June 16th, 2017- SGC’s Target Enabling Package (TEP) Evaluation Group has approved five new TEPs for protein targets related to cancer, metabolic diseases and neuropsychiatric disorders.
TEPs enable scientists to research understudied proteins that have been genetically linked to human disease. The SGC generates and disseminates structural data, assays and other key research information and tools on these proteins to the scientific community.
The five TEPs recently released focus on the following genes:
Scientists have utilised Diamond Light Source to develop a new method to extract previously hidden information from the X-ray diffraction data that are measured when resolving the three-dimensional (3D) atomic structures of proteins and other biological molecules.
The international research consortium SGC and SciLifeLab aim to give researchers access to well-validated research tool antibodies.
[by Susanne Gräslund, SGC Karolinska, Helena Persson Lotsholm,DDDP SciLifeLab, Per I Arvidsson, Director DDDP SciLifeLab, Mikael Sundström, Director SGC European activities]
SGC and Abbvie scientists have published a research article in Nature Chemical Biology reporting a chemical probe for embryonic ectoderm development (EED) protein. The open-access probe, A-395, binds to EED inhibiting protein-protein interaction and inactivating the Polycomb repressive complex 2 (PRC2). PRC2 is dysregulated in many cancers and is a potential target for therapy.
Earlier this month, SGC and Abbvie reported on another collaboration resulting in A-196, a first-in-class open-access inhibitor against SUV4-20.
The IFOPA and FOP Friends® UK have joined together to co-fund a new study at the University of Oxford.
Alex Bullock, who established the University of Oxford FOP Research Team with Professor Jim Triffit, is optimistic that this new research technique “could lead to the development of a new class of inhibitor drug for FOP therapy.”
In the most recent issue of Nature Chemical Biology, SGC-Toronto and Abbvie researchers share the results of their collaboration to create the first-in-class chemical probe for SUV4-20. A-196, an open access potent and selective inhibitor for SUV4-20, decreases H4K20 methylation and alters the DNA damage response, and is a useful tool to investigate the regulation of genomic integrity.
For the Nature Chemical Biology paper: http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2282....
Rachel Harding, a postdoctoral fellow at SGC-Toronto, writes in this online Nature blog about her open lab notebook experiences sharing her Huntington’s disease research data in real-time.
In this TEDxToronto talk, SGC Director, Aled Edwards, outlines the case for open science as a key to the development of cures and global advancement.