Publications

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Displaying 2101 - 2150 of 2244

2007

January 2007

Erratum: Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity (Biochemical Journal (2007) 402, (419-427))
Lukacik, P; Keller, B; Bunkoczi, G; Kavanagh, KL; Lee, WH; Adamski, J; Oppermann, U;
Biochemical Journal 403:615- . doi:
Publication date: January 1, 2007
PMID:
Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
Dunford, JE; Kavanagh, KL; Rogers, MJ; Oppermann, U; Ebetin, FH; Russell, G;
Calcified Tissue International 80:S41-S42 . doi:
Publication date: January 1, 2007
PMID:
High-level bacterial expression and purification of apicomplexan micronemal proteins for structural studies.
Saouros, S; Blumenschein, TMA; Sawmynaden, K; Marchant, J; Koutroukides, T; Liu, B; Simpson, P; Carpenter, EP; Matthews, SJ;
Protein and Peptide Letters 14:411-415 . doi:
Publication date: January 1, 2007
PMID: 17584164
The cell-binding region of Toxoplasma gondii micronemal protein 1 presents a novel fold
Blumenschein, TMA; Carpenter, EP; Saciuros, S; Friedrich, N; Koutroukides, T; Soldati, D; Matthews, S;
Biophysical Journal :43A-43A . doi:
Publication date: January 1, 2007
PMID:
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.
Facer, P; Casula, MA; Smith, GD; Benham, CD; Chessell, IP; Bountra, C; Sinisi, M; Birch, R; Anand, P;
BMC Neurology 7:11- . doi: 10.1186/1471-2377-7-11
Publication date: January 1, 2007
PMID: 17521436
Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts.
Atherton, DD; Facer, P; Roberts, KM; Misra, VP; Chizh, BA; Bountra, C; Anand, P;
BMC Neurology 7:21- . doi: 10.1186/1471-2377-7-21
Publication date: January 1, 2007
PMID: 17683543
Molecular replacement
Murshudov, G; Von Delft, F; Ballard, C;
Acta Crystallographica Section D: Biological Crystallography 64:- . doi: 10.1107/S0907444907058714
Publication date: January 1, 2007
PMID: 18376450
Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.
Sitia, G; Iannacone, M; Müller, S; Bianchi, ME; Guidotti, LG;
Journal of Leukocyte Biology 81:100-107 . doi: 10.1189/jlb.0306173
Publication date: January 1, 2007
PMID: 16935945
2006

December 2006

Resonance assignment of the RGS domain of human RGS10.
Fedorov OY, Higman VA, Schmieder P, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ
J. Biomol. NMR 38(2):191 . doi: 10.1007/s10858-006-9111-0
Publication date: December 19, 2006
PMID: 17180548
Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).
Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S
J. Biol. Chem. 281(49):38061-70 . doi: 10.1074/jbc.M606704200
Publication date: December 8, 2006
PMID: 17035239
NMR assignment of human RGS18.
Higman, VA; Leidert, M; Diehl, A; Elkins, J; Soundararajan, M; Oschkinat, H; Ball, LJ;
Journal of Biomolecular NMR 36 Suppl 1:72- . doi: 10.1007/s10858-006-9061-6
Publication date: December 1, 2006
PMID: 16964532

November 2006

Structural basis for protein-protein interactions in the 14-3-3 protein family.
Yang, X; Lee, WH; Sobott, F; Papagrigoriou, E; Robinson, CV; Grossmann, JG; Sundström, M; Doyle, DA; Elkins, JM;
Proceedings of the National Academy of Sciences 103:17237-17242 . doi: 10.1073/pnas.0605779103
Publication date: November 14, 2006
PMID: 17085597
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R
Mol. Biochem. Parasitol. 151(1):100-10 . doi: 10.1016/j.molbiopara.2006.10.011
Publication date: November 13, 2006
PMID: 17125854
Screening for ligands using a generic and high-throughput light-scattering-based assay.
Senisterra GA, Markin E, Yamazaki K, Hui R, Vedadi M, Awrey DE
J Biomol Screen 11(8):940-8 . doi: 10.1177/1087057106294699
Publication date: November 7, 2006
PMID: 17092916
Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Littler DR, Walker JR, She YM, Finerty PJ, Newman EM, Dhe-Paganon S
Biochem. Biophys. Res. Commun. 349(4):1182-9 . doi: 10.1016/j.bbrc.2006.08.160
Publication date: November 3, 2006
PMID: 16973127
Changes in sodium channel expression following trigeminal nerve injury.
Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM;
Experimental Neurology 202:207-216 . doi: 10.1016/j.expneurol.2006.05.035
Publication date: November 1, 2006
PMID: 16908020

