Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation. Read more about Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation.
Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target. Read more about Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target.
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro. Read more about Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro.
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations. Read more about Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.
DARPin-induced reactivation of p53 in HPV-positive cells. Read more about DARPin-induced reactivation of p53 in HPV-positive cells.
Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. Read more about Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain. Read more about Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling. Read more about Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling.
