Publications | Structural Genomics Consortium

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.

Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U

J. Biol. Chem.. 281(15):10291-7. doi: 10.1074/jbc.M511346200

Publication date: April 14, 2006

PMID: 16380372

Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.

Hult M, Shafqat N, Elleby B, Mitschke D, Svensson S, Forsgren M, Barf T, Vallgårda J, Abrahmsen L, Oppermann U

Mol. Cell. Endocrinol.. 248(1-2):26-33. doi: 10.1016/j.mce.2005.11.043

Publication date: March 27, 2006

PMID: 16431016

Structure and function of human 17beta-hydroxysteroid dehydrogenases.

Lukacik P, Kavanagh KL, Oppermann U

Mol. Cell. Endocrinol.. 248(1-2):61-71. doi: 10.1016/j.mce.2005.12.007

Publication date: March 27, 2006

PMID: 16414178

Ruthenium half-sandwich complexes bound to protein kinase Pim-1.

Debreczeni JE, Bullock AN, Atilla GE, Williams DS, Bregman H, Knapp S, Meggers E

Angew. Chem. Int. Ed. Engl.. 45(10):1580-5. doi: 10.1002/anie.200503468

Publication date: February 27, 2006

PMID: 16381041

Disseminating structural genomics data to the public: from a data dump to an animated story.

Abagyan R, Lee WH, Raush E, Budagyan L, Totrov M, Sundstrom M, Marsden BD

Trends Biochem. Sci.. 31(2):76-8. doi: 10.1016/j.tibs.2005.12.006

Publication date: January 6, 2006

PMID: 16406633

Structure and substrate specificity of the Pim-1 kinase.

Bullock AN, Debreczeni J, Amos AL, Knapp S, Turk BE

J. Biol. Chem.. 280(50):41675-82. doi: 10.1074/jbc.M510711200

Publication date: December 16, 2005

PMID: 16227208

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ

J. Biol. Chem.. 280(49):41101-10. doi: 10.1074/jbc.M507528200

Publication date: December 9, 2005

PMID: 16186124

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

Bullock AN, Debreczeni JE, Fedorov OY, Nelson A, Marsden BD, Knapp S

J. Med. Chem.. 48(24):7604-14. doi: 10.1021/jm0504858

Publication date: December 1, 2005

PMID: 16302800

Regulation of the wild-type and Y1235D mutant Met kinase activation.

Cristiani C, Rusconi L, Perego R, Schiering N, Kalisz HM, Knapp S, Isacchi A

Biochemistry. 44(43):14110-9. doi: 10.1021/bi051242k

Publication date: November 1, 2005

PMID: 16245927

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

Ogg D, Elleby B, Norström C, Stefansson K, Abrahmsén L, Oppermann U, Svensson S

J. Biol. Chem.. 280(5):3789-94. doi: 10.1074/jbc.M412463200

Publication date: February 4, 2005

PMID: 15542590