
Publication date: April 1, 2007
PMID: 17243178

March 2007

Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.
Staton, PC; Wilson, AW; Bountra, C; Chessell, IP; Day, NC;
European Journal of Pain 11:283-289 . doi: 10.1016/j.ejpain.2006.03.006
Publication date: March 31, 2007
PMID: 16690336
Clinical and experimental pain processing in rheumatoid arthritis patients treated with anti-TNF
Wartolowska, K; Schweinhardt, P; Wordsworth, P; Chizh, BA; Bountra, C; Chessell, I; Tracey, I;
Rheumatology 46:I6-I7 . doi:
Publication date: March 31, 2007
PMID:
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Elkins, JM; Papagrigoriou, E; Berridge, G; Yang, X; Phillips, C; Gileadi, C; Savitsky, P; Doyle, DA;
Protein Science 16:683-694 . doi:
Publication date: March 31, 2007
PMID: 17384233
Insights for the development of specific kinase inhibitors by targeted structural genomics.
Fedorov O, Sundström M, Marsden B, Knapp S
Drug Discov. Today 12(9-10):365-72 . doi: 10.1016/j.drudis.2007.03.006
Publication date: March 29, 2007
PMID: 17467572
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.
Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN
Structure 15(3):377-89 . doi: 10.1016/j.str.2007.02.002
Publication date: March 16, 2007
PMID: 17355872
The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.
McCann, FE; Eissmann, P; Onfelt, B; Leung, R; Davis, DM;
Journal of Immunology 178:3418-3426 . doi: 10.4049/jimmunol.178.6.3418
Publication date: March 15, 2007
PMID: 17339436
Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection
Wagner CS, Riise GC, Bergstrom T, Karre K, Carbone E, Berg L.
J Immunol. 178(6):3536-43 . doi: 10.4049/jimmunol.178.6.3536
Publication date: March 15, 2007
PMID: 17339449
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Kavanagh K, Lee WH, Hwa Lee W, Adamski J, Oppermann U
Biochem. J. 402(3):419-27 . doi: 10.1042/BJ20061319
Publication date: March 15, 2007
PMID: 17067289
A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.
Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP
J. Med. Chem. 50(5):915-21 . doi: 10.1021/jm060827p
Publication date: March 8, 2007
PMID: 17290979
AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.
Carpenter, EP; Corbett, A; Thomson, H; Adacha, J; Jensen, K; Bergeron, J; Kasampalidis, I; Exley, R; Winterbotham, M; Tang, C; Baldwin, GS; Freemont, P;
EMBO Journal 26:1363-1372 . doi: 10.1038/sj.emboj.7601593
Publication date: March 7, 2007
PMID: 17318183
Structure and regulation of the human Nek2 centrosomal kinase.
Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Fedorov O, Shen QY, Fry AM, Knapp S, Smerdon SJ
J. Biol. Chem. 282(9):6833-42 . doi: 10.1074/jbc.M609721200
Publication date: March 2, 2007
PMID: 17197699
An NMR-based metabolic profiling study of inflammatory pain using the rat FCA model
Connor, SC; Gray, RA; Hodson, MP; Clayton, NM; Haselden, JN; Chessell, IP; Bountra, C;
Metabolomics 3:29-39 . doi: 10.1007/s11306-006-0039-x
Publication date: March 1, 2007
PMID:
Structural genomics and drug discovery: Case studies on human metabolic enzymes
Oppermann, U; Kavanagh, KL; Guo, K; Ng, S; Shafqat, N; Danford, J; Rojkova, A; Pilka, E; Hozjan, V; Kochan, G; Wu, X; Lukacik, P;
Naunyn-Schmiedeberg's Archives of Pharmacology 375:69-69 . doi:
Publication date: March 1, 2007
PMID:

February 2007

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities.
Wu X, Knapp S, Stamp A, Stammers DK, Jörnvall H, Dellaporta SL, Oppermann U
FEBS J. 274(5):1172-82 . doi: 10.1111/j.1742-4658.2007.05642.x
Publication date: February 15, 2007
PMID: 17298439
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR, Knapp S
Structure 15(2):201-13 . doi: 10.1016/j.str.2007.01.001
Publication date: February 13, 2007
PMID: 17292838
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Davis TL, Walker JR, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S
J. Mol. Biol. 366(1):216-29 . doi: 10.1016/j.jmb.2006.11.037
Publication date: February 9, 2007
PMID: 17157313
Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer.
Barnes, NLP; Warnberg, F; Farnie, G; White, D; Jiang, W; Anderson, E; Bundred, NJ;
British Journal of Cancer 96:575-582 . doi: 10.1038/sj.bjc.6603593
Publication date: February 6, 2007
PMID: 17285134
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.
Johansson C, Kavanagh KL, Gileadi O, Oppermann U
J. Biol. Chem. 282(5):3077-82 . doi: 10.1074/jbc.M608179200
Publication date: February 2, 2007
PMID: 17121859
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.
Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H
J. Biol. Chem. 282(5):3182-7 . doi: 10.1074/jbc.M609838200
Publication date: February 2, 2007
PMID: 17138556
The centaurin gamma-1 GTPase-like domain functions as an NTPase.
Soundararajan, M; Yang, X; Elkins, JM; Sobott, F; Doyle, DA;
Biochemical Journal 401:679-688 . doi: 10.1042/BJ20060555
Publication date: February 1, 2007
PMID: 17037982
The effect of inflammation on Fos expression in the ferret trigeminal nucleus.
Worsley, MA; Davies, SL; Clayton, NM; Bountra, C; Loescher, AR; Robinson, PP; Boissonade, FM;
European Journal of Oral Sciences 115:40-47 . doi: 10.1111/j.1600-0722.2007.00411.x
Publication date: February 1, 2007
PMID: 17305715

January 2007

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.
Wu X, Lukacik P, Kavanagh KL, Oppermann U
Mol. Cell. Endocrinol. 265-266:71-6 . doi: 10.1016/j.mce.2006.12.006
Publication date: January 17, 2007
PMID: 17234335
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy.
Sánchez, D; Anand, U; Gorelik, J; Benham, CD; Bountra, C; Lab, M; Klenerman, D; Birch, R; Anand, P; Korchev, Y;
Journal of Neuroscience Methods 159:26-34 . doi: 10.1016/j.jneumeth.2006.06.018
Publication date: January 15, 2007
PMID: 16887195
Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family.
Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovsky L, Pan PW, Vedadi M, Plotnikov AN, Edwards A, Arrowsmith C, Thornton JM
Bioinformatics 23(2):e104-9 . doi: 10.1093/bioinformatics/btl292
Publication date: January 15, 2007
PMID: 17237076
Total Synthesis of Rapamycin
Maddess, ML; Tackett, MN; Watanabe, H; Brennan, PE; Spilling, CD; Scott, JS; Osborn, DP; Ley, SV;
Angewandte Chemie International Edition 46:591-597 . doi: 10.1002/anie.200604053
Publication date: January 15, 2007
PMID:
Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
Vogler, M; Dürr, K; Jovanovic, M; Debatin, K-M; Fulda, S;
Oncogene 26:248-257 . doi: 10.1038/sj.onc.1209776
Publication date: January 11, 2007
PMID:

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