LLY-507, a Cell-Active, Potent and Selective Inhibitor of Protein Lysine Methyltransferase SMYD2. Read more about LLY-507, a Cell-Active, Potent and Selective Inhibitor of Protein Lysine Methyltransferase SMYD2.
Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures. Read more about Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures.
Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Read more about Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Read more about Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation.
Perspective on Computational and Structural Aspects of Kinase Discovery from IPK2014. Read more about Perspective on Computational and Structural Aspects of Kinase Discovery from IPK2014.
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Read more about LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. Read more about Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation.
Discovery of a Dual PRMT5-PRMT7 Inhibitor. Read more about Discovery of a Dual PRMT5-PRMT7 Inhibitor.
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes. Read more about Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum. Read more about Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.
