Publications

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Displaying 2251 - 2300 of 2418

2007

March 2007

Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Elkins, JM; Papagrigoriou, E; Berridge, G; Yang, X; Phillips, C; Gileadi, C; Savitsky, P; Doyle, DA;
Protein Science 16:683-694 . doi:
Publication date: March 31, 2007
PMID: 17384233
Insights for the development of specific kinase inhibitors by targeted structural genomics.
Fedorov O, Sundström M, Marsden B, Knapp S
Drug Discov. Today 12(9-10):365-72 . doi: 10.1016/j.drudis.2007.03.006
Publication date: March 29, 2007
PMID: 17467572
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.
Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN
Structure 15(3):377-89 . doi: 10.1016/j.str.2007.02.002
Publication date: March 16, 2007
PMID: 17355872
Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection
Wagner CS, Riise GC, Bergstrom T, Karre K, Carbone E, Berg L.
J Immunol. 178(6):3536-43 . doi: 10.4049/jimmunol.178.6.3536
Publication date: March 15, 2007
PMID: 17339449
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Kavanagh K, Lee WH, Hwa Lee W, Adamski J, Oppermann U
Biochem. J. 402(3):419-27 . doi: 10.1042/BJ20061319
Publication date: March 15, 2007
PMID: 17067289
The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.
McCann, FE; Eissmann, P; Onfelt, B; Leung, R; Davis, DM;
Journal of Immunology 178:3418-3426 . doi: 10.4049/jimmunol.178.6.3418
Publication date: March 15, 2007
PMID: 17339436
A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.
Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP
J. Med. Chem. 50(5):915-21 . doi: 10.1021/jm060827p
Publication date: March 8, 2007
PMID: 17290979
AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.
Carpenter, EP; Corbett, A; Thomson, H; Adacha, J; Jensen, K; Bergeron, J; Kasampalidis, I; Exley, R; Winterbotham, M; Tang, C; Baldwin, GS; Freemont, P;
EMBO Journal 26:1363-1372 . doi: 10.1038/sj.emboj.7601593
Publication date: March 7, 2007
PMID: 17318183
Structure and regulation of the human Nek2 centrosomal kinase.
Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Fedorov O, Shen QY, Fry AM, Knapp S, Smerdon SJ
J. Biol. Chem. 282(9):6833-42 . doi: 10.1074/jbc.M609721200
Publication date: March 2, 2007
PMID: 17197699
An NMR-based metabolic profiling study of inflammatory pain using the rat FCA model
Connor, SC; Gray, RA; Hodson, MP; Clayton, NM; Haselden, JN; Chessell, IP; Bountra, C;
Metabolomics 3:29-39 . doi: 10.1007/s11306-006-0039-x
Publication date: March 1, 2007
PMID:
Structural genomics and drug discovery: Case studies on human metabolic enzymes
Oppermann, U; Kavanagh, KL; Guo, K; Ng, S; Shafqat, N; Danford, J; Rojkova, A; Pilka, E; Hozjan, V; Kochan, G; Wu, X; Lukacik, P;
Naunyn-Schmiedeberg's Archives of Pharmacology 375:69-69 . doi:
Publication date: March 1, 2007
PMID:

February 2007

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities.
Wu X, Knapp S, Stamp A, Stammers DK, Jörnvall H, Dellaporta SL, Oppermann U
FEBS J. 274(5):1172-82 . doi: 10.1111/j.1742-4658.2007.05642.x
Publication date: February 15, 2007
PMID: 17298439
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR, Knapp S
Structure 15(2):201-13 . doi: 10.1016/j.str.2007.01.001
Publication date: February 13, 2007
PMID: 17292838
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Davis TL, Walker JR, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S
J. Mol. Biol. 366(1):216-29 . doi: 10.1016/j.jmb.2006.11.037
Publication date: February 9, 2007
PMID: 17157313
Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer.
Barnes, NLP; Warnberg, F; Farnie, G; White, D; Jiang, W; Anderson, E; Bundred, NJ;
British Journal of Cancer 96:575-582 . doi: 10.1038/sj.bjc.6603593
Publication date: February 6, 2007
PMID: 17285134
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.
Johansson C, Kavanagh KL, Gileadi O, Oppermann U
J. Biol. Chem. 282(5):3077-82 . doi: 10.1074/jbc.M608179200
Publication date: February 2, 2007
PMID: 17121859
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.
Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H
J. Biol. Chem. 282(5):3182-7 . doi: 10.1074/jbc.M609838200
Publication date: February 2, 2007
PMID: 17138556
The centaurin gamma-1 GTPase-like domain functions as an NTPase.
Soundararajan, M; Yang, X; Elkins, JM; Sobott, F; Doyle, DA;
Biochemical Journal 401:679-688 . doi: 10.1042/BJ20060555
Publication date: February 1, 2007
PMID: 17037982
The effect of inflammation on Fos expression in the ferret trigeminal nucleus.
Worsley, MA; Davies, SL; Clayton, NM; Bountra, C; Loescher, AR; Robinson, PP; Boissonade, FM;
European Journal of Oral Sciences 115:40-47 . doi: 10.1111/j.1600-0722.2007.00411.x
Publication date: February 1, 2007
PMID: 17305715

