News from SGC

Posted on Tuesday 22nd of February 2022


Toronto, February 22, 2022 – The roadmap for CACHE, an open science benchmarking initiative to enable the development of computational methods for hit-finding, has been published in Nature Reviews Chemistry.

Posted on Monday 22nd of November 2021

Toronto, November 23, 2021 – The Structural Genomics Consortium (SGC) is pleased to announce a new research initiative, funded by The Michael J. Fox Foundation for Parkinson’s Research, focusing on the WD domain of LRRK2. Using computational methods, this initiative will explore complementary and novel therapeutic strategies to target LRRK2.

Posted on Thursday 11th of November 2021

Cyclica and Structural Genomics Consortium co-crystallize DCAF1, a key component in proteasomal degradation, with a novel ligand to support targeted therapeutics discovery

11 November, 2021

Toronto, Canada

Cyclica, the partner of choice for data-driven drug discovery, and the Structural Genomics Consortium (SGC), a global public-private partnership dedicated to open science, have collaborated on a project in support of Target 2035, an initiative to discover probe molecules in support of developing medicines for all.

Posted on Thursday 7th of October 2021


New look for Target 2035

SGC’s Target 2035 initiative just launched a new website with a fresh look and feel. Users will be able to access information about the project, upcoming webinars, and general updates. Check the Target 2035 Twitter and Linked In accounts for the latest news.

What is Target 2035

Posted on Friday 12th of February 2021

Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.

Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto, showed that chemically inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells.

Posted on Thursday 10th of September 2020

On September 8th, 2020, the Royal Society of Canada (RSC) elected Dr. Cheryl Arrowsmith, SGC-Toronto's Chief Scientist, as an RSC Fellow, the highest honour an individual can achieve in the Arts, Social Sciences and Sciences. 

Posted on Tuesday 1st of September 2020

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD) and is also linked to its idiopathic form. LRRK2 is proposed to function in membrane trafficking and co-localizes with microtubules. Despite LRRK2’s fundamental importance for understanding and treating PD, there is limited structural information on it.

Posted on Friday 15th of May 2020

SGC Director, Aled Edwards, speaks to The Future Economy on why Open Science is important in fighting COVID-19, and other related questions, in their series "The COVID-19 Rebound". You can see the full interview here:


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