Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8. Read more about Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Read more about K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B. Read more about Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B.
Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents. Read more about Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents.
LLY-507, a Cell-Active, Potent and Selective Inhibitor of Protein Lysine Methyltransferase SMYD2. Read more about LLY-507, a Cell-Active, Potent and Selective Inhibitor of Protein Lysine Methyltransferase SMYD2.
Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures. Read more about Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures.
Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Read more about Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Read more about Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation.
Perspective on Computational and Structural Aspects of Kinase Discovery from IPK2014. Read more about Perspective on Computational and Structural Aspects of Kinase Discovery from IPK2014.
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Read more about LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
