DARPin-induced reactivation of p53 in HPV-positive cells. Read more about DARPin-induced reactivation of p53 in HPV-positive cells.
Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. Read more about Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain. Read more about Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling. Read more about Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling.
Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve. Read more about Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve.
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity. Read more about Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity. Read more about A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity.
Probe my Pathway (PmP): a portal to explore the chemical coverage of the human Reactome. Read more about Probe my Pathway (PmP): a portal to explore the chemical coverage of the human Reactome.
Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer. Read more about Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer.
Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example. Read more about Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example.
