News from SGC

Posted on Tuesday 18th of December 2018

Lysine acetylation has emerged as a key regulatory modification on histones and other proteins. Histone de-acetylaces (HDACs, the enzymes that remove lysine acetylation (Kac) from histones) are now validated drug targets in cancer, with four FDA approved drugs and several clinical trials seeking to establish higher efficacy and specificity. Kac is recognized by small protein interaction modules called bromodomains (BRDs), leading to the aggregation of complexes involved in transcription and contributing to the control of gene expression (Filippakopoulos et al., 2012; Fujisawa and Filippakopoulos, 2017).

Posted on Tuesday 18th of December 2018

SGC Toronto will host the Protac symposium on March 4th 2019. Please visit the symposium page for more details.

Posted on Monday 3rd of December 2018

Stefan Knapp, CSO of the SGC Frankfurt is one of the worlds’ most influential scientists as revealed by Clarivate Analytics’ Highly Cited Researchers List. He has been selected for his exceptional performance in the newly introduced category “Cross-Field”, based on his multiple high impact papers published across several fields. more

Posted on Wednesday 9th of May 2018

With this unique project, several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have entered into a pre-competitive collaboration with the SGC, to make a large number of innovative high-quality probes available to the research community which can be found here:

Posted on Friday 16th of March 2018

The aim of this conference is to explore the mechanisms of BMP signal transduction and to discuss how genetic and epigenetic alterations result in aberrant signalling and how this leads to cancer. Microenvironmental control of cancer cell function is a research area of intense interest and as a key mesenchymal-epithelial signalling pathway, BMP signalling is emerging as a key therapeutic target. We aim to discuss in detail how to manipulate the pathway, both positively and negatively with small molecules or biologics.

Posted on Wednesday 7th of March 2018
ALS Reproducible Antibody Platform
March 8, 2018
Press release – FINAL Contact:
Brian Frederick
The ALS Association


The ALS Association Partners with the Motor Neurone Disease Association and the ALS Society of Canada to Establish the ALS Reproducible Antibody Platform

Posted on Wednesday 28th of February 2018

February 28, 2018

Open Source Drug Discovery

By: Aled Edwards and Aidan Hollis

A recent study claims that almost 1 million Canadians give up food and heat to afford prescriptions. This is just a harbinger of things to come because the current business model that drives the discovery of innovative pharmaceutical treatments requires higher and higher prices. As one example, Luxturna, a new treatment for an eye disease, is priced at a staggering $1 million per course of treatment.

Posted on Tuesday 13th of February 2018

The Neuro-SGC and our collaborators at the Montreal Neurological Institute (The Neuro) are using Open Science and sharing to help find treatments to millions of patients with devastating neurodegenerative disorders. Read a review of their approach in this month's issue of Frontiers in Neuroscience:

Posted on Tuesday 13th of February 2018

Two of the largest pharmaceutical companies in Brazil, Aché Laboratories and Eurofarma Laboratories, have partnered with the Brazilian Agency for Industrial Research and Innovation (Embrapii) to fund a medicinal chemistry project at the SGC lab at UNICAMP, Campinas, SP, Brazil.

Aché and Eurofarma will each provide R$2.4M funding over six years with R$3.6M from Embrapii to form the Embrapii “Centro de Química Medicinal de Inovação Aberta” (CQMED, English: “Centre for Open Innovation Medicinal Chemistry”).

Posted on Thursday 11th of January 2018

Kiev, Ukraine and Oxford, UK, 10 January 2018: Diamond Light Source (Diamond) and the Structural Genomic Consortium (SGC) Oxford announced today that Enamine, a chemical company and producer of novel chemical building blocks and screening libraries, will become a key supplier of poised fragment and analogue libraries to its XChem facility. Enamine will offer a new generation of the hit-finding library, Diamond-SGC-iNEXT (DSI) Poised Library to enable fast and productive fragment-based lead discovery(FBLD).


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