Publications | Structural Genomics Consortium

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE

Nature. 468(7327):1067-73. doi: 10.1038/nature09504

Publication date: December 23, 2010

PMID: 20871596

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ

Chem. Biol.. 17(12):1316-24. doi: 10.1016/j.chembiol.2010.09.016

Publication date: December 22, 2010

PMID: 21168767

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD

Cell Host Microbe. 8(6):484-95. doi: 10.1016/j.chom.2010.11.005

Publication date: December 16, 2010

PMID: 21147463

Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.

Turgeon Z, Jørgensen R, Visschedyk D, Edwards PR, Legree S, McGregor C, Fieldhouse RJ, Mangroo D, Schapira M, Merrill AR

Antimicrob. Agents Chemother.. 55(3):983-91. doi: 10.1128/AAC.01164-10

Publication date: December 6, 2010

PMID: 21135177

Structures of parasitic CDPK domains point to a common mechanism of activation.

Wernimont AK, Amani M, Qiu W, Pizarro JC, Artz JD, Lin YH, Lew J, Hutchinson A, Hui R

Proteins. 79(3):803-20. doi: 10.1002/prot.22919

Publication date: December 3, 2010

PMID: 21287613

Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.

Froese DS, Kochan G, Muniz JR, Wu X, Gileadi C, Ugochukwu E, Krysztofinska E, Gravel RA, Oppermann U, Yue WW

J. Biol. Chem.. 285(49):38204-13. doi: 10.1074/jbc.M110.177717

Publication date: December 3, 2010

PMID: 20876572

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.

El Bakkouri M, Pow A, Mulichak A, Cheung KL, Artz JD, Amani M, Fell S, de Koning-Ward TF, Goodman CD, McFadden GI, Ortega J, Hui R, Houry WA

J. Mol. Biol.. 404(3):456-77. doi: 10.1016/j.jmb.2010.09.051

Publication date: December 3, 2010

PMID: 20887733

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.

Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW

Proc. Natl. Acad. Sci. U.S.A.. 107(47):20346-51. doi: 10.1073/pnas.1009008107

Publication date: November 23, 2010

PMID: 21057110

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A

PLoS ONE. 5(11):e15535. doi: 10.1371/journal.pone.0015535

Publication date: November 23, 2010

PMID: 21124847

Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.

Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, Lee W

J. Biol. Chem.. 285(46):36070-80. doi: 10.1074/jbc.M110.145219

Publication date: November 12, 2010

PMID: 20826778

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).

Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J

Proc. Natl. Acad. Sci. U.S.A.. 107(45):19266-71. doi: 10.1073/pnas.1008937107

Publication date: November 9, 2010

PMID: 20974918

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

Lucic B, Zhang Y, King O, Mendoza-Maldonado R, Berti M, Niesen FH, Burgess-Brown NA, Pike AC, Cooper CD, Gileadi O, Vindigni A

Nucleic Acids Res.. 39(5):1703-17. doi: 10.1093/nar/gkq1031

Publication date: November 8, 2010

PMID: 21059676

Regulation and cytoprotective role of hexokinase III.

Wyatt E, Wu R, Rabeh W, Park HW, Ghanefar M, Ardehali H

PLoS ONE. 5(11):e13823. doi: 10.1371/journal.pone.0013823

Publication date: November 3, 2010

PMID: 21072205

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A

PLoS ONE. 5(11):e13719. doi: 10.1371/journal.pone.0013719

Publication date: November 2, 2010

PMID: 21072165

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.

Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J

PLoS ONE. 5(11):e13559. doi: 10.1371/journal.pone.0013559

Publication date: November 2, 2010

PMID: 21072162

Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112.

Keum YS, Lee HR, Park HW, Kim JH

Biodegradation. 21(6):989-97. doi: 10.1007/s10532-010-9358-8

Publication date: November 1, 2010

PMID: 20455075

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.

Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J

Proc. Natl. Acad. Sci. U.S.A.. 107(43):18398-403. doi: 10.1073/pnas.1013106107

Publication date: October 26, 2010

PMID: 20937909

Structural genomics of histone tail recognition.

Wang M, Mok MW, Harper H, Lee WH, Min J, Knapp S, Oppermann U, Marsden B, Schapira M

Bioinformatics. 26(20):2629-30. doi: 10.1093/bioinformatics/btq491

Publication date: October 15, 2010

PMID: 20739309

Arp1, an actin-related protein, in Plasmodium berghei.

