Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Read more about Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B. Read more about The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B.
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus. Read more about Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus.
Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications. Read more about Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. Read more about Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant. Read more about An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant.
SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4. Read more about SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4.
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Read more about Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Read more about A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.
Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. Read more about Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting.
