Publications

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Displaying 2001 - 2050 of 2244

2008

February 2008

Redox-linked structural changes associated with the formation of a catalytically competent form of the diheme cytochrome c peroxidase from Pseudomonas aeruginosa.
Echalier, A; Brittain, T; Wright, J; Boycheva, S; Mortuza, GB; Fülöp, V; Watmough, NJ;
Biochemistry 47:1947-1956 . doi: 10.1021/bi702064f
Publication date: February 19, 2008
PMID: 18217775
Bermuda Principles meet structural biology.
Edwards A
Nat. Struct. Mol. Biol. 15(2):116 . doi: 10.1038/nsmb0208-116
Publication date: February 6, 2008
PMID: 18250626
Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
Titanji K, Sammicheli S, De Milito A, Mantegani P, Fortis C, Berg L, Karre K, Travi G, Tassandin C, Lopalco L, Rethi B, Tambussi G, Chiodi F.
Immunolog 123(2):164-70 . doi: 10.1111/j.1365-2567.2007.02657.x
Publication date: February 1, 2008
PMID: 17627773
Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design.
Merckx, A; Echalier, A; Langford, K; Sicard, A; Langsley, G; Joore, J; Doerig, C; Noble, M; Endicott, J;
Structure 16:228-238 . doi: 10.1016/j.str.2007.11.014
Publication date: February 1, 2008
PMID: 18275814
Protein production and purification.
Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A, Vincentelli R, Cambillau C, Kim R, Kim SH, Rao Z, Shi Y, Terwilliger TC, Kim CY, Hung LW, Waldo GS, Peleg Y, Albeck S, Unger T, Dym O, Prilusky J, Sussman JL, Stevens RC, Lesley SA, Wilson IA, Joachimiak A, Collart F, Dementieva I, Donnelly MI, Eschenfeldt WH, Kim Y, Stols L, Wu R, Zhou M, Burley SK, Emtage JS, Sauder JM, Thompson D, Bain K, Luz J, Gheyi T, Zhang F, Atwell S, Almo SC, Bonanno JB, Fiser A, Swaminathan S, Studier FW, Chance MR, Sali A, Acton TB, Xiao R, Zhao L, Ma LC, Hunt JF, Tong L, Cunningham K, Inouye M, Anderson S, Janjua H, Shastry R, Ho CK, Wang D, Wang H, Jiang M, Montelione GT, Stuart DI, Owens RJ, Daenke S, Schütz A, Heinemann U, Yokoyama S, Büssow K, Gunsalus KC
Nat. Methods 5(2):135-46 . doi: 10.1038/nmeth.f.202
Publication date: February 1, 2008
PMID: 18235434
Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS
J. Biol. Chem. 283(5):2835-45 . doi: 10.1074/jbc.M706163200
Publication date: February 1, 2008
PMID: 18056714

January 2008

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.
Burgess-Brown NA, Sharma S, Sobott F, Loenarz C, Oppermann U, Gileadi O
Protein Expr. Purif. 59(1):94-102 . doi: 10.1016/j.pep.2008.01.008
Publication date: January 26, 2008
PMID: 18289875
First crystallographic models of human TBC domains in the context of a family-wide structural analysis.
Tempel W, Tong Y, Dimov S, Bochkarev A, Park H
Proteins 71(1):497-502 . doi: 10.1002/prot.21885
Publication date: January 12, 2008
PMID: 18186464
Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.
Eswaran J, Bernad A, Ligos JM, Guinea B, Debreczeni JE, Sobott F, Parker SA, Najmanovich R, Turk BE, Knapp S
Structure 16(1):115-24 . doi: 10.1016/j.str.2007.10.026
Publication date: January 11, 2008
PMID: 18184589
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.
Ludwig C,Michiels PJ,Wu X,Kavanagh KL,Pilka E,Jansson A,Oppermann U,Gunther UL.
Journal of medicinal chemistry 51(1):1-3 . doi: http://dx.doi.org/10.1021/jm701020f
Publication date: January 10, 2008
PMID: 18062662
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.
Ludwig C, Michiels PJ, Wu X, Kavanagh KL, Pilka E, Jansson A, Oppermann U, Günther UL
J. Med. Chem. 51(1):1-3 . doi: 10.1021/jm701020f
Publication date: January 10, 2008
PMID: 18062662
Baculovirus expression vector system: An emerging host for high-throughput eukaryotic protein expression
Shrestha, B; Smee, C; Gileadi, O;
Methods in Molecular Biology 439:269-289 . doi: 10.1007/978-1-59745-188-8_19
Publication date: January 1, 2008
PMID:
Primary ductal carcinoma in situ mammosphere formation: importance of the epidermal growth factor and Notch receptor signalling pathways.
Farnie, G; Spence, K; Brennan, K; Bundred, NJ; Clarke, RB;
Breast Cancer Research 10:P94-P94 . doi: 10.1186/bcr1978
Publication date: January 1, 2008
PMID:
Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
Dunford, JE; Pilka, E; Kwaasi, AA; Evdokimov, A; Barnett, BL; Oppermann, U; Ebetino, FH; Russell, RG; Kavanagh, KL;
Calcified Tissue International 82:S223-S223 . doi:
Publication date: January 1, 2008
PMID:
Novel approaches to the therapy of rheumatoid arthritis based on an understanding of disease mechanisms
McCann, FE; Williams, RO;
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry 8:275-284 . doi: 10.2174/187152208785748359
Publication date: January 1, 2008
PMID:
Perspectives of Alzheimer's disease treatments.
Davis, JB; Bountra, C; Richardson, J;
Handbook of Clinical Neurology 89:273-290 . doi: 10.1016/S0072-9752(07)01226-2
Publication date: January 1, 2008
PMID: 18631752
Protocol for the induction of arthritis in C57BL/6 mice.
Inglis, JJ; Simelyte, E; McCann, FE; Criado, G; Williams, RO;
Nature Protocols 3:612-618 . doi: 10.1038/nprot.2008.19
Publication date: January 1, 2008
PMID: 18388943
Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.
Howell, SJ; Anderson, E; Hunter, T; Farnie, G; Clarke, RB;
Breast Cancer Research 10:R68- . doi: 10.1186/bcr2129
Publication date: January 1, 2008
PMID: 18681966
Are stem-like cells responsible for resistance to therapy in breast cancer?
O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB;
Breast Disease 29:83-89 . doi:
Publication date: January 1, 2008
PMID: 19029627
2007