Siden-Kiamos I, Schüler H, Liakopoulos D, Louis C

Mol. Biochem. Parasitol.. 173(2):88-96. doi: 10.1016/j.molbiopara.2010.05.008

Publication date: October 1, 2010

PMID: 20580650

Comparative structural analysis of human DEAD-box RNA helicases.

Schütz P, Karlberg T, van den Berg S, Collins R, Lehtiö L, Högbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarström M, Moche M, Thorsell AG, Schüler H

PLoS ONE. 5(9):. doi: 10.1371/journal.pone.0012791

Publication date: September 30, 2010

PMID: 20941364

UDP-glucose dehydrogenase: structure and function of a potential drug target.

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B

Biochem. Soc. Trans.. 38(5):1378-85. doi: 10.1042/BST0381378

Publication date: September 25, 2010

PMID: 20863317

The crystal structure of Toxoplasma gondii pyruvate kinase 1.

Bakszt R, Wernimont A, Allali-Hassani A, Mok MW, Hills T, Hui R, Pizarro JC

PLoS ONE. 5(9):e12736. doi: 10.1371/journal.pone.0012736

Publication date: September 14, 2010

PMID: 20856875

MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.

Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y

Mol. Cell. Biol.. 30(22):5335-47. doi: 10.1128/MCB.00350-10

Publication date: September 13, 2010

PMID: 20837706

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

Porté S, Moeini A, Reche I, Shafqat N, Oppermann U, Farrés J, Parés X

Cell. Mol. Life Sci.. 68(6):1065-77. doi: 10.1007/s00018-010-0508-2

Publication date: September 11, 2010

PMID: 20835842

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C

Anal. Biochem.. 404(1):86-93. doi: 10.1016/j.ab.2010.04.030

Publication date: September 1, 2010

PMID: 20435012

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN

J. Mol. Biol.. 401(3):389-402. doi: 10.1016/j.jmb.2010.06.017

Publication date: August 20, 2010

PMID: 20561531

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.

Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, Ferguson MA

Glycobiology. 20(12):1619-30. doi: 10.1093/glycob/cwq115

Publication date: August 19, 2010

PMID: 20724435

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ

J. Mol. Biol.. 401(2):211-22.

Publication date: August 13, 2010

PMID: 20684070

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J

J. Med. Chem.. 53(15):5844-57. doi: 10.1021/jm100478y

Publication date: August 12, 2010

PMID: 20614940

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH

PLoS ONE. 5(8):e11905. doi: 10.1371/journal.pone.0011905

Publication date: August 6, 2010

PMID: 20730082

A software tool to accelerate design of protein constructs for recombinant expression.

Sagemark J, Kraulis P, Weigelt J

Protein Expr. Purif.. 72(2):175-8. doi: 10.1016/j.pep.2010.03.020

Publication date: August 1, 2010

PMID: 20359538

Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis.

Wigle TJ, Provencher LM, Norris JL, Jin J, Brown PJ, Frye SV, Janzen WP

Chem. Biol.. 17(7):695-704. doi: 10.1016/j.chembiol.2010.04.014

Publication date: July 30, 2010

PMID: 20659682

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S

PLoS Biol.. 8(7):e1000439. doi: 10.1371/journal.pbio.1000439

Publication date: July 27, 2010

PMID: 20676357

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S

PLoS Biol.. 8(7):e1000426. doi: 10.1371/journal.pbio.1000426

Publication date: July 27, 2010

PMID: 20668654

Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.

Schütz P, Wahlberg E, Karlberg T, Hammarström M, Collins R, Flores A, Schüler H

J. Mol. Biol.. 400(4):768-82. doi: 10.1016/j.jmb.2010.05.046

Publication date: July 23, 2010

PMID: 20510246

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.

Karlberg T, Markova N, Johansson I, Hammarström M, Schütz P, Weigelt J, Schüler H

J. Med. Chem.. 53(14):5352-5. doi: 10.1021/jm100249w

Publication date: July 22, 2010

PMID: 20565110

Targeting kinases for the treatment of inflammatory diseases.

Müller S, Knapp S

Expert Opin Drug Discov. 5(9):867-81. doi: 10.1517/17460441.2010.504203

Publication date: July 15, 2010

PMID: 22823261

Quinone oxidoreductase-2-mediated prodrug cancer therapy.

Middleton MR, Knox R, Cattell E, Oppermann U, Midgley R, Ali R, Auton T, Agarwal R, Anderson D, Sarker D, Judson I, Osawa T, Spanswick VJ, Davies S, Hartley JA, Kerr DJ

Sci Transl Med. 2(40):40ra50. doi: 10.1126/scitranslmed.3000615

Publication date: July 14, 2010

PMID: 20630857