Building a roadmap for developing combination therapies for Alzheimer's disease. Read more about Building a roadmap for developing combination therapies for Alzheimer's disease.
Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. Read more about Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
Preclinical target validation using patient-derived cells. Read more about Preclinical target validation using patient-derived cells.
A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Read more about A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A. Read more about 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A.
Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a. Read more about Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.
Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8. Read more about Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Read more about K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B. Read more about Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B.
Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents. Read more about Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents.
