Publications

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Displaying 2201 - 2250 of 2311

2006

June 2006

Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
Barr AJ, Debreczeni JE, Eswaran J, Knapp S
Proteins 63(4):1132-6 . doi: 10.1002/prot.20958
Publication date: June 1, 2006
PMID: 16534812
Normal NK cell development in absence of Aire.
Lundgren EK, Rosmaraki E, Berg L, Hoglund P, Winqvist O
Journal of Immunology 176; S280-S280 . doi:
Publication date: June 1, 2006
PMID:
NK cells in autoimmune disease
Johansson S, Hall H, Berg L, Hoglund P.
Immunobiology of Natural Killer Cell Receptors 298; 259-77 . doi:
Publication date: June 1, 2006
PMID:

May 2006

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U
Proc. Natl. Acad. Sci. U.S.A. 103(20):7829-34 . doi: 10.1073/pnas.0601643103
Publication date: May 16, 2006
PMID: 16684881
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Bullock AN, Debreczeni JE, Edwards AM, Sundström M, Knapp S
Proc. Natl. Acad. Sci. U.S.A. 103(20):7637-42 . doi: 10.1073/pnas.0601638103
Publication date: May 16, 2006
PMID: 16675548
The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons.
Anand, U; Otto, WR; Casula, MA; Day, NC; Davis, JB; Bountra, C; Birch, R; Anand, P;
Neuroscience Letters 399:51-56 . doi: 10.1016/j.neulet.2006.01.046
Publication date: May 14, 2006
PMID: 16481104
Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination.
Griffin, RJ; Henderson, A; Curtin, NJ; Echalier, A; Endicott, JA; Hardcastle, IR; Newell, DR; Noble, MEM; Wang, L-Z; Golding, BT;
Journal of the American Chemical Society 128:6012-6013 . doi: 10.1021/ja060595j
Publication date: May 9, 2006
PMID: 16669651
The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Eswaran J, Debreczeni JE, Longman E, Barr AJ, Knapp S
Protein Sci. 15(6):1500-5 . doi: 10.1110/ps.062128706
Publication date: May 2, 2006
PMID: 16672235
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ
Biochem. J. 395(3):483-91 . doi: 10.1042/BJ20051931
Publication date: May 1, 2006
PMID: 16441242
Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer.
Williams JP, Smith DC, Green BN, Marsden BD, Jennings KR, Roberts LM, Scrivens JH
Biophys. J. 90(9):3246-54 . doi: 10.1529/biophysj.105.076455
Publication date: May 1, 2006
PMID: 16461395

April 2006

Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer
Williams, JP; Smith, DC; Green, BN; Marsden, BD; Jennings, KR; Roberts, LM; Scrivens, JH;
Biophysical Journal 90:3246-3254 . doi: 10.1529/biophysj.105.076455
Publication date: April 30, 2006
PMID: 16461395
Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.
Shafqat, N; Shafqat, J; Eissner, G; Marschall, H-U; Tryggvason, K; Eriksson, U; Gabrielli, F; Lardy, H; Jörnvall, H; Oppermann, U;
Cellular and Molecular Life Sciences 63:1205-1213 . doi: 10.1007/s00018-006-6013-y
Publication date: April 30, 2006
PMID: 16685466
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.
Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U
J. Biol. Chem. 281(15):10291-7 . doi: 10.1074/jbc.M511346200
Publication date: April 14, 2006
PMID: 16380372

March 2006

Structure and mechanism in the bacterial dihaem cytochrome c peroxidases.
Pettigrew, GW; Echalier, A; Pauleta, SR;
Journal of Inorganic Biochemistry 100:551-567 . doi: 10.1016/j.jinorgbio.2005.12.008
Publication date: March 31, 2006
PMID: 16434100
Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
Hult M, Shafqat N, Elleby B, Mitschke D, Svensson S, Forsgren M, Barf T, Vallgårda J, Abrahmsen L, Oppermann U
Mol. Cell. Endocrinol. 248(1-2):26-33 . doi: 10.1016/j.mce.2005.11.043
Publication date: March 27, 2006
PMID: 16431016
Structure and function of human 17beta-hydroxysteroid dehydrogenases.
Lukacik P, Kavanagh KL, Oppermann U
Mol. Cell. Endocrinol. 248(1-2):61-71 . doi: 10.1016/j.mce.2005.12.007
Publication date: March 27, 2006
PMID: 16414178
Molecular recognition of p53 and MDM2 by USP7/HAUSP
Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.
Nat Struct Mol Biol. 13(3):285-91 . doi:
Publication date: March 15, 2006
PMID: 16474402
Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
Kavanagh, KL; Guo, K; Wu, X; Knapp, S; Ebetino, FH; Dunford, JE; Rogers, MJ; Russell, RGG; Oppermann, U;
BONE 38:53-53 . doi: 10.1016/j.bone.2005.12.050
Publication date: March 1, 2006
PMID:
Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
Evdokimov, A; Pokross, M; Barnett, BL; Kavanagh, K; Oppermann, U; Russell, RGG; McKenna, CE; Ebetino, FH;
BONE 38:S49-S49 . doi: 10.1016/j.bone.2005.12.041
Publication date: March 1, 2006
PMID:
Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
Dunford, JE; Kavanagh, K; Oppermann, U; Ebetino, FH; Russell, RGG; Rogers, MJ;
BONE 38:S47-S48 . doi: 10.1016/j.bone.2005.12.037
Publication date: March 1, 2006
PMID:
Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
Ebetino, FH; Kashemirov, B; McKenna, CE; Evdokimov, A; Pokross, M; Barnett, BL; Dunford, J; Kavanagh, K; Rogers, MJ; Lundy, MW; Oppermann, U; Russell, RGG;
BONE 38:S49-S50 . doi: 10.1016/j.bone.2005.12.042
Publication date: March 1, 2006
PMID:

February 2006

Ruthenium half-sandwich complexes bound to protein kinase Pim-1.
Debreczeni JE, Bullock AN, Atilla GE, Williams DS, Bregman H, Knapp S, Meggers E
Angew. Chem. Int. Ed. Engl. 45(10):1580-5 . doi: 10.1002/anie.200503468
Publication date: February 27, 2006
PMID: 16381041
A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.
Krusong, K; Carpenter, EP; Bellamy, SRW; Savva, R; Baldwin, GS;
Journal of Biological Chemistry 281:4983-4992 . doi: 10.1074/jbc.M509137200
Publication date: February 24, 2006
PMID: 16306042
Disseminating structural genomics data to the public: from a data dump to an animated story
Abagyan, R; Lee, WH; Raush, E; Budagyan, L; Totrov, M; Sundstrom, M; Marsden, BD;
Trends in Biochemical Sciences 31:76-78 . doi: 10.1016/j.tibs.2005.12.006
Publication date: February 1, 2006
PMID: 16406633

January 2006

Disseminating structural genomics data to the public: from a data dump to an animated story.
Abagyan R, Lee WH, Raush E, Budagyan L, Totrov M, Sundstrom M, Marsden BD
Trends Biochem. Sci. 31(2):76-8 . doi: 10.1016/j.tibs.2005.12.006
Publication date: January 6, 2006
PMID: 16406633
SDR goes SGC: A structural genomics initiative
Oppermann, U; Kavanagh, K; Guo, KD; Ng, S; Lukacik, P; Wu, XQ; Dubinina, E; Shafqat, N; Bray, J; Marsden, B; Sharma, S; Vedadi, M; von Delft, F; Sundstrom, M;
12:235-241 . doi:
Publication date: January 1, 2006
PMID:
High-throughput structural characterisation of therapeutic protein targets
Marsden, BD; Sundstrom, M; Knapp, S;
Expert Opinion on Drug Discovery 1:123-136 . doi: 10.1517/17460441.1.2.123
Publication date: January 1, 2006
PMID:
Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus.
Echalier, A; Goodhew, CF; Pettigrew, GW; Fülöp, V;
Structure 14:107-117 . doi: 10.1016/j.str.2005.09.011
Publication date: January 1, 2006
PMID: 16407070
Erratum: Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions (Proceedings of the National Academy of Sciences of the United States of America (August 10, 2004) 101, 32 (11605-11616): 10.1073/pnas.0404332101)
Amit, R; Gileadi, O; Stavans, J;
Proceedings of the National Academy of Sciences 103:12654- . doi: 10.1073/pnas.0605122103
Publication date: January 1, 2006
PMID:
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
Yiangou, Y; Facer, P; Durrenberger, P; Chessell, IP; Naylor, A; Bountra, C; Banati, RR; Anand, P;
BMC Neurology 6:12- . doi: 10.1186/1471-2377-6-12
Publication date: January 1, 2006
PMID: 16512913
Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations.
Mukerji, G; Yiangou, Y; Corcoran, SL; Selmer, IS; Smith, GD; Benham, CD; Bountra, C; Agarwal, SK; Anand, P;
BMC Urology 6:6- . doi: 10.1186/1471-2490-6-6
Publication date: January 1, 2006
PMID: 16519806
Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening
Trosset, JY; Dalvit, C; Knapp, S; Fasolini, M; Veronesi, M; Mantegani, S; Gianellini, LM; Catana, C; Sundström, M; Stouten, PFW; Moll, JK;
Proteins 64:60-67 . doi: 10.1002/prot.20955
Publication date: January 1, 2006
PMID: 16568448
Breast stem cells and cancer.
Farnie, G; Clarke, RB;
:141-153 . doi:
Publication date: January 1, 2006
PMID: 17939300
Brain fMRI in clinical pharmacological studies
Tracey, I; Schweinhardt, P; Bountra, C;
:221-236 . doi:
Publication date: January 1, 2006
PMID:
Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.
Mukerji, G; Waters, J; Chessell, IP; Bountra, C; Agarwal, SK; Anand, P;
BMC Urology 6:31- . doi: 10.1186/1471-2490-6-31
Publication date: January 1, 2006
PMID: 17192176
Nogo-A and Nogo-66 receptor in multiple sclerosis and amyotrophic lateral sclerosis spinal cord and injured human peripheral nerves
Durrenberger, P; Facer, P; Casula, MA; Prinjha, R; Moore, S; Woodhams, P; Bountra, C; Ravid, R; Birch, R; Anand, P;
Journal of Neurology, Neurosurgery and Psychiatry 77:130-130 . doi:
Publication date: January 1, 2006
PMID:
2005

