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In the most recent issue of Nature Chemical Biology, SGC-Toronto and Abbvie researchers share the results of their collaboration to create the first-in-class chemical probe for SUV4-20. A-196, an open access potent and selective inhibitor for SUV4-20, decreases H4K20 methylation and alters the DNA damage response, and is a useful tool to investigate the regulation of genomic integrity.
For the Nature Chemical Biology paper: http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2282....