December 2007

Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M
J. Biol. Chem. 282(51):37215-24 . doi: 10.1074/jbc.M703800200
Publication date: December 21, 2007
PMID: 17916560
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S
Proc. Natl. Acad. Sci. U.S.A. 104(51):20523-8 . doi: 10.1073/pnas.0708800104
Publication date: December 18, 2007
PMID: 18077363
Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification.
Simeonov A, Yasgar A, Klumpp C, Zheng W, Shafqat N, Oppermann U, Austin CP, Inglese J
Assay Drug Dev Technol 5(6):815-24 . doi: 10.1089/adt.2007.097
Publication date: December 15, 2007
PMID: 18078381
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH
Ann. N. Y. Acad. Sci. 1117:209-57 . doi: 10.1196/annals.1402.089
Publication date: December 7, 2007
PMID: 18056045
In situ proteolysis for protein crystallization and structure determination.
Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H.
Nat Methods 4(12):1019-21 . doi:
Publication date: December 1, 2007
PMID: 17982461

November 2007

The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins.
Gräslund S, Sagemark J, Berglund H, Dahlgren LG, Flores A, Hammarström M, Johansson I, Kotenyova T, Nilsson M, Nordlund P, Weigelt J
Protein Expr. Purif. 58(2):210-21 . doi: 10.1016/j.pep.2007.11.008
Publication date: November 22, 2007
PMID: 18171622
Mechanism and substrate recognition of human holo ACP synthase.
Bunkoczi G, Pasta S, Joshi A, Wu X, Kavanagh KL, Smith S, Oppermann U
Chem. Biol. 14(11):1243-53 . doi: 10.1016/j.chembiol.2007.10.013
Publication date: November 21, 2007
PMID: 18022563
L3MBTL1 recognition of mono- and dimethylated histones.
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH
Nat. Struct. Mol. Biol. 14(12):1229-30 . doi: 10.1038/nsmb1340
Publication date: November 18, 2007
PMID: 18026117
Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S
Structure 15(11):1493-504 . doi: 10.1016/j.str.2007.09.016
Publication date: November 14, 2007
PMID: 17997974
Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.
Hassler, M; Singh, S; Yue, WW; Luczynski, M; Lakbir, R; Sanchez-Sanchez, F; Bader, T; Pearl, LH; Mittnacht, S;
Molecular Cell 28:371-385 . doi: 10.1016/j.molcel.2007.08.023
Publication date: November 9, 2007
PMID: 17996702
Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
Yiangou, Y; Facer, P; Chessell, IP; Bountra, C; Chan, C; Fertleman, C; Smith, V; Anand, P;
Neuroscience Letters 427:77-82 . doi: 10.1016/j.neulet.2007.09.027
Publication date: November 5, 2007
PMID: 17928139
In situ proteolysis for protein crystallization and structure determination.
Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H
Nat. Methods 4(12):1019-21 . doi: 10.1038/nmeth1118
Publication date: November 4, 2007
PMID: 17982461

