Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. Read more about Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept.
Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. Read more about Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains.
Architecture of the native major royal jelly protein 1 oligomer. Read more about Architecture of the native major royal jelly protein 1 oligomer.
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Read more about The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export. Read more about BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.
Extending the Code of Sequence Readout by Gene Regulatory Proteins: The Role of Hoogsteen Base Pairing in p53-DNA Recognition. Read more about Extending the Code of Sequence Readout by Gene Regulatory Proteins: The Role of Hoogsteen Base Pairing in p53-DNA Recognition.
Guaiacol as a drug candidate for treating adult polyglucosan body disease. Read more about Guaiacol as a drug candidate for treating adult polyglucosan body disease.
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-based MDMX Inhibitors. Read more about Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-based MDMX Inhibitors.
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Read more about Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Read more about Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.
