Pharmacophore screening of the protein data bank for specific binding site chemistry. Read more about Pharmacophore screening of the protein data bank for specific binding site chemistry.
A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Read more about A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Read more about PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers.
Structural basis of human CYP51 inhibition by antifungal azoles. Read more about Structural basis of human CYP51 inhibition by antifungal azoles.
Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering. Read more about Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display. Read more about Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.
Open-access public-private partnerships to enable drug discovery--new approaches. Read more about Open-access public-private partnerships to enable drug discovery--new approaches.
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. Read more about Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.
Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. Read more about Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.