October 2007

Structure determination of the motor domain of yeast kinesin kar3 by x-ray crystallography.
Park HW
Methods Mol. Biol. 392:199-211 . doi: 10.1007/978-1-59745-490-2_14
Publication date: October 24, 2007
PMID: 17951720
Structural and functional characterization of the human protein kinase ASK1.
Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Müller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S
Structure 15(10):1215-26 . doi: 10.1016/j.str.2007.08.011
Publication date: October 17, 2007
PMID: 17937911
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.
Yue, WW; Hassler, M; Roe, SM; Thompson-Vale, V; Pearl, LH;
EMBO Journal 26:4402-4412 . doi: 10.1038/sj.emboj.7601856
Publication date: October 16, 2007
PMID: 17882261
Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S
J. Mol. Biol. 373(1):167-77 . doi: 10.1016/j.jmb.2007.07.053
Publication date: October 12, 2007
PMID: 17822713
Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.
Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, Grant DM, Plotnikov AN
J. Biol. Chem. 282(41):30189-97 . doi: 10.1074/jbc.M704138200
Publication date: October 12, 2007
PMID: 17656365
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi O, Knapp S, Lee WH, Marsden BD, Müller S, Niesen FH, Kavanagh KL, Ball LJ, von Delft F, Doyle DA, Oppermann UC, Sundström M
J. Struct. Funct. Genomics 8(2-3):107-19 . doi: 10.1007/s10969-007-9027-2
Publication date: October 12, 2007
PMID: 17932789
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C
PLoS Biol. 5(10):e263 . doi: 10.1371/journal.pbio.0050263
Publication date: October 2, 2007
PMID: 17914902
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion
de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K.
Immunology 122(2):291-301 . doi: 10.1111/j.1365-2567.2007.02638.x
Publication date: October 1, 2007
PMID: 17521371

September 2007

Cytotoxic hybrids between the aromatic alkaloids bauerine C and rutaecarpine
Huber, K; Bracher, F;
Zeitschrift fur Naturforschung B 62:1313-1316 . doi:
Publication date: September 30, 2007
PMID:
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW
J. Biol. Chem. 282(38):27984-93 . doi: 10.1074/jbc.M701915200
Publication date: September 21, 2007
PMID: 17631502
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability.
Niesen FH, Berglund H, Vedadi M
Nat Protoc 2(9):2212-21 . doi: 10.1038/nprot.2007.321
Publication date: September 15, 2007
PMID: 17853878
The expression of human natural killer cell receptors in early life
Sundstrom Y, Nilsson C, Lilja G, Karre K, Troye-Blomberg M, Berg L.
Scand J Immunol. 66(2-3):335-44 . doi: 10.1111/j.1365-3083.2007.01980.x
Publication date: September 1, 2007
PMID: 17635811

August 2007

Membranous structures transfer cell surface proteins across NK cell immune synapses.
Williams, GS; Collinson, LM; Brzostek, J; Eissmann, P; Almeida, CR; McCann, FE; Burshtyn, D; Davis, DM;
Traffic 8:1190-1204 . doi: 10.1111/j.1600-0854.2007.00603.x
Publication date: August 31, 2007
PMID: 17605758
Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.
Yilmaz, Z; Renton, T; Yiangou, Y; Zakrzewska, J; Chessell, IP; Bountra, C; Anand, P;
Journal of Clinical Neuroscience 14:864-871 . doi: 10.1016/j.jocn.2006.09.002
Publication date: August 31, 2007
PMID: 17582772
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Bettayeb, K; Tirado, OM; Marionneau-Lambot, S; Ferandin, Y; Lozach, O; Morris, JC; Mateo-Lozano, S; Drueckes, P; Schächtele, C; Kubbutat, MHG; Liger, F; Marquet, B; Joseph, B; Echalier, A; Endicott, JA; Notario, V; Meijer, L;
Cancer Research 67:8325-8334 . doi: 10.1158/0008-5472.can-07-1826
Publication date: August 31, 2007
PMID: 17804748
Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.
Dowler, EF; Diehl, A; Schmieder, P; Brockmann, C; Elkins, J; Soundararajan, M; Oschkinat, H; Ball, LJ;
Biomolecular NMR Assignments 1:95-97 . doi: 10.1007/s12104-007-9029-9
Publication date: August 19, 2007
PMID: 19636837

July 2007

Structure and mechanism of spermidine synthases.
Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN
Biochemistry 46(28):8331-9 . doi: 10.1021/bi602498k
Publication date: July 17, 2007
PMID: 17585781
Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.
Pogacic V, Bullock AN, Fedorov O, Filippakopoulos P, Gasser C, Biondi A, Meyer-Monard S, Knapp S, Schwaller J
Cancer Res. 67(14):6916-24 . doi: 10.1158/0008-5472.CAN-07-0320
Publication date: July 15, 2007
PMID: 17638903

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