October 2006

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM
Proc. Natl. Acad. Sci. U.S.A. 103(43):15835-40 . doi: 10.1073/pnas.0605224103
Publication date: October 24, 2006
PMID: 17035505
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.
Hardcastle, IR; Ahmed, SU; Atkins, H; Farnie, G; Golding, BT; Griffin, RJ; Guyenne, S; Hutton, C; Källblad, P; Kemp, SJ; Kitching, MS; Newell, DR; Norbedo, S; Northen, JS; Reid, RJ; Saravanan, K; Willems, HMG; Lunec, J;
Journal of Medicinal Chemistry 49:6209-6221 . doi: 10.1021/jm0601194
Publication date: October 18, 2006
PMID: 17034127
Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
Oppermann U
Endocr Metab Immune Disord Drug Targets 6(3):259-69 . doi:
Publication date: October 5, 2006
PMID: 17017977

September 2006

Pharmacological FMRI in the development of new analgesic compounds.
Schweinhardt, P; Bountra, C; Tracey, I;
NMR in Biomedicine 19:702-711 . doi: 10.1002/nbm.1076
Publication date: September 30, 2006
PMID: 16986120
Structural basis for molecular recognition and presentation of histone H3 by WDR5.
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J
EMBO J. 25(18):4245-52 . doi: 10.1038/sj.emboj.7601316
Publication date: September 20, 2006
PMID: 16946699
Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).
Dombrovski L, Dong A, Bochkarev A, Plotnikov AN
Proteins 64(4):1091-4 . doi: 10.1002/prot.21048
Publication date: September 1, 2006
PMID: 16804942
Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
Oppermann U.
Endocrine, metabolic & immune disorders drug targets 6(3):259-269 . doi: http://www.eurekaselect.com/77053/article
Publication date: September 1, 2006
PMID: 17017977
Development of an automated large-scale protein-crystallization and monitoring system for high-throughput protein-structure analyses.
Hiraki M, Kato R, Nagai M, Satoh T, Hirano S, Ihara K, Kudo N, Nagae M, Kobayashi M, Inoue M, Uejima T, Oda S, Chavas LM, Akutsu M, Yamada Y, Kawasaki M, Matsugaki N, Igarashi N, Suzuki M, Wakatsuki S.
Acta Crystallogr D Biol Crystallogr 62(Pt 9):1058-65 . doi: 10.1107/S0907444906023821
Publication date: September 1, 2006
PMID: 16929107

August 2006

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
Dunford, JE; Kavanagh, K; Oppermann, U; Ebetino, EH; Russell, RGG; Rogers, MJ;
Journal of Bone and Mineral Research 21:S396-S397 . doi:
Publication date: August 31, 2006
PMID:
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Barr AJ, Knapp S
Trends Pharmacol. Sci. 27(10):525-30 . doi: 10.1016/j.tips.2006.08.005
Publication date: August 21, 2006
PMID: 16919785
Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions (vol 101, pg 11605, 2004)
Amit, R; Gileadi, O; Stavans, J;
Proceedings of the National Academy of Sciences 103:12654-12654 . doi:
Publication date: August 14, 2006
PMID:
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.
Kavanagh KL, Dunford JE, Bunkoczi G, Russell RG, Oppermann U
J. Biol. Chem. 281(31):22004-12 . doi: 10.1074/jbc.M602603200
Publication date: August 4, 2006
PMID: 16698791

July 2006

An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
Wilson, AW; Medhurst, SJ; Dixon, CI; Bontoft, NC; Winyard, LA; Brackenborough, KT; De Alba, J; Clarke, CJ; Gunthorpe, MJ; Hicks, GA; Bountra, C; McQueen, DS; Chessell, IP;
European Journal of Pain 10:537-549 . doi: 10.1016/j.ejpain.2005.08.003
Publication date: July 31, 2006
PMID: 16199187
An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients.
Schweinhardt, P; Glynn, C; Brooks, J; McQuay, H; Jack, T; Chessell, I; Bountra, C; Tracey, I;
NeuroImage 32:256-265 . doi: 10.1016/j.neuroimage.2006.03.024
Publication date: July 31, 2006
PMID: 16679031
High-throughput structural characterisation of therapeutic protein targets.
Marsden BD, Sundstrom M, Knapp S
Expert Opin Drug Discov 1(2):123-36 . doi: 10.1517/17460441.1.2.123
Publication date: July 1, 2006
PMID: 23495796
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset JY, Dalvit C, Knapp S, Fasolini M, Veronesi M, Mantegani S, Gianellini LM, Catana C, Sundström M, Stouten PF, Moll JK
Proteins 64(1):60-7 . doi: 10.1002/prot.20955
Publication date: July 1, 2006
PMID: 16568448