January 2007

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.
Wu X, Lukacik P, Kavanagh KL, Oppermann U
Mol. Cell. Endocrinol. 265-266:71-6 . doi: 10.1016/j.mce.2006.12.006
Publication date: January 17, 2007
PMID: 17234335
Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family.
Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovsky L, Pan PW, Vedadi M, Plotnikov AN, Edwards A, Arrowsmith C, Thornton JM
Bioinformatics 23(2):e104-9 . doi: 10.1093/bioinformatics/btl292
Publication date: January 15, 2007
PMID: 17237076
Total Synthesis of Rapamycin
Maddess, ML; Tackett, MN; Watanabe, H; Brennan, PE; Spilling, CD; Scott, JS; Osborn, DP; Ley, SV;
Angewandte Chemie International Edition 46:591-597 . doi: 10.1002/anie.200604053
Publication date: January 15, 2007
PMID:
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy.
Sánchez, D; Anand, U; Gorelik, J; Benham, CD; Bountra, C; Lab, M; Klenerman, D; Birch, R; Anand, P; Korchev, Y;
Journal of Neuroscience Methods 159:26-34 . doi: 10.1016/j.jneumeth.2006.06.018
Publication date: January 15, 2007
PMID: 16887195
Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
Vogler, M; Dürr, K; Jovanovic, M; Debatin, K-M; Fulda, S;
Oncogene 26:248-257 . doi: 10.1038/sj.onc.1209776
Publication date: January 11, 2007
PMID:
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.
Facer, P; Casula, MA; Smith, GD; Benham, CD; Chessell, IP; Bountra, C; Sinisi, M; Birch, R; Anand, P;
BMC Neurology 7:11- . doi: 10.1186/1471-2377-7-11
Publication date: January 1, 2007
PMID: 17521436
Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts.
Atherton, DD; Facer, P; Roberts, KM; Misra, VP; Chizh, BA; Bountra, C; Anand, P;
BMC Neurology 7:21- . doi: 10.1186/1471-2377-7-21
Publication date: January 1, 2007
PMID: 17683543
Erratum: Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity (Biochemical Journal (2007) 402, (419-427))
Lukacik, P; Keller, B; Bunkoczi, G; Kavanagh, KL; Lee, WH; Adamski, J; Oppermann, U;
Biochemical Journal 403:615- . doi:
Publication date: January 1, 2007
PMID:
Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
Dunford, JE; Kavanagh, KL; Rogers, MJ; Oppermann, U; Ebetin, FH; Russell, G;
Calcified Tissue International 80:S41-S42 . doi:
Publication date: January 1, 2007
PMID:
High-level bacterial expression and purification of apicomplexan micronemal proteins for structural studies.
Saouros, S; Blumenschein, TMA; Sawmynaden, K; Marchant, J; Koutroukides, T; Liu, B; Simpson, P; Carpenter, EP; Matthews, SJ;
Protein and Peptide Letters 14:411-415 . doi:
Publication date: January 1, 2007
PMID: 17584164
The cell-binding region of Toxoplasma gondii micronemal protein 1 presents a novel fold
Blumenschein, TMA; Carpenter, EP; Saciuros, S; Friedrich, N; Koutroukides, T; Soldati, D; Matthews, S;
Biophysical Journal :43A-43A . doi:
Publication date: January 1, 2007
PMID:
Molecular replacement
Murshudov, G; Von Delft, F; Ballard, C;
Acta Crystallographica Section D: Biological Crystallography 64:- . doi: 10.1107/S0907444907058714
Publication date: January 1, 2007
PMID: 18376450
Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.
Sitia, G; Iannacone, M; Müller, S; Bianchi, ME; Guidotti, LG;
Journal of Leukocyte Biology 81:100-107 . doi: 10.1189/jlb.0306173
Publication date: January 1, 2007
PMID: 16935945
2006