December 2005

Structure and substrate specificity of the Pim-1 kinase.
Bullock AN, Debreczeni J, Amos AL, Knapp S, Turk BE
J. Biol. Chem. 280(50):41675-82 . doi: 10.1074/jbc.M510711200
Publication date: December 16, 2005
PMID: 16227208
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ
J. Biol. Chem. 280(49):41101-10 . doi: 10.1074/jbc.M507528200
Publication date: December 9, 2005
PMID: 16186124
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Bullock AN, Debreczeni JE, Fedorov OY, Nelson A, Marsden BD, Knapp S
J. Med. Chem. 48(24):7604-14 . doi: 10.1021/jm0504858
Publication date: December 1, 2005
PMID: 16302800

November 2005

Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus.
Makyio, H; Iino, R; Ikeda, C; Imamura, H; Tamakoshi, M; Iwata, M; Stock, D; Bernal, RA; Carpenter, EP; Yoshida, M; Yokoyama, K; Iwata, S;
EMBO Journal 24:3974-3983 . doi: 10.1038/sj.emboj.7600859
Publication date: November 16, 2005
PMID: 16281059
Enzymology and Molecular Biology of Carbonyl Metabolism
Marsden, B; Oppermann, U; Kavanagh, K; Guo, K; Ng, S; Lukacik, P; Wu, X; Dubinia, E; Shafqat, N; Bray, J; Sharma, S; Vedadi, M;
12:- . doi:
Publication date: November 11, 2005
PMID:
Regulation of the wild-type and Y1235D mutant Met kinase activation.
Cristiani C, Rusconi L, Perego R, Schiering N, Kalisz HM, Knapp S, Isacchi A
Biochemistry 44(43):14110-9 . doi: 10.1021/bi051242k
Publication date: November 1, 2005
PMID: 16245927
NK cells: elusive players in autoimmunity
Johansson S, Berg L, Hall H, Hoglund P.
Trends Immunol 26(11):613-8 . doi: 10.1016/j.it.2005.08.008
Publication date: November 1, 2005
PMID: 16118064

October 2005

Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation.
Limana, F; Germani, A; Zacheo, A; Kajstura, J; Di Carlo, A; Borsellino, G; Leoni, O; Palumbo, R; Battistini, L; Rastaldo, R; Müller, S; Pompilio, G; Anversa, P; Bianchi, ME; Capogrossi, MC;
Circulation Research 97:e73-e83 . doi: 10.1161/01.RES.0000186276.06104.04
Publication date: October 13, 2005
PMID: 16166556
Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
Akutsu M, Kawasaki M, Katoh Y, Shiba T, Yamaguchi Y, Kato R, Kato K, Nakayama K, Wakatsuki S.
FEBS Lett 579(24):5385-91 . doi: 10.1016/j.febslet.2005.08.076
Publication date: October 10, 2005
PMID: 16199040

September 2005

Identification of an intestinal heme transporter.
Shayeghi, M; Latunde-Dada, GO; Oakhill, JS; Laftah, AH; Takeuchi, K; Halliday, N; Khan, Y; Warley, A; McCann, FE; Hider, RC; Frazer, DM; Anderson, GJ; Vulpe, CD; Simpson, RJ; McKie, AT;
Cell 122:789-801 . doi: 10.1016/j.cell.2005.06.025
Publication date: September 8, 2005
PMID: 16143108

August 2005

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
Kavanagh, K; Guo, K; Wu, X; Knapp, S; Ebetino, FH; Dunford, JE; Rogers, MJ; Russell, RGG; Oppermann, U;
Journal of Bone and Mineral Research 20:S95-S96 . doi:
Publication date: August 31, 2005
PMID:

July 2005

Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.
Renton, T; Yiangou, Y; Plumpton, C; Tate, S; Bountra, C; Anand, P;
BMC Oral Health 5:5- . doi: 10.1186/1472-6831-5-5
Publication date: July 6, 2005
PMID: 16001984

April 2005

Two-wavelength MAD phasing and radiation damage: a case study.
González, A; von Delft, F; Liddington, RC; Bakolitsa, C;
Journal of Synchrotron Radiation 12:285-291 . doi: 10.1107/S0909049505003249
Publication date: April 30, 2005
PMID: 15840912

March 2005

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.
Chessell, IP; Hatcher, JP; Bountra, C; Michel, AD; Hughes, JP; Green, P; Egerton, J; Murfin, M; Richardson, J; Peck, WL; Grahames, CBA; Casula, MA; Yiangou, Y; Birch, R; Anand, P; Buell, GN;
PAIN 114:386-396 . doi: 10.1016/j.pain.2005.01.002
Publication date: March 31, 2005
PMID: 15777864

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