Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain. Read more about Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain.
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Read more about Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. Read more about Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen. Read more about EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit. Read more about Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit.
Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex. Read more about Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex.
Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo. Read more about Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. Read more about Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.
PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase. Read more about PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase.
Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors. Read more about Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.
