Publications | Structural Genomics Consortium

Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kräling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen LO, Meggers E

J. Am. Chem. Soc.. 133(15):5976-86. doi: 10.1021/ja1112996

Publication date: April 20, 2011

PMID: 21446733

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.

Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I

J. Biol. Chem.. 286(15):13261-71. doi: 10.1074/jbc.M110.206771

Publication date: April 15, 2011

PMID: 21257746

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.

Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady RL, Oppermann U, Frayne J, Yue WW

Biochem. J.. 435(2):401-9. doi: 10.1042/BJ20101442

Publication date: April 15, 2011

PMID: 21269272

Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

Salah E, Ugochukwu E, Barr AJ, von Delft F, Knapp S, Elkins JM

J. Med. Chem.. 54(7):2359-67. doi: 10.1021/jm101506n

Publication date: April 14, 2011

PMID: 21417343

Small-molecule ligands of methyl-lysine binding proteins.

Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV

J. Med. Chem.. 54(7):2504-11. doi: 10.1021/jm200045v

Publication date: April 14, 2011

PMID: 21417280

Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects.

Krojer T, von Delft F

J Synchrotron Radiat. 18(Pt 3):387-97. doi: 10.1107/S0909049511008235

Publication date: April 9, 2011

PMID: 21525647

The relationship between the chemistry and biological activity of the bisphosphonates.

Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG

Bone. 49(1):20-33. doi: 10.1016/j.bone.2011.03.774

Publication date: April 9, 2011

PMID: 21497677

Structure and function of WD40 domain proteins.

Xu C, Min J

Protein Cell. 2(3):202-14. doi: 10.1007/s13238-011-1018-1

Publication date: April 6, 2011

PMID: 21468892

The precompetitive space: time to move the yardsticks.

Norman T, Edwards A, Bountra C, Friend S

Sci Transl Med. 3(76):76cm10. doi: 10.1126/scitranslmed.3002399

Publication date: March 30, 2011

PMID: 21451121

Structural basis of fumarate hydratase deficiency.

Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U

J. Inherit. Metab. Dis.. 34(3):671-6. doi: 10.1007/s10545-011-9294-8

Publication date: March 29, 2011

PMID: 21445611

Structural chemistry of the histone methyltransferases cofactor binding site.

Campagna-Slater V, Mok MW, Nguyen KT, Feher M, Najmanovich R, Schapira M

J Chem Inf Model. 51(3):612-23. doi: 10.1021/ci100479z

Publication date: March 28, 2011

PMID: 21366357

The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.

Xu C, Bian C, Lam R, Dong A, Min J

Nat Commun. 2:227. doi: 10.1038/ncomms1237

Publication date: March 17, 2011

PMID: 21407193

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins.

Berridge G, Chalk R, D'Avanzo N, Dong L, Doyle D, Kim JI, Xia X, Burgess-Brown N, Deriso A, Carpenter EP, Gileadi O

Anal. Biochem.. 410(2):272-80. doi: 10.1016/j.ab.2010.11.008

Publication date: March 15, 2011

PMID: 21093405

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.

Liao JC, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, Xiao T, Tempel W, Zuo X, Wang YX, Chirgadze NY, Arrowsmith CH

Structure. 19(3):418-29. doi: 10.1016/j.str.2010.12.015

Publication date: March 9, 2011

PMID: 21397192

A novel ACVR1 mutation in the glycine/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date.

Gregson CL, Hollingworth P, Williams M, Petrie KA, Bullock AN, Brown MA, Tobias JH, Triffitt JT

Bone. 48(3):654-8. doi: 10.1016/j.bone.2010.10.164

Publication date: March 1, 2011

PMID: 21044902

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA

Blood. 117(8):2451-9. doi: 10.1182/blood-2010-11-321208

Publication date: February 24, 2011

PMID: 21190999

High-throughput structural biology of metabolic enzymes and its impact on human diseases.

Yue WW, Oppermann U

J. Inherit. Metab. Dis.. 34(3):575-81. doi: 10.1007/s10545-011-9296-6

Publication date: February 22, 2011

PMID: 21340633

DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.

Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sentürk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, Dötsch V

Cell. 144(4):566-76. doi: 10.1016/j.cell.2011.01.013

Publication date: February 18, 2011

PMID: 21335238

Structural basis for the recognition and cleavage of histone H3 by cathepsin L.

Adams-Cioaba MA, Krupa JC, Xu C, Mort JS, Min J

Nat Commun. 2:197. doi: 10.1038/ncomms1204

Publication date: February 18, 2011

PMID: 21326229

A secretory system for bacterial production of high-profile protein targets.

Kotzsch A, Vernet E, Hammarström M, Berthelsen J, Weigelt J, Gräslund S, Sundström M

Protein Sci.. 20(3):597-609. doi: 10.1002/pro.593

Publication date: February 11, 2011

PMID: 21308845

Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.

Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH

J. Biol. Chem.. 286(6):4796-808. doi: 10.1074/jbc.M110.157669

Publication date: February 11, 2011

PMID: 21084285

Too many roads not taken.

Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH

Nature. 470(7333):163-5. doi: 10.1038/470163a

Publication date: February 10, 2011

PMID: 21307913

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.

Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R

J. Biol. Chem.. 286(5):3315-22. doi: 10.1074/jbc.M109.027235

Publication date: February 4, 2011

PMID: 21084289

DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.

Dhe-Paganon S, Syeda F, Park L

Int J Biochem Mol Biol. 2(1):58-66.

Publication date: January 30, 2011

PMID: 21969122

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, Szklarczyk D, Jensen LJ, Fabbro D, Trappe J, Rauch U, Bracher F, Knapp S

Chem. Biol.. 18(1):67-76. doi: 10.1016/j.chembiol.2010.11.009

Publication date: January 28, 2011

PMID: 21276940

Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.

Newstead S, Drew D, Cameron AD, Postis VL, Xia X, Fowler PW, Ingram JC, Carpenter EP, Sansom MS, McPherson MJ, Baldwin SA, Iwata S

EMBO J.. 30(2):417-26. doi: 10.1038/emboj.2010.309

Publication date: January 19, 2011

PMID: 21131908

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.

Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB

EMBO J.. 30(2):317-27. doi: 10.1038/emboj.2010.311

Publication date: January 19, 2011

PMID: 21119616

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.

Johansson C, Roos AK, Montano SJ, Sengupta R, Filippakopoulos P, Guo K, von Delft F, Holmgren A, Oppermann U, Kavanagh KL

Biochem. J.. 433(2):303-11. doi: 10.1042/BJ20101286

Publication date: January 15, 2011

PMID: 21029046

Animal models of epigenetic regulation in neuropsychiatric disorders.

Bountra C, Oppermann U, Heightman TD

Curr Top Behav Neurosci. 7:281-322. doi: 10.1007/7854_2010_104

Publication date: January 13, 2011

PMID: 21225415

Recognition and specificity determinants of the human cbx chromodomains.

Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH

J. Biol. Chem.. 286(1):521-9. doi: 10.1074/jbc.M110.191411

Publication date: January 7, 2011

PMID: 21047797

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.

Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SS, Rönnstrand L, Knapp S, Bullock AN, Flores-Morales A

J. Biol. Chem.. 286(1):480-90. doi: 10.1074/jbc.M110.173526

Publication date: January 7, 2011

PMID: 21030588

Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders.

Sanger GJ, Chang L, Bountra C, Houghton LA

Therap Adv Gastroenterol. 3(5):291-305. doi: 10.1177/1756283X10369922

Publication date: December 25, 2010

PMID: 21180610

Selective inhibition of BET bromodomains.

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE

Nature. 468(7327):1067-73. doi: 10.1038/nature09504

Publication date: December 23, 2010

PMID: 20871596

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ

Chem. Biol.. 17(12):1316-24. doi: 10.1016/j.chembiol.2010.09.016

Publication date: December 22, 2010

PMID: 21168767

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD

Cell Host Microbe. 8(6):484-95. doi: 10.1016/j.chom.2010.11.005

Publication date: December 16, 2010

PMID: 21147463