Development, Optimization and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4-d]pyrrolo[2,3-b]pyridine Scaffold. Read more about Development, Optimization and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4-d]pyrrolo[2,3-b]pyridine Scaffold.
A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition. Read more about A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.
Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo. Read more about Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo.
Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes. Read more about Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes.
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. Read more about Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Read more about A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. Read more about Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. Read more about NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides. Read more about A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides.
