Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit. Read more about Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit.
Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex. Read more about Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex.
Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo. Read more about Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. Read more about Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.
PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase. Read more about PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase.
Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors. Read more about Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.
Global Profiling of Acetyltransferase Feedback Regulation. Read more about Global Profiling of Acetyltransferase Feedback Regulation.
Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Read more about Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.
An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates. Read more about An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.
