Publications

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2010

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN

J. Mol. Biol.. 401(3):389-402. doi: 10.1016/j.jmb.2010.06.017

Publication date: August 20, 2010

PMID: 20561531

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.

Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, Ferguson MA

Glycobiology. 20(12):1619-30. doi: 10.1093/glycob/cwq115

Publication date: August 19, 2010

PMID: 20724435

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ

J. Mol. Biol.. 401(2):211-22.

Publication date: August 13, 2010

PMID: 20684070

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J

J. Med. Chem.. 53(15):5844-57. doi: 10.1021/jm100478y

Publication date: August 12, 2010

PMID: 20614940

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH

PLoS ONE. 5(8):e11905. doi: 10.1371/journal.pone.0011905

Publication date: August 6, 2010

PMID: 20730082

A software tool to accelerate design of protein constructs for recombinant expression.

Sagemark J, Kraulis P, Weigelt J

Protein Expr. Purif.. 72(2):175-8. doi: 10.1016/j.pep.2010.03.020

Publication date: August 1, 2010

PMID: 20359538

Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis.

Wigle TJ, Provencher LM, Norris JL, Jin J, Brown PJ, Frye SV, Janzen WP

Chem. Biol.. 17(7):695-704. doi: 10.1016/j.chembiol.2010.04.014

Publication date: July 30, 2010

PMID: 20659682

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S

PLoS Biol.. 8(7):e1000439. doi: 10.1371/journal.pbio.1000439

Publication date: July 27, 2010

PMID: 20676357

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S

PLoS Biol.. 8(7):e1000426. doi: 10.1371/journal.pbio.1000426

Publication date: July 27, 2010

PMID: 20668654

Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.

Schütz P, Wahlberg E, Karlberg T, Hammarström M, Collins R, Flores A, Schüler H

J. Mol. Biol.. 400(4):768-82. doi: 10.1016/j.jmb.2010.05.046

Publication date: July 23, 2010

PMID: 20510246

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.

Karlberg T, Markova N, Johansson I, Hammarström M, Schütz P, Weigelt J, Schüler H

J. Med. Chem.. 53(14):5352-5. doi: 10.1021/jm100249w

Publication date: July 22, 2010

PMID: 20565110

Targeting kinases for the treatment of inflammatory diseases.

Müller S, Knapp S

Expert Opin Drug Discov. 5(9):867-81. doi: 10.1517/17460441.2010.504203

Publication date: July 15, 2010

PMID: 22823261

Quinone oxidoreductase-2-mediated prodrug cancer therapy.

Middleton MR, Knox R, Cattell E, Oppermann U, Midgley R, Ali R, Auton T, Agarwal R, Anderson D, Sarker D, Judson I, Osawa T, Spanswick VJ, Davies S, Hartley JA, Kerr DJ

Sci Transl Med. 2(40):40ra50. doi: 10.1126/scitranslmed.3000615

Publication date: July 14, 2010

PMID: 20630857

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.

Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE

Proc. Natl. Acad. Sci. U.S.A.. 107(28):12593-8. doi: 10.1073/pnas.0909087107

Publication date: July 13, 2010

PMID: 20571119

Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.

Bacik JP, Walker JR, Ali M, Schimmer AD, Dhe-Paganon S

J. Biol. Chem.. 285(26):20273-80. doi: 10.1074/jbc.M110.102921

Publication date: June 25, 2010

PMID: 20368332

Architecture of Eph receptor clusters.

Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S

Proc. Natl. Acad. Sci. U.S.A.. 107(24):10860-5. doi: 10.1073/pnas.1004148107

Publication date: June 15, 2010

PMID: 20505120

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V

J. Biol. Chem.. 285(24):18452-63. doi: 10.1074/jbc.M109.077925

Publication date: June 11, 2010

PMID: 20207735

High-throughput production of human proteins for crystallization: the SGC experience.

