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OICR-41103 A chemical probe for DCAF1.

The probe and control may be requested here.

overview
co-crystal structures

overview

A collaboration between the Drug Discovery Program at the Ontario Institute for Cancer Research (OICR) and the Structural Genomics Consortium (SGC) has resulted in the discovery of OICR-41103, a chemical probe for DCAF1 (DDB1-Cul4 associated factor 1).

OICR-41103 binds potently to DCAF1-WDR with a K_D value of 2 nM (SPR). In a nanoBRET assay, OICR-41103 displaces a tracer (chemically based on a literature molecule) from DCAF1-WDR with EC₅₀/EC₉₀ values of 130 and 700 nM, respectively.

Probe		Negative control

OICR-41103		OICR-41103N

properties

selectivity profile

in vitro potency

cell based assay data

references

pk properties

co-crystal structures

https://www.rcsb.org/structure/9D4E

synthetic schemes

materials and methods

17.09.2024

Celebrating the Impact of SGC Postdocs on Open Science

by: SGC

This week, in honor of National Postdoc Appreciation Week, we are excited to spotlight the incredible contributions of the Structural Genomics Consortium (SGC) postdoctoral researchers across all our research sites. These talented individuals are the engine driving forward innovative, open-access research in previously unexplored areas of biology.