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Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library. Read more about Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library.
Structural Insights into the Auto-regulation and Cooperativity of the Human Transcription Factor Ets-2. Read more about Structural Insights into the Auto-regulation and Cooperativity of the Human Transcription Factor Ets-2.
The 9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain. Read more about The 9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain.
Building a roadmap for developing combination therapies for Alzheimer's disease. Read more about Building a roadmap for developing combination therapies for Alzheimer's disease.
Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. Read more about Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
Preclinical target validation using patient-derived cells. Read more about Preclinical target validation using patient-derived cells.
A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Read more about A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A. Read more about 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A.
Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a. Read more about Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.