Savitsky P, Bray J, Cooper CD, Marsden BD, Mahajan P, Burgess-Brown NA, Gileadi O

J. Struct. Biol.. 172(1):3-13. doi: 10.1016/j.jsb.2010.06.008

Publication date: June 10, 2010

PMID: 20541610

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.

Healy S, McDonald MK, Wu X, Yue WW, Kochan G, Oppermann U, Gravel RA

Biochemistry. 49(22):4687-94. doi: 10.1021/bi901612y

Publication date: June 8, 2010

PMID: 20443544

Mass spectrometry following mild enzymatic digestion reveals phosphorylation of recombinant proteins in Escherichia coli through mechanisms involving direct nucleotide binding.

She YM, Xu X, Yakunin AF, Dhe-Paganon S, Donald LJ, Standing KG, Lee DC, Jia Z, Cyr TD

J. Proteome Res.. 9(6):3311-8. doi: 10.1021/pr9011987

Publication date: June 4, 2010

PMID: 20405931

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ

Bioorg. Med. Chem. Lett.. 20(11):3387-93. doi: 10.1016/j.bmcl.2010.04.015

Publication date: June 1, 2010

PMID: 20451379

Towards proteome scale antibody selections using phage display.

Mersmann M, Meier D, Mersmann J, Helmsing S, Nilsson P, Gräslund S, Colwill K, Hust M, Dübel S

N Biotechnol. 27(2):118-28. doi: 10.1016/j.nbt.2009.10.007

Publication date: May 31, 2010

PMID: 19883803

Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR

J. Biol. Chem.. 285(21):16218-30. doi: 10.1074/jbc.M109.070953

Publication date: May 21, 2010

PMID: 20207729

Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

Hong BS, Allali-Hassani A, Tempel W, Finerty PJ, Mackenzie F, Dimov S, Vedadi M, Park HW

J. Biol. Chem.. 285(21):16330-40. doi: 10.1074/jbc.M109.039024

Publication date: May 21, 2010

PMID: 20299452

Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.

Jörnvall H, Hedlund J, Bergman T, Oppermann U, Persson B

Biochem. Biophys. Res. Commun.. 396(1):125-30. doi: 10.1016/j.bbrc.2010.03.094

Publication date: May 21, 2010

PMID: 20494124

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.

Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD

Nature. 465(7296):359-62. doi: 10.1038/nature09022

Publication date: May 20, 2010

PMID: 20485436

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW

J. Mol. Biol.. 398(4):497-506. doi: 10.1016/j.jmb.2010.03.034

Publication date: May 14, 2010

PMID: 20346956

Biophysical characterization of recombinant proteins: a key to higher structural genomics success.

Vedadi M, Arrowsmith CH, Allali-Hassani A, Senisterra G, Wasney GA

J. Struct. Biol.. 172(1):107-19. doi: 10.1016/j.jsb.2010.05.005

Publication date: May 11, 2010

PMID: 20466062

A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

Quinn AM, Allali-Hassani A, Vedadi M, Simeonov A

Mol Biosyst. 6(5):782-8. doi: 10.1039/b921912a

Publication date: May 10, 2010

PMID: 20567762

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.

Wernimont AK, Artz JD, Finerty P, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R

Nat. Struct. Mol. Biol.. 17(5):596-601. doi: 10.1038/nsmb.1795

Publication date: May 2, 2010

PMID: 20436473

Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite.

Huttu J, Singh BK, Bhargav SP, Sattler JM, Schüler H, Kursula I

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 66(Pt 5):583-7. doi: 10.1107/S1744309110011589

Publication date: May 1, 2010

PMID: 20445265

Structural genomics-impact on biomedicine and drug discovery.

Weigelt J

Exp. Cell Res.. 316(8):1332-8. doi: 10.1016/j.yexcr.2010.02.041

Publication date: May 1, 2010

PMID: 20211166

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.

