Publications | Structural Genomics Consortium

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1.

Hank EC, D'Arcy-Evans ND, Scaletti ER, Benítez-Buelga C, Wallner O, Ortis F, Zhou K, Meng L, Del Prado A, Calvo P, Almlöf I, Wiita E, Nierlin K, Košenina S, Krämer A, Eddershaw A, Kehler M, Long M, Jemth AS, Dawson H, Stewart J, Dickey A, Astorga ME, Varga M, Homan EJ, Scobie M, Knapp S, Sastre L, Stenmark P, de Vega M, Helleday T, Michel M

RSC Chem Biol. doi: 10.1039/d4cb00323c

Publication date: November 6, 2025

PMID: 41195166

Nucleosome context regulates chromatin reader preference.

Marunde MR, Popova IK, Hall NW, Vaidya A, Bone JR, Boone BA, Brown PJ, Ezell RJ, Firestone TM, Fuchs HA, Gibson E, Gillespie ZB, Gloor SL, Hickman AR, Howard SA, Husby NL, Hsiung VT, Johnstone AL, Khan LF, Krajewski K, Lee AS, McAnarney ET, Maier KE, Maryanski DN, McCuiston JL, Noll KE, Novitzky K, Patteson EF, Rodriguez KL, Sanchez JC, Schachner LF, Smith CE, Sun L, Taylor HF, Watson R, Willis HE, Musselman CA, Venters BJ, Cheek MA, Meiners MJ, Sun ZW, Kelleher NL, Cowles MW, Weinzapfel EN, Keogh MC, Burg JM

Nucleic Acids Res. 53(20):. doi: 10.1093/nar/gkaf1061

Publication date: November 3, 2025

PMID: 41182902

NEK Family Kinases: Structure, Function, and Role in Disease.

Baker BM, Boehling JR, Knopf S, Held S, Matossian M, Belgodere JA, Hoang VT, Collins-Burow BM, Martin EC, Lee SB, Burow ME, Drewry DH, Newman RH

Biomolecules. 15(10):. doi: 10.3390/biom15101406

Publication date: October 29, 2025

PMID: 41154634

Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression.

Zhang M, Chen M, Li P, Min J

Cell Chem Biol. doi: 10.1016/j.chembiol.2025.10.002

Publication date: October 25, 2025

PMID: 41135522

GraphComm predicts cell cell communication using a graph based deep learning method in single cell RNA sequencing data.

So E, Hayat S, Nair SK, Wang B, Haibe-Kains B

Sci Rep. 15(1):36914. doi: 10.1038/s41598-025-20812-1

Publication date: October 23, 2025

PMID: 41125721

Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach.

Schönfeld J, Liebisch N, Brunst S, Weizel L, Knapp S, Kannt A, Proschak E, Hiesinger K

Chem Commun (Camb). doi: 10.1039/d5cc03325j

Publication date: October 22, 2025

PMID: 41120092

Structure-activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis, the main causative agent of mycetoma.

Duong HP, Melechov D, Lim W, Ma J, Scroggie KR, Rajendra L, Perry B, Cruz LR, Saleem RSZ, Rutledge PJ, Motion A, van de Sande WWJ, Todd MH

RSC Med Chem. doi: 10.1039/d5md00427f

Publication date: October 20, 2025

PMID: 41113115

Cysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death.

Gotthardt G, Weckesser J, Tascher G, Barros da Gama S, Uckelmann HJ, Sun S, Schwalm MP, Mosler T, Ferrario G, Friedmann Angeli JP, Münch C, Knapp S, Müller S

EMBO Rep. doi: 10.1038/s44319-025-00593-4

Publication date: October 17, 2025

PMID: 41102521

N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity.

Ghoshal A, Sears JD, Hossain MA, Tse EG, Howell S, Burdick JE, Morales NL, Martinez SA, Law I, Streblow ZJ, Streblow DN, Couñago RM, Moorman NJ, Heise MT, Willson TM

J Med Chem. doi: 10.1021/acs.jmedchem.5c01802

Publication date: October 15, 2025

PMID: 41090377

Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders.

