MAPK-specific tyrosine phosphatases: new targets for drug discovery? Read more about MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Structural basis for molecular recognition and presentation of histone H3 by WDR5. Read more about Structural basis for molecular recognition and presentation of histone H3 by WDR5.
Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites. Read more about Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology. Read more about Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.
Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases? Read more about Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). Read more about Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Read more about Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. Read more about Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Screening for ligands using a generic and high-throughput light-scattering-based assay. Read more about Screening for ligands using a generic and high-throughput light-scattering-based assay.
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria. Read more about Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.
