Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro. Read more about Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro.
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations. Read more about Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.
DARPin-induced reactivation of p53 in HPV-positive cells. Read more about DARPin-induced reactivation of p53 in HPV-positive cells.
Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. Read more about Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain. Read more about Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling. Read more about Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling.
Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve. Read more about Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve.
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity. Read more about Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity. Read more about A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity.
