Publications

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2010

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.

Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW

Proc. Natl. Acad. Sci. U.S.A.. 107(47):20346-51. doi: 10.1073/pnas.1009008107

Publication date: November 23, 2010

PMID: 21057110

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A

PLoS ONE. 5(11):e15535. doi: 10.1371/journal.pone.0015535

Publication date: November 23, 2010

PMID: 21124847

Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.

Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, Lee W

J. Biol. Chem.. 285(46):36070-80. doi: 10.1074/jbc.M110.145219

Publication date: November 12, 2010

PMID: 20826778

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).

Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J

Proc. Natl. Acad. Sci. U.S.A.. 107(45):19266-71. doi: 10.1073/pnas.1008937107

Publication date: November 9, 2010

PMID: 20974918

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

Lucic B, Zhang Y, King O, Mendoza-Maldonado R, Berti M, Niesen FH, Burgess-Brown NA, Pike AC, Cooper CD, Gileadi O, Vindigni A

Nucleic Acids Res.. 39(5):1703-17. doi: 10.1093/nar/gkq1031

Publication date: November 8, 2010

PMID: 21059676

Regulation and cytoprotective role of hexokinase III.

Wyatt E, Wu R, Rabeh W, Park HW, Ghanefar M, Ardehali H

PLoS ONE. 5(11):e13823. doi: 10.1371/journal.pone.0013823

Publication date: November 3, 2010

PMID: 21072205

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A

PLoS ONE. 5(11):e13719. doi: 10.1371/journal.pone.0013719

Publication date: November 2, 2010

PMID: 21072165

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.

Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J

PLoS ONE. 5(11):e13559. doi: 10.1371/journal.pone.0013559

Publication date: November 2, 2010

PMID: 21072162

Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112.

Keum YS, Lee HR, Park HW, Kim JH

Biodegradation. 21(6):989-97. doi: 10.1007/s10532-010-9358-8

Publication date: November 1, 2010

PMID: 20455075

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.

Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J

Proc. Natl. Acad. Sci. U.S.A.. 107(43):18398-403. doi: 10.1073/pnas.1013106107

Publication date: October 26, 2010

PMID: 20937909

Structural genomics of histone tail recognition.

Wang M, Mok MW, Harper H, Lee WH, Min J, Knapp S, Oppermann U, Marsden B, Schapira M

Bioinformatics. 26(20):2629-30. doi: 10.1093/bioinformatics/btq491

Publication date: October 15, 2010

PMID: 20739309

Arp1, an actin-related protein, in Plasmodium berghei.

Siden-Kiamos I, Schüler H, Liakopoulos D, Louis C

Mol. Biochem. Parasitol.. 173(2):88-96. doi: 10.1016/j.molbiopara.2010.05.008

Publication date: October 1, 2010

PMID: 20580650

Comparative structural analysis of human DEAD-box RNA helicases.

Schütz P, Karlberg T, van den Berg S, Collins R, Lehtiö L, Högbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarström M, Moche M, Thorsell AG, Schüler H

PLoS ONE. 5(9):. doi: 10.1371/journal.pone.0012791

Publication date: September 30, 2010

PMID: 20941364

UDP-glucose dehydrogenase: structure and function of a potential drug target.

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B

Biochem. Soc. Trans.. 38(5):1378-85. doi: 10.1042/BST0381378

Publication date: September 25, 2010

PMID: 20863317

The crystal structure of Toxoplasma gondii pyruvate kinase 1.

Bakszt R, Wernimont A, Allali-Hassani A, Mok MW, Hills T, Hui R, Pizarro JC

PLoS ONE. 5(9):e12736. doi: 10.1371/journal.pone.0012736

Publication date: September 14, 2010

PMID: 20856875

MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.

Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y

Mol. Cell. Biol.. 30(22):5335-47. doi: 10.1128/MCB.00350-10

Publication date: September 13, 2010

PMID: 20837706

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

Porté S, Moeini A, Reche I, Shafqat N, Oppermann U, Farrés J, Parés X

Cell. Mol. Life Sci.. 68(6):1065-77. doi: 10.1007/s00018-010-0508-2

Publication date: September 11, 2010

PMID: 20835842

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C

Anal. Biochem.. 404(1):86-93. doi: 10.1016/j.ab.2010.04.030

Publication date: September 1, 2010

PMID: 20435012

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN

J. Mol. Biol.. 401(3):389-402. doi: 10.1016/j.jmb.2010.06.017

Publication date: August 20, 2010

PMID: 20561531

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.

Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, Ferguson MA

Glycobiology. 20(12):1619-30. doi: 10.1093/glycob/cwq115

Publication date: August 19, 2010

PMID: 20724435

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ

J. Mol. Biol.. 401(2):211-22.

Publication date: August 13, 2010

PMID: 20684070

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J

J. Med. Chem.. 53(15):5844-57. doi: 10.1021/jm100478y

Publication date: August 12, 2010

PMID: 20614940

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH

PLoS ONE. 5(8):e11905. doi: 10.1371/journal.pone.0011905

Publication date: August 6, 2010

PMID: 20730082

A software tool to accelerate design of protein constructs for recombinant expression.

Sagemark J, Kraulis P, Weigelt J

Protein Expr. Purif.. 72(2):175-8. doi: 10.1016/j.pep.2010.03.020

Publication date: August 1, 2010

PMID: 20359538

Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis.

Wigle TJ, Provencher LM, Norris JL, Jin J, Brown PJ, Frye SV, Janzen WP

Chem. Biol.. 17(7):695-704. doi: 10.1016/j.chembiol.2010.04.014

Publication date: July 30, 2010

PMID: 20659682

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S

PLoS Biol.. 8(7):e1000439. doi: 10.1371/journal.pbio.1000439

Publication date: July 27, 2010

PMID: 20676357

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S

PLoS Biol.. 8(7):e1000426. doi: 10.1371/journal.pbio.1000426

Publication date: July 27, 2010

PMID: 20668654

Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.

Schütz P, Wahlberg E, Karlberg T, Hammarström M, Collins R, Flores A, Schüler H

J. Mol. Biol.. 400(4):768-82. doi: 10.1016/j.jmb.2010.05.046

Publication date: July 23, 2010

PMID: 20510246

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.

Karlberg T, Markova N, Johansson I, Hammarström M, Schütz P, Weigelt J, Schüler H

J. Med. Chem.. 53(14):5352-5. doi: 10.1021/jm100249w

Publication date: July 22, 2010

PMID: 20565110

Targeting kinases for the treatment of inflammatory diseases.

Müller S, Knapp S

Expert Opin Drug Discov. 5(9):867-81. doi: 10.1517/17460441.2010.504203

Publication date: July 15, 2010

PMID: 22823261

Quinone oxidoreductase-2-mediated prodrug cancer therapy.

Middleton MR, Knox R, Cattell E, Oppermann U, Midgley R, Ali R, Auton T, Agarwal R, Anderson D, Sarker D, Judson I, Osawa T, Spanswick VJ, Davies S, Hartley JA, Kerr DJ

Sci Transl Med. 2(40):40ra50. doi: 10.1126/scitranslmed.3000615

Publication date: July 14, 2010

PMID: 20630857

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.

Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE

Proc. Natl. Acad. Sci. U.S.A.. 107(28):12593-8. doi: 10.1073/pnas.0909087107

Publication date: July 13, 2010

PMID: 20571119

Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.

Bacik JP, Walker JR, Ali M, Schimmer AD, Dhe-Paganon S

J. Biol. Chem.. 285(26):20273-80. doi: 10.1074/jbc.M110.102921

Publication date: June 25, 2010

PMID: 20368332

Architecture of Eph receptor clusters.

Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S

Proc. Natl. Acad. Sci. U.S.A.. 107(24):10860-5. doi: 10.1073/pnas.1004148107

Publication date: June 15, 2010

PMID: 20505120

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V

J. Biol. Chem.. 285(24):18452-63. doi: 10.1074/jbc.M109.077925

Publication date: June 11, 2010

PMID: 20207735

High-throughput production of human proteins for crystallization: the SGC experience.

