News from SGC

Posted on Thursday 10th of September 2020

On September 8th, 2020, the Royal Society of Canada (RSC) elected Dr. Cheryl Arrowsmith, SGC-Toronto's Chief Scientist, as an RSC Fellow, the highest honour an individual can achieve in the Arts, Social Sciences and Sciences. 

Posted on Tuesday 1st of September 2020

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD) and is also linked to its idiopathic form. LRRK2 is proposed to function in membrane trafficking and co-localizes with microtubules. Despite LRRK2’s fundamental importance for understanding and treating PD, there is limited structural information on it.

Posted on Friday 15th of May 2020

SGC Director, Aled Edwards, speaks to The Future Economy on why Open Science is important in fighting COVID-19, and other related questions, in their series "The COVID-19 Rebound". You can see the full interview here: https://thefutureeconomy.ca/interviews/aled-edwards/

Posted on Friday 1st of May 2020

We determined the structure of the TASK-1 potassium ion channel. Mutations in TASK-1 are linked to pulmonary arterial hypertension.

TASK-1 has an unusual X-gate, consisting of two crossed helices. This type of gate is not present in related potassium channels and explains the low activity of TASK-1. We also crystallised TASK-1 in complex with inhibitors and found that they bind in the central cavity, trapped by the X-gate.

This work is a collaboration with Bayer AG and University of Marburg.

Rodstrom et al., Nature, Advanced on line publication

Posted on Thursday 9th of April 2020

 

 

(Chapel Hill, N.C.— April 7, 2020) — Today, the Structural Genomics Consortium (SGC), the University of North Carolina at Chapel Hill and the Eshelman Institute for Innovation, announce the launch of the Rapidly Emerging Antiviral Drug Development Initiative (READDI), a global organization formed to discover and develop drugs to put “on the shelf” for clinical trial testing in anticipation of future viral pandemics.

Posted on Monday 2nd of March 2020

Launch of a New Phase 2 Clinical Trial “STOPFOP”

The Saracatinib trial to prevent Fibrodysplasia Ossificans Progressiva (STOPFOP) will begin recruitment in March 2020.

Posted on Friday 28th of February 2020

February 28, 2020

The Chordoma Foundation (CF) and The Mark Foundation for Cancer Research (MFCR) announced today a two-year, $1.4M partnership with a team of researchers at three institutions to develop new treatments for chordoma, a rare and difficult-to-treat bone cancer. The researchers will focus on creating the first drugs to inhibit a protein known as brachyury.

Posted on Monday 2nd of December 2019

Photo: CHERYL ARROWSMITH AND LEVON HALABELIAN

December 2, 2019 (Toronto)

Posted on Tuesday 1st of October 2019

 SGC and collaborating institutions will lead development of openly distributed tools to test the efficacy of Alzheimer’s therapies and rapidly share results

The National Institute on Aging (NIA), part of the National Institutes of Health, has awarded a grant expected to total $37.5 million over five years to establish the Open-AD Drug Discovery Center. Led by Emory University, the Center includes investigators at Sage Bionetworks, Structural Genomics Consortium (SGC), Stanford University, Oxford University, and University of North Carolina.

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