Wellnitz J, Ahmad S, Bagale N, Cheng X, Joseph J, Zeng H, Bolotokova A, Dong A, Reza S, Ghiabi P, Gibson E, Tu G, Li X, Liu J, Dou D, Li J, Foley TL, Harris AR, Klug-McLeod JL, Lee J, Lengyel-Zhand Z, Montgomery JI, Sakata S, Zhang J, Zhu H, Owen DR, Harding RJ, Edwards AM, Haibe-Kains B, Halabelian L, Tropsha A, Couñago RM

J Med Chem. doi: 10.1021/acs.jmedchem.5c01972

Publication date: October 6, 2025

PMID: 41047897

A needed nomenclature for nucleosomes.

Keogh MC, Almouzni G, Andrews AJ, Armache KJ, Arrowsmith CH, Baek SH, Bedford MT, Bernstein E, Côté J, David Y, Denu JM, Fierz B, Garcia BA, Glass KC, Gozani O, Helin K, Henikoff S, Jensen ON, Josefowicz SZ, Kelleher NL, Kutateladze TG, Lindner HH, Lu C, Luger K, Mallick P, Musselman CA, Muir TW, Paša-Tolić L, Schneider R, Shi X, Shi Y, Sidoli S, Smith LM, Tyler JK, Wolberger C, Workman JL, Strahl BD, Young NL

Mol Cell. 85(19):3554-3561. doi: 10.1016/j.molcel.2025.08.029

Publication date: October 4, 2025

PMID: 41043390

Discovery and Characterization of Cell-Permeable Inhibitors of Leishmania mexicana CLK1 Using an In-Cell Target Engagement Assay.

Catta-Preta CMC, Ramos PZ, Carnielli JBT, Vasconcelos SNS, Dowle A, Fanti RC, Dos Reis CV, Coelho AC, Massirer KB, Mottram JC, Couñago RM

ACS Infect Dis. doi: 10.1021/acsinfecdis.5c00610

Publication date: September 25, 2025

PMID: 40994280

Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors.

Fraser BJ, Young NJ, Bender BJ, Gahbauer S, Ilyassov O, Wilson RP, Li Y, Seitova A, Lourenço AL, Chung DH, Bardine C, Bénard F, Shoichet BK, Craik CS, Arrowsmith CH

J Med Chem. doi: 10.1021/acs.jmedchem.4c03089

Publication date: September 20, 2025

PMID: 40973081

Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding.

Anacleto J, Ackloo S, Arrowsmith C, Wolf E, Leblanc Y, Lento C, Wilson DJ

J Am Soc Mass Spectrom. doi: 10.1021/jasms.5c00229

Publication date: September 15, 2025

PMID: 40952355

Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit.

Hoffmann L, Lenz C, Farges F, Kimani SW, Dopfer J, Keller S, Schwalm MP, Holzmann H, Kraemer A, Dong A, Li F, Chau I, Halabelian L, Gstaiger M, Müller S, Knapp S, Němec V

RSC Chem Biol. doi: 10.1039/d5cb00109a

Publication date: September 10, 2025

PMID: 40927425

A soft-stiff patterned bioengineering model reveals kinase pathways driving directional cell migration in pulmonary arterial hypertension.

Islam T, Hooper J, Zhang X, Garcia C, Hasan MM, Drewry DH, Hossain MA, Al-Hilal TA

Biomater Sci. doi: 10.1039/d5bm00224a

Publication date: September 4, 2025

PMID: 40904251

Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID.

Shrestha S, Maitland MER, Jing L, Duan S, Nie DY, St-Germain J, Kanaris M, Barsyte-Lovejoy D, Arrowsmith CH, Raught B

Nat Commun. 16(1):8089. doi: 10.1038/s41467-025-63357-7

Publication date: August 31, 2025

PMID: 40883309

Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1.

