DARPins as a novel tool to detect and degrade p73.

Read more about DARPins as a novel tool to detect and degrade p73.

Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex.

Read more about Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex.

Probing the Protein Kinases' Cysteinome by Covalent Fragments.

Read more about Probing the Protein Kinases' Cysteinome by Covalent Fragments.

Targeting Na(v)1.7 and Na(v)1.8 with a PIKfyve inhibitor to reverse inflammatory and neuropathic pain.

Read more about Targeting Na(v)1.7 and Na(v)1.8 with a PIKfyve inhibitor to reverse inflammatory and neuropathic pain.

Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.

Read more about Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.

Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors.

Read more about Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors.

17.12.2024

Celebrating Excellence: How SGC Trainees Drive Innovation in Drug Discovery

by: SGC

Photo left to right: Johannes Dopfer (SGC-Frankfurt) and Jacob Capener (SGC-UNC).

16.12.2024

The Future Impact of Machine Learning on Drug Discovery

by: SGC

Originally published on UCL Faculty of Life Sciences website.

Protein: KMT5B

PDB ID: 8T68

Deposition Date: Thursday 15th June 2023

Authors: Zeng, H., Dong, A., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L.

Protein: PRMT9

PDB ID: 9AY9

Deposition Date: Thursday 7th March 2024

Authors: Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Li, Y., Gao, Y.D., Schneider, S., Siliphaivanh, P., Sloman, D., Nicholson, B., Fischer, C., Hicks, J., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L.