Therapeutics discovery: From bench to first in-human trials. Read more about Therapeutics discovery: From bench to first in-human trials.
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Read more about Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.
Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. Read more about Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces. Read more about Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces.
Halogen-aromatic π-interactions modulate inhibitor residence time. Read more about Halogen-aromatic π-interactions modulate inhibitor residence time.
Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities. Read more about Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.
Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Read more about Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms. Read more about A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms.
Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila. Read more about Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.