Savitsky P, Bray J, Cooper CD, Marsden BD, Mahajan P, Burgess-Brown NA, Gileadi O

J. Struct. Biol.. 172(1):3-13. doi: 10.1016/j.jsb.2010.06.008

Publication date: June 10, 2010

PMID: 20541610

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.

Healy S, McDonald MK, Wu X, Yue WW, Kochan G, Oppermann U, Gravel RA

Biochemistry. 49(22):4687-94. doi: 10.1021/bi901612y

Publication date: June 8, 2010

PMID: 20443544

Mass spectrometry following mild enzymatic digestion reveals phosphorylation of recombinant proteins in Escherichia coli through mechanisms involving direct nucleotide binding.

She YM, Xu X, Yakunin AF, Dhe-Paganon S, Donald LJ, Standing KG, Lee DC, Jia Z, Cyr TD

J. Proteome Res.. 9(6):3311-8. doi: 10.1021/pr9011987

Publication date: June 4, 2010

PMID: 20405931

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ

Bioorg. Med. Chem. Lett.. 20(11):3387-93. doi: 10.1016/j.bmcl.2010.04.015

Publication date: June 1, 2010

PMID: 20451379

Towards proteome scale antibody selections using phage display.

Mersmann M, Meier D, Mersmann J, Helmsing S, Nilsson P, Gräslund S, Colwill K, Hust M, Dübel S

N Biotechnol. 27(2):118-28. doi: 10.1016/j.nbt.2009.10.007

Publication date: May 31, 2010

PMID: 19883803

Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR

J. Biol. Chem.. 285(21):16218-30. doi: 10.1074/jbc.M109.070953

Publication date: May 21, 2010

PMID: 20207729

Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

Hong BS, Allali-Hassani A, Tempel W, Finerty PJ, Mackenzie F, Dimov S, Vedadi M, Park HW

J. Biol. Chem.. 285(21):16330-40. doi: 10.1074/jbc.M109.039024

Publication date: May 21, 2010

PMID: 20299452

Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.

Jörnvall H, Hedlund J, Bergman T, Oppermann U, Persson B

Biochem. Biophys. Res. Commun.. 396(1):125-30. doi: 10.1016/j.bbrc.2010.03.094

Publication date: May 21, 2010

PMID: 20494124

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.

Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD

Nature. 465(7296):359-62. doi: 10.1038/nature09022

Publication date: May 20, 2010

PMID: 20485436

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW

J. Mol. Biol.. 398(4):497-506. doi: 10.1016/j.jmb.2010.03.034

Publication date: May 14, 2010

PMID: 20346956

Biophysical characterization of recombinant proteins: a key to higher structural genomics success.

Vedadi M, Arrowsmith CH, Allali-Hassani A, Senisterra G, Wasney GA

J. Struct. Biol.. 172(1):107-19. doi: 10.1016/j.jsb.2010.05.005

Publication date: May 11, 2010

PMID: 20466062

A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

Quinn AM, Allali-Hassani A, Vedadi M, Simeonov A

Mol Biosyst. 6(5):782-8. doi: 10.1039/b921912a

Publication date: May 10, 2010

PMID: 20567762

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.

Wernimont AK, Artz JD, Finerty P, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R

Nat. Struct. Mol. Biol.. 17(5):596-601. doi: 10.1038/nsmb.1795

Publication date: May 2, 2010

PMID: 20436473

Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite.

Huttu J, Singh BK, Bhargav SP, Sattler JM, Schüler H, Kursula I

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 66(Pt 5):583-7. doi: 10.1107/S1744309110011589

Publication date: May 1, 2010

PMID: 20445265

Structural genomics-impact on biomedicine and drug discovery.

Weigelt J

Exp. Cell Res.. 316(8):1332-8. doi: 10.1016/j.yexcr.2010.02.041

Publication date: May 1, 2010

PMID: 20211166

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