News from SGC

SGC and Abbvie scientists have published a research article in Nature Chemical Biology reporting a chemical probe for embryonic ectoderm development (EED) protein. The open-access probe, A-395, binds to EED inhibiting protein-protein interaction and inactivating the Polycomb repressive complex 2 (PRC2). PRC2 is dysregulated in many cancers and is a potential target for therapy.

Earlier this month, SGC and Abbvie reported on another collaboration resulting in A-196, a first-in-class open-access inhibitor against SUV4-20.

In the most recent issue of Nature Chemical Biology, SGC-Toronto and Abbvie researchers share the results of their collaboration to create the first-in-class chemical probe for SUV4-20. A-196, an open access potent and selective inhibitor for SUV4-20, decreases H4K20 methylation and alters the DNA damage response, and is a useful tool to investigate the regulation of genomic integrity. 

For the Nature Chemical Biology paper: http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2282....

In this TEDxToronto talk, SGC Director, Aled Edwards, outlines the case for open science as a key to the development of cures and global advancement.

http://www.tedxtoronto.com/speakers/aled-edwards

Scientists from the Structural Genomics Consortium (SGC) and Oxford University report the first potent and selective chemical probe for the bromodomain of PCAF in an article published in Angewandte Chemie International Edition