December 2006

Resonance assignment of the RGS domain of human RGS10.
Fedorov OY, Higman VA, Schmieder P, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ
J. Biomol. NMR 38(2):191 . doi: 10.1007/s10858-006-9111-0
Publication date: December 19, 2006
PMID: 17180548
Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).
Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S
J. Biol. Chem. 281(49):38061-70 . doi: 10.1074/jbc.M606704200
Publication date: December 8, 2006
PMID: 17035239
NMR assignment of human RGS18.
Higman, VA; Leidert, M; Diehl, A; Elkins, J; Soundararajan, M; Oschkinat, H; Ball, LJ;
Journal of Biomolecular NMR 36 Suppl 1:72- . doi: 10.1007/s10858-006-9061-6
Publication date: December 1, 2006
PMID: 16964532

November 2006

Structural basis for protein-protein interactions in the 14-3-3 protein family.
Yang, X; Lee, WH; Sobott, F; Papagrigoriou, E; Robinson, CV; Grossmann, JG; Sundström, M; Doyle, DA; Elkins, JM;
Proceedings of the National Academy of Sciences 103:17237-17242 . doi: 10.1073/pnas.0605779103
Publication date: November 14, 2006
PMID: 17085597
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R
Mol. Biochem. Parasitol. 151(1):100-10 . doi: 10.1016/j.molbiopara.2006.10.011
Publication date: November 13, 2006
PMID: 17125854
Screening for ligands using a generic and high-throughput light-scattering-based assay.
Senisterra GA, Markin E, Yamazaki K, Hui R, Vedadi M, Awrey DE
J Biomol Screen 11(8):940-8 . doi: 10.1177/1087057106294699
Publication date: November 7, 2006
PMID: 17092916
Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Littler DR, Walker JR, She YM, Finerty PJ, Newman EM, Dhe-Paganon S
Biochem. Biophys. Res. Commun. 349(4):1182-9 . doi: 10.1016/j.bbrc.2006.08.160
Publication date: November 3, 2006
PMID: 16973127
Changes in sodium channel expression following trigeminal nerve injury.
Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM;
Experimental Neurology 202:207-216 . doi: 10.1016/j.expneurol.2006.05.035
Publication date: November 1, 2006
PMID: 16908020

October 2006

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM
Proc. Natl. Acad. Sci. U.S.A. 103(43):15835-40 . doi: 10.1073/pnas.0605224103
Publication date: October 24, 2006
PMID: 17035505
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.
Hardcastle, IR; Ahmed, SU; Atkins, H; Farnie, G; Golding, BT; Griffin, RJ; Guyenne, S; Hutton, C; Källblad, P; Kemp, SJ; Kitching, MS; Newell, DR; Norbedo, S; Northen, JS; Reid, RJ; Saravanan, K; Willems, HMG; Lunec, J;
Journal of Medicinal Chemistry 49:6209-6221 . doi: 10.1021/jm0601194
Publication date: October 18, 2006
PMID: 17034127
Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
Oppermann U
Endocr Metab Immune Disord Drug Targets 6(3):259-69 . doi:
Publication date: October 5, 2006
PMID: 17017977

September 2006

Pharmacological FMRI in the development of new analgesic compounds.
Schweinhardt, P; Bountra, C; Tracey, I;
NMR in Biomedicine 19:702-711 . doi: 10.1002/nbm.1076
Publication date: September 30, 2006
PMID: 16986120
Structural basis for molecular recognition and presentation of histone H3 by WDR5.
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J
EMBO J. 25(18):4245-52 . doi: 10.1038/sj.emboj.7601316
Publication date: September 20, 2006
PMID: 16946699
Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
Oppermann U.
Endocrine, metabolic & immune disorders drug targets 6(3):259-269 . doi: http://www.eurekaselect.com/77053/article
Publication date: September 1, 2006
PMID: 17017977
Development of an automated large-scale protein-crystallization and monitoring system for high-throughput protein-structure analyses.
Hiraki M, Kato R, Nagai M, Satoh T, Hirano S, Ihara K, Kudo N, Nagae M, Kobayashi M, Inoue M, Uejima T, Oda S, Chavas LM, Akutsu M, Yamada Y, Kawasaki M, Matsugaki N, Igarashi N, Suzuki M, Wakatsuki S.
Acta Crystallogr D Biol Crystallogr 62(Pt 9):1058-65 . doi: 10.1107/S0907444906023821
Publication date: September 1, 2006
PMID: 16929107
Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).
Dombrovski L, Dong A, Bochkarev A, Plotnikov AN
Proteins 64(4):1091-4 . doi: 10.1002/prot.21048
Publication date: September 1, 2006
PMID: 16804942

August 2006

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
Dunford, JE; Kavanagh, K; Oppermann, U; Ebetino, EH; Russell, RGG; Rogers, MJ;
Journal of Bone and Mineral Research 21:S396-S397 . doi:
Publication date: August 31, 2006
PMID:

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