Mensing TE, Kurz CG, Amrhein JA, Ehret TAL, Preuss F, Mathea S, Karim M, Tran DHN, Kadlecova Z, Tolvanen TA, Martinez-Molina D, Müller S, Einav S, Knapp S, Hanke T

Eur J Med Chem. 299:118076. doi: 10.1016/j.ejmech.2025.118076

Publication date: August 30, 2025

PMID: 40882436

k-Nearest Neighbor Adaptive Sampling, a Simple Tool to Efficiently Explore Conformational Space.

Rovers E, Thudi A, Hénin J, Maddison CJ, Schapira M

J Chem Theory Comput. doi: 10.1021/acs.jctc.5c00462

Publication date: August 21, 2025

PMID: 40839780

Chemical proteomics reveals human liver fatty acid binding protein as a predominant and selective target of triphenyl phosphate.

Miller J, Han J, Yang D, Diamond ML, Liu R, Peng H

Environ Sci Process Impacts. doi: 10.1039/d5em00327j

Publication date: August 20, 2025

PMID: 40833013

Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design.

Zhubi R, Chaikuad A, Muñoz Sosa CJ, Joerger AC, Knapp S

J Struct Biol X. 12:100134. doi: 10.1016/j.yjsbx.2025.100134

Publication date: August 18, 2025

PMID: 40821731

NUAK kinases: signaling mechanisms and therapeutic applications.

Cullen NM, Rosston P, Tufail B, D'Armond AE, Patel A, Khosravi DH, Burow BC, Hoang VT, Martin EC, Drewry DH, Burow ME, Alahari SK

J Biol Chem. 110565. doi: 10.1016/j.jbc.2025.110565

Publication date: August 8, 2025

PMID: 40774384

A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2.

Hillebrand L, Wang G, Rasch A, Masberg B, Chaikuad A, Kronenberger T, Günther E, Forster M, Poso A, Lämmerhofer M, Laufer SA, Knapp S, Gehringer M

RSC Med Chem. doi: 10.1039/d5md00440c

Publication date: August 4, 2025

PMID: 40756524

Protein-ligand data at scale to support machine learning.

Edwards AM, Owen DR

Nat Rev Chem. doi: 10.1038/s41570-025-00737-z

Publication date: July 24, 2025

PMID: 40702244

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

Kimani SW, Noureldin M, Wilson B, Hoffer L, Green SR, Szewczyk MM, González-Álvarez H, Mohammed M, Chan M, Krausser C, Li ASM, Hajian T, Tucker S, Joshi D, Saraon P, Thériault B, Kim JS, Santhakumar V, Loppnau P, Li Y, Seitova A, Dong A, Kiyota T, Hammann T, Gehrtz P, Patel B, Rathod V, Vala A, Rout B, Jagodra P, Brown PJ, Aman A, Ramnauth J, Poda G, Uehling D, Arrowsmith CH, Barsyte-Lovejoy D, Marcellus R, Ackloo S, Mamai A, Al-Awar R, Halabelian L

Commun Biol. 8(1):1076. doi: 10.1038/s42003-025-08491-0

Publication date: July 20, 2025

PMID: 40683980

Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity.

Muthu Ramalingam B, Oh HJ, Sears JD, Chen CH, Vala A, Liu S, Talbot KM, Hossain MA, Brown PJ, Houliston S, Garcia Perez J, Li F, Amare MG, Halfmann P, Smith JL, Hirsch AJ, Arrowsmith CH, Halabelian L, Vargason A, Couñago RM, Arnold JJ, Cameron CE, Moorman NJ, Heise MT, Willson TM

ACS Infect Dis. doi: 10.1021/acsinfecdis.5c00351

Publication date: July 18, 2025

PMID: 40680191

Exploring the Ligandability of 53BP1 through Fragment-Based Approaches.