Kallberg Y, Oppermann U, Persson B

FEBS J.. 277(10):2375-86. doi: 10.1111/j.1742-4658.2010.07656.x

Publication date: April 29, 2010

PMID: 20423462

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

López-Ramos M, Prudent R, Moucadel V, Sautel CF, Barette C, Lafanechère L, Mouawad L, Grierson D, Schmidt F, Florent JC, Filippakopoulos P, Bullock AN, Knapp S, Reiser JB, Cochet C

FASEB J.. 24(9):3171-85. doi: 10.1096/fj.09-143743

Publication date: April 16, 2010

PMID: 20400536

Finding Inspiration in the Protein Data Bank to Chemically Antagonize Readers of the Histone Code.

Campagna-Slater V, Schapira M

Mol Inform. 29(4):322-31. doi: 10.1002/minf.201000018

Publication date: April 12, 2010

PMID: 27463059

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS

Nat. Chem. Biol.. 6(5):359-68. doi: 10.1038/nchembio.345

Publication date: April 11, 2010

PMID: 20383151

Structural basis of human CYP51 inhibition by antifungal azoles.

Strushkevich N, Usanov SA, Park HW

J. Mol. Biol.. 397(4):1067-78. doi: 10.1016/j.jmb.2010.01.075

Publication date: April 9, 2010

PMID: 20149798

Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.

Hliscs M, Sattler JM, Tempel W, Artz JD, Dong A, Hui R, Matuschewski K, Schüler H

J. Biol. Chem.. 285(15):11572-83. doi: 10.1074/jbc.M109.054916

Publication date: April 9, 2010

PMID: 20083609

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG

Nature. 464(7289):728-32. doi: 10.1038/nature08893

Publication date: April 1, 2010

PMID: 20360736

Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity.

Zhao R, Leung E, Grüner S, Schapira M, Houry WA

PLoS ONE. 5(4):e9934. doi: 10.1371/journal.pone.0009934

Publication date: April 1, 2010

PMID: 20376192

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F

Trends Biochem. Sci.. 35(4):208-19. doi: 10.1016/j.tibs.2009.12.003

Publication date: April 1, 2010

PMID: 20106667

Pharmacophore screening of the protein data bank for specific binding site chemistry.

Campagna-Slater V, Arrowsmith AG, Zhao Y, Schapira M

J Chem Inf Model. 50(3):358-67. doi: 10.1021/ci900427b

Publication date: March 22, 2010

PMID: 20112952

Probing the structural basis of RecQ helicase function.

Vindigni A, Marino F, Gileadi O

Biophys. Chem.. 149(3):67-77. doi: 10.1016/j.bpc.2010.03.012

Publication date: March 20, 2010

PMID: 20392558

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.

Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD

Blood. 115(11):2251-9. doi: 10.1182/blood-2009-07-231191

Publication date: March 18, 2010

PMID: 20075161

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T

J. Biol. Chem.. 285(11):8054-60. doi: 10.1074/jbc.M109.077834

Publication date: March 12, 2010

PMID: 20064938

Open-access public-private partnerships to enable drug discovery--new approaches.

Müller S, Weigelt J

IDrugs. 13(3):175-80.

Publication date: March 2, 2010

PMID: 20191434

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ

J. Med. Chem.. 53(4):1810-8. doi: 10.1021/jm901680b

Publication date: February 25, 2010

PMID: 20088513

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA

FEBS Lett.. 584(4):825-30. doi: 10.1016/j.febslet.2009.12.055

Publication date: February 19, 2010

PMID: 20067792

Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.

Pershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J

Protein Eng. Des. Sel.. 23(4):279-88. doi: 10.1093/protein/gzq003

Publication date: February 17, 2010

PMID: 20164216

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

Karlberg T, Hammarström M, Schütz P, Svensson L, Schüler H

Biochemistry. 49(6):1056-8. doi: 10.1021/bi902079y

Publication date: February 16, 2010

PMID: 20092359

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