High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin. Read more about High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.
Dual-site phosphorylation of SLX4 stabilizes the SLX4-MUS81 interface to promote mitotic SMX assembly and genome protection. Read more about Dual-site phosphorylation of SLX4 stabilizes the SLX4-MUS81 interface to promote mitotic SMX assembly and genome protection.
Comparison of CX-4945 and SGC-CK2-1 as inhibitors of CSNK2 using quantitative phosphoproteomics: Triple SILAC in combination with inhibitor-resistant CSNK2. Read more about Comparison of CX-4945 and SGC-CK2-1 as inhibitors of CSNK2 using quantitative phosphoproteomics: Triple SILAC in combination with inhibitor-resistant CSNK2.
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML. Read more about A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.
Rational discovery of therapeutic PAK1 allosteric activators. Read more about Rational discovery of therapeutic PAK1 allosteric activators.
Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ). Read more about Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ).
Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS). Read more about Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).
Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans. Read more about Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans.
Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants. Read more about Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants.
Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors. Read more about Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors.