Chiew B, Gunzburg MJ, Foley CA, Zeng H, Dong A, Brown PJ, The J, Norris-Drouin JL, Cholensky SH, Mohanty B, Scanlon MJ, Headey SJ, Doak BC, James LI

ACS Med Chem Lett. 16(7):1290-1298. doi: 10.1021/acsmedchemlett.5c00125

Publication date: July 16, 2025

PMID: 40666473

The use of machine learning models to predict progression-free survival and overall survival outcomes from waterfall plots in randomized clinical trials (MAP-OUTCOMES).

Alshankati K, Alshibany A, Toma A, Lajkosz K, Haibe-Kains B, Siu LL

ESMO Open. 10(8):105509. doi: 10.1016/j.esmoop.2025.105509

Publication date: July 16, 2025

PMID: 40664145

A guide to selecting high-performing antibodies for Stearoyl-CoA desaturase (SCD1) (UniProt ID: O00767) for use in western blot, immunoprecipitation, and immunofluorescence.

Ruíz Moleón V, Alende C, Fotouhi M, González Bolívar S, Ayoubi R, Laflamme C

F1000Res. 14:10. doi: 10.12688/f1000research.160217.2

Publication date: July 14, 2025

PMID: 40657179

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity.

Muthu Ramalingam B, Sears JD, Talbot KM, Su YN, Houliston S, Hossain MA, Davis-Gilbert ZW, Zhao C, Oh HJ, Brown PJ, Sanders MK, Moorman SR, Ojha D, Burdick JE, Law I, Morales NL, Martinez SA, Loppnau P, Garcia Perez J, Drobish AM, Morrison TE, Streblow ZJ, Streblow DN, Arrowsmith CH, Vargason A, Couñago RM, Halabelian L, Arnold JJ, Cameron CE, Moorman NJ, Heise MT, Willson TM

J Med Chem. doi: 10.1021/acs.jmedchem.5c00635

Publication date: July 10, 2025

PMID: 40634283

Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.

Fiesel F, Bustillos B, Watzlawik J, Chen C, Berryer M, Zhang J, Boneski P, Hayes C, Bredenberg J, Deneault E, You Z, Abdien N, Aprahamian N, Goldsmith T, Baninameh Z, Cocker L, Zhang H, Goldberg M, Fon E, Trempe JF, Virdee S, Durcan T, Springer W

Autophagy. doi: 10.1080/15548627.2025.2531025

Publication date: July 8, 2025

PMID: 40624741

Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor.

Mandel S, Hanke T, Prendiville N, Baena-Nuevo M, Berger LM, Farges F, Schwalm MP, Berger BT, Kraemer A, Elson L, Saraswati H, Abdul Azeez KR, Dederer V, Mathea S, Corrionero A, Alfonso P, Keller S, Gstaiger M, Krause DS, Müller S, Röhm S, Knapp S

J Med Chem. doi: 10.1021/acs.jmedchem.5c01204

Publication date: July 2, 2025

PMID: 40598933

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Herasymenko O, Silva M, Abu-Saleh AAA, Ahmad A, Alvarado-Huayhuaz J, Arce OEA, Armstrong RJ, Arrowsmith C, Bachta KE, Beck H, Berta D, Bieniek MK, Blay V, Bolotokova A, Bourne PE, Breznik M, Brown PJ, Campbell ADG, Carosati E, Chau I, Cole DJ, Cree B, Dehaen W, Denzinger K, Dos Santos Machado K, Dunn I, Durai P, Edfeldt K, Edwards A, Fayne D, Felfoldi D, Friston K, Ghiabi P, Gibson E, Günther J, Gunnarsson A, Hillisch A, Houston DR, Jensen JH, Harding RJ, Harris KS, Hoffer L, Hogner A, Horton JT, Houliston S, Hultquist JF, Hutchinson A, Irwin JJ, Jukič M, Kandwal S, Karlova A, Katis VL, Kich RP, Kireev D, Koes D, Inniss NL, Lessel U, Liu S, Loppnau P, Lu W, Martino S, McGibbon M, Meiler J, Mettu A, Money-Kyrle S, Moretti R, Moroz YS, Muvva C, Newman JA, Obendorf L, Paige B, Pandit A, Park K, Perveen S, Pirie R, Poda G, Protopopov M, Pütter V, Ricci F, Roper NJ, Rosta E, Rzhetskaya M, Sabnis Y, Satchell KJF, Schmitt Kremer F, Scott T, Seitova A, Steinmann C, Talagayev V, Tarkhanova OO, Tatum NJ, Treleaven D, Velasque Werhli A, Walters WP, Wang X, Wells J, Wells G, Westermaier Y, Wolber G, Wortmann L, Zhang J, Zhao Z, Zheng S, Schapira M