June 2006

Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
Barr AJ, Debreczeni JE, Eswaran J, Knapp S
Proteins 63(4):1132-6 . doi: 10.1002/prot.20958
Publication date: June 1, 2006
PMID: 16534812
Normal NK cell development in absence of Aire.
Lundgren EK, Rosmaraki E, Berg L, Hoglund P, Winqvist O
Journal of Immunology 176; S280-S280 . doi:
Publication date: June 1, 2006
PMID:
NK cells in autoimmune disease
Johansson S, Hall H, Berg L, Hoglund P.
Immunobiology of Natural Killer Cell Receptors 298; 259-77 . doi:
Publication date: June 1, 2006
PMID:

May 2006

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Bullock AN, Debreczeni JE, Edwards AM, Sundström M, Knapp S
Proc. Natl. Acad. Sci. U.S.A. 103(20):7637-42 . doi: 10.1073/pnas.0601638103
Publication date: May 16, 2006
PMID: 16675548
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U
Proc. Natl. Acad. Sci. U.S.A. 103(20):7829-34 . doi: 10.1073/pnas.0601643103
Publication date: May 16, 2006
PMID: 16684881
The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons.
Anand, U; Otto, WR; Casula, MA; Day, NC; Davis, JB; Bountra, C; Birch, R; Anand, P;
Neuroscience Letters 399:51-56 . doi: 10.1016/j.neulet.2006.01.046
Publication date: May 14, 2006
PMID: 16481104
Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination.
Griffin, RJ; Henderson, A; Curtin, NJ; Echalier, A; Endicott, JA; Hardcastle, IR; Newell, DR; Noble, MEM; Wang, L-Z; Golding, BT;
Journal of the American Chemical Society 128:6012-6013 . doi: 10.1021/ja060595j
Publication date: May 9, 2006
PMID: 16669651
The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Eswaran J, Debreczeni JE, Longman E, Barr AJ, Knapp S
Protein Sci. 15(6):1500-5 . doi: 10.1110/ps.062128706
Publication date: May 2, 2006
PMID: 16672235
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ
Biochem. J. 395(3):483-91 . doi: 10.1042/BJ20051931
Publication date: May 1, 2006
PMID: 16441242
Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer.
Williams JP, Smith DC, Green BN, Marsden BD, Jennings KR, Roberts LM, Scrivens JH
Biophys. J. 90(9):3246-54 . doi: 10.1529/biophysj.105.076455
Publication date: May 1, 2006
PMID: 16461395

April 2006

Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer
Williams, JP; Smith, DC; Green, BN; Marsden, BD; Jennings, KR; Roberts, LM; Scrivens, JH;
Biophysical Journal 90:3246-3254 . doi: 10.1529/biophysj.105.076455
Publication date: April 30, 2006
PMID: 16461395
Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.
Shafqat, N; Shafqat, J; Eissner, G; Marschall, H-U; Tryggvason, K; Eriksson, U; Gabrielli, F; Lardy, H; Jörnvall, H; Oppermann, U;
Cellular and Molecular Life Sciences 63:1205-1213 . doi: 10.1007/s00018-006-6013-y
Publication date: April 30, 2006
PMID: 16685466
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.
Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U
J. Biol. Chem. 281(15):10291-7 . doi: 10.1074/jbc.M511346200
Publication date: April 14, 2006
PMID: 16380372

March 2006

Structure and mechanism in the bacterial dihaem cytochrome c peroxidases.
Pettigrew, GW; Echalier, A; Pauleta, SR;
Journal of Inorganic Biochemistry 100:551-567 . doi: 10.1016/j.jinorgbio.2005.12.008
Publication date: March 31, 2006
PMID: 16434100
Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
Hult M, Shafqat N, Elleby B, Mitschke D, Svensson S, Forsgren M, Barf T, Vallgårda J, Abrahmsen L, Oppermann U
Mol. Cell. Endocrinol. 248(1-2):26-33 . doi: 10.1016/j.mce.2005.11.043
Publication date: March 27, 2006
PMID: 16431016
Structure and function of human 17beta-hydroxysteroid dehydrogenases.
Lukacik P, Kavanagh KL, Oppermann U
Mol. Cell. Endocrinol. 248(1-2):61-71 . doi: 10.1016/j.mce.2005.12.007
Publication date: March 27, 2006
PMID: 16414178
Molecular recognition of p53 and MDM2 by USP7/HAUSP
Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.
Nat Struct Mol Biol. 13(3):285-91 . doi:
Publication date: March 15, 2006
PMID: 16474402

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