Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors. Read more about Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Discovery of Nedd4 auto-ubiquitination inhibitors. Read more about Discovery of Nedd4 auto-ubiquitination inhibitors.
The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence. Read more about The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence.
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Read more about Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen. Read more about Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis. Read more about A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis.
Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity. Read more about Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity.
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition. Read more about Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Read more about Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Read more about DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