J Chem Inf Model. doi: 10.1021/acs.jcim.5c00535

Publication date: June 20, 2025

PMID: 40539604

A guide to selecting high-performing antibodies for Rab10 (UniProt ID: P61026) for use in western blot, immunoprecipitation, and immunofluorescence.

Ruíz Moleón V, Alende C, Fotouhi M, Southern K, Ayoubi R, Laflamme C

F1000Res. 13:1061. doi: 10.12688/f1000research.156209.1

Publication date: June 19, 2025

PMID: 40535172

A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence.

Ruíz Moleón V, Alende C, Fotouhi M, Ayoubi R, Southern K, Laflamme C

F1000Res. 13:1049. doi: 10.12688/f1000research.155929.2

Publication date: June 19, 2025

PMID: 40535171

Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.

Schönfeld J, Brunst S, Ciomirtan L, Willmer L, Chromik MA, Kumar A, Froemel T, Liebisch N, Hackspacher A, Ehrler JHM, Wintermeier L, Hesse C, Fiedler J, Heering J, Freitag H, Zardo P, Fieguth HG, Brüggerhoff A, Jakob J, Häupl B, Weizel L, Kaiser A, Schubert-Zsilavecz M, Oellerich T, Fleming I, Schebb NH, Fürst R, Kannt A, Knapp S, Proschak E, Hiesinger K

J Med Chem. doi: 10.1021/acs.jmedchem.5c00552

Publication date: June 18, 2025

PMID: 40532036

Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain.

Kim Y, Lučić A, Lenz C, Farges F, Schwalm MP, Saxena K, Hanke T, Marples PG, Aschenbrenner JC, Fearon D, von Delft F, Krämer A, Knapp S

Commun Chem. 8(1):185. doi: 10.1038/s42004-025-01574-3

Publication date: June 14, 2025

PMID: 40514378

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling.

Fan X, Li X, Li T, Shao B, Niu S, Fan W, Wang Q, Zhong L, Wang X, Wang Z, Ma F, Zheng G, Peng H, Chen L, Dong Z

Environ Int. 201:109591. doi: 10.1016/j.envint.2025.109591

Publication date: June 11, 2025

PMID: 40494107

Type II kinase inhibitors that target Parkinson's disease-associated LRRK2.

Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Krämer A, Schwalm MP, Lattal NM, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S

Sci Adv. 11(23):eadt2050. doi: 10.1126/sciadv.adt2050

Publication date: June 4, 2025

PMID: 40465731

Semiquantitative Nontargeted Screening of Organophosphorus Plastic Additives in Consumer Products Using (31)P NMR.

Chen W, Miller JM, Burns DC, Almuhtaram H, Andrews RC, Peng H

Environ Sci Technol. 59(23):11842-11852. doi: 10.1021/acs.est.5c02789

Publication date: June 2, 2025

PMID: 40455101

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Gusev F, Gutkin E, Gentile F, Ban F, Koby SB, Li F, Chau I, Ackloo S, Arrowsmith CH, Bolotokova A, Ghiabi P, Gibson E, Halabelian L, Houliston S, Harding RJ, Hutchinson A, Loppnau P, Perveen S, Seitova A, Zeng H, Schapira M, Cherkasov A, Isayev O, Kurnikova MG

J Chem Inf Model. doi: 10.1021/acs.jcim.5c00588

Publication date: May 26, 2025

PMID: 40415386

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

Aparnathi MK, Ul Haq S, St-Germain J, Nixon KCJ, Walton J, Song L, Majeed S, Patel PS, Subramaniam R, Philip V, Marcellus R, Barsyte-Lovejoy D, Al-Awar R, Hakem R, Arrowsmith CH, Ailles L, Raught B, Lok BH

Neoplasia. 66:101176. doi: 10.1016/j.neo.2025.101176

Publication date: May 26, 2025

PMID: 40413955

Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity.

