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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers.

  • Read more about PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers.

Structural basis of human CYP51 inhibition by antifungal azoles.

  • Read more about Structural basis of human CYP51 inhibition by antifungal azoles.

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

  • Read more about Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

The (un)targeted cancer kinome.

  • Read more about The (un)targeted cancer kinome.

Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.

  • Read more about Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.

Open-access public-private partnerships to enable drug discovery--new approaches.

  • Read more about Open-access public-private partnerships to enable drug discovery--new approaches.

Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

  • Read more about Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

  • Read more about Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

Structural genomics-impact on biomedicine and drug discovery.

  • Read more about Structural genomics-impact on biomedicine and drug discovery.

Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

  • Read more about Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

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