The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Read more about The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival. Read more about A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.
Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector. Read more about Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.
Structural biology of human H3K9 methyltransferases. Read more about Structural biology of human H3K9 methyltransferases.
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Read more about Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. Read more about Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
A miniaturized screen for inhibitors of Jumonji histone demethylases. Read more about A miniaturized screen for inhibitors of Jumonji histone demethylases.
Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Read more about Toward a unified nomenclature for mammalian ADP-ribosyltransferases.
Pharmacophore screening of the protein data bank for specific binding site chemistry. Read more about Pharmacophore screening of the protein data bank for specific binding site chemistry.
A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Read more about A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