Hossain MA, Mayo AK, Ghoshal A, Taft-Benz S, Anderson E, Morales NL, Pressey KD, Vargason A, Brouwer KLR, Moorman NJ, Heise MT, Willson TM

J Med Chem. doi: 10.1021/acs.jmedchem.5c00825

Publication date: May 12, 2025

PMID: 40351160

Structural basis of TMPRSS11D specificity and autocleavage activation.

Fraser BJ, Wilson RP, Ferková S, Ilyassov O, Lac J, Dong A, Li YY, Seitova A, Li Y, Hejazi Z, Kenney TMG, Penn LZ, Edwards A, Leduc R, Boudreault PL, Morin GB, Bénard F, Arrowsmith CH

Nat Commun. 16(1):4351. doi: 10.1038/s41467-025-59677-3

Publication date: May 11, 2025

PMID: 40348740

Biochemical investigation of LC3/GABARAP-ligand interaction as an important quality measure for LC3/GABARAP-targeting small molecules: addendum to the guidelines (4th edition).

Schwalm MP, Lenz C, Saxena K, Klionsky DJ, Proschak E, Knapp S

Autophagy. 1-5. doi: 10.1080/15548627.2025.2498506

Publication date: May 9, 2025

PMID: 40344429

Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries.

Dreizler JK, Meyners C, Sugiarto WO, Repity ML, Maciel EVS, Purder PL, Lermyte F, Knapp S, Hausch F

J Med Chem. 68(9):9525-9536. doi: 10.1021/acs.jmedchem.5c00220

Publication date: May 8, 2025

PMID: 40336336

Native Taylor/Non-Taylor Dispersion-Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening.

Eisert J, Maciel EVS, Dederer V, Berwanger A, Bailey HJ, Đikić I, Knapp S, Empting M, Mathea S, Jensen H, Lermyte F

Small Methods. e2500658. doi: 10.1002/smtd.202500658

Publication date: May 7, 2025

PMID: 40331427

Native Flow-Induced Dispersion Analysis - Mass Spectrometry Enables Automated, Multiplexed Ligand Screening from Conventional, Nonvolatile Buffers.

Maciel EVS, Eisert J, Dederer V, Berwanger A, Knapp S, Empting M, Mathea S, Jensen H, Lermyte F

Anal Chem. doi: 10.1021/acs.analchem.5c00696

Publication date: May 5, 2025

PMID: 40324204

Chemical arsenal for helicase Hunters: Striking the toughest targets in antiviral research.

Martin HJ, Hossain MA, Wellnitz J, Kelestemur E, Hochuli JE, Perveen S, Arrowsmith C, Willson TM, Muratov EN, Tropsha A

Antiviral Res. 239:106184. doi: 10.1016/j.antiviral.2025.106184

Publication date: May 3, 2025

PMID: 40316178

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.

Yadav M, AlQazzaz MA, Ciamponi FE, Ho JC, Maron MI, Sababi AM, MacLeod G, Ahmadi M, Bullivant G, Tano V, Langley SR, Sánchez-Osuna M, Sachamitr P, Kushida M, Bardile CF, Pouladi MA, Kurtz R, Richards L, Pugh T, Tyers M, Angers S, Dirks PB, Bader GD, Truant R, Massirer KB, Barsyte-Lovejoy D, Shechter D, Harding RJ, Arrowsmith CH, Prinos P

Nucleic Acids Res. 53(8):. doi: 10.1093/nar/gkaf347

Publication date: April 30, 2025

PMID: 40304179