Publications

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Displaying 201 - 250 of 2261

2020

October 2020

Expression Screening of Human Integral Membrane Proteins Using BacMam.
Mahajan P, Ellis K, Mukhopadhyay S, Fernandez-Cid A, Chi G, Man H, Dürr KL, Burgess-Brown NA
Methods Mol Biol 2199:95-115 . doi: 10.1007/978-1-0716-0892-0_6
Publication date: October 31, 2020
PMID: 33125646
Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells.
Mahajan P, Strain-Damerell C, Mukhopadhyay S, Fernandez-Cid A, Gileadi O, Burgess-Brown NA
Methods Mol Biol 2199:67-94 . doi: 10.1007/978-1-0716-0892-0_5
Publication date: October 31, 2020
PMID: 33125645
Screening and Production of Recombinant Human Proteins: Protein Production in E. coli.
Burgess-Brown NA, Mahajan P, Strain-Damerell C, Fernandez-Cid A, Gileadi O, Gräslund S
Methods Mol Biol 2199:45-66 . doi: 10.1007/978-1-0716-0892-0_4
Publication date: October 31, 2020
PMID: 33125644
Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning.
Strain-Damerell C, Mahajan P, Fernandez-Cid A, Gileadi O, Burgess-Brown NA
Methods Mol Biol 2199:23-43 . doi: 10.1007/978-1-0716-0892-0_3
Publication date: October 31, 2020
PMID: 33125643
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.
Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW
Front Mol Neurosci 13:538219 . doi: 10.3389/fnmol.2020.538219
Publication date: October 31, 2020
PMID: 33122997
Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.
Schröder M, Filippakopoulos P, Schwalm MP, Ferrer CA, Drewry DH, Knapp S, Chaikuad A
Int J Mol Sci 21(21): . doi: 10.3390/ijms21217953
Publication date: October 26, 2020
PMID: 33114754
RecQ helicases in DNA repair and cancer targets.
Newman JA, Gileadi O
Essays Biochem 64(5):819-830 . doi: 10.1042/EBC20200012
Publication date: October 26, 2020
PMID: 33095241
Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics.
Meijer I, Willems S, Ni X, Heering J, Chaikuad A, Merk D
Int J Mol Sci 21(21): . doi: 10.3390/ijms21217895
Publication date: October 24, 2020
PMID: 33114319
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB, Kavanagh J, Chau KK, Downs LO, Cox S, Dunn L, Justice A, Wareing S, Dingle K, Rudkin J, Auckland K, Fyfe A, Bolton J, Paton R, Mentzer AJ, Jeffery K, Andersson MI, James T, Peto TEA, Marsden BD, Screaton G, Cornall RJ, Klenerman P, Ebner D, Stuart DI, Crook DW, Stoesser N, Kennedy SH, Thompson C, Gupta S, Matthews PC
Euro Surveill 25(42): . doi: 10.2807/1560-7917.ES.2020.25.41.2001721
Publication date: October 24, 2020
PMID: 33094717
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, Von Delft F, Dowson CG, Spring DR
Chemical Science 11:10792-10801 . doi: 10.1039/d0sc01232g
Publication date: October 20, 2020
PMID:
Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation.
Elie J, Feizbakhsh O, Desban N, Josselin B, Baratte B, Bescond A, Duez J, Fant X, Bach S, Marie D, Place M, Ben Salah S, Chartier A, Berteina-Raboin S, Chaikuad A, Knapp S, Carles F, Bonnet P, Buron F, Routier S, Ruchaud S
J Enzyme Inhib Med Chem 35(1):1840-1853 . doi: 10.1080/14756366.2020.1825408
Publication date: October 13, 2020
PMID: 33040634
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.
Silva SF, Klippel AH, Ramos PZ, Santiago ADS, Valentini SR, Bengtson MH, Massirer KB, Bilsland E, Couñago RM, Zanelli CF
PLoS Negl Trop Dis 14(10):e0008762 . doi: 10.1371/journal.pntd.0008762
Publication date: October 12, 2020
PMID: 33044977
Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.
Álvarez-Coiradas E, Munteanu CR, Díaz-Sáez L, Pazos A, Huber KVM, Loza MI, Domínguez E
Int Immunopharmacol 89(Pt A):107026 . doi: 10.1016/j.intimp.2020.107026
Publication date: October 9, 2020
PMID: 33045560
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models.
Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, Glass M, Greig IR, Ross RA
Neuropsychopharmacology . doi: 10.1038/s41386-020-00876-5
Publication date: October 8, 2020
PMID: 33036015
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandão-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keserü GM, Klein HF, Martin MP, Noble MEM, O'Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA
Nat Commun 11(1):5047 . doi: 10.1038/s41467-020-18709-w
Publication date: October 7, 2020
PMID: 33028810
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Vilema-Enríquez G, Quinlan R, Kilfeather P, Mazzone R, Saqlain S, Del Molino Del Barrio I, Donato A, Corda G, Li F, Vedadi M, Németh AH, Brennan PE, Wade-Martins R
J Biol Chem . doi: 10.1074/jbc.RA120.015533
Publication date: October 7, 2020
PMID: 33028632
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandão-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keserü GM, Klein HF, Martin MP, Noble MEM, O’Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA
Nature Communications 11:5047- . doi: 10.1038/s41467-020-18709-w
Publication date: October 6, 2020
PMID: 33028810
Translational Control during Mammalian Neocortex Development and Postembryonic Neuronal Function.
Oliveira NCM, Lins ÉM, Massirer KB, Bengtson MH
Semin Cell Dev Biol . doi: 10.1016/j.semcdb.2020.09.006
Publication date: October 2, 2020
PMID: 33020045

September 2020

Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway.
Juettner NE, Bogen JP, Bauer TA, Knapp S, Pfeifer F, Huettenhain SH, Meusinger R, Kraemer A, Fuchsbauer HL
J. Nat. Prod. . doi: 10.1021/acs.jnatprod.0c00201
Publication date: September 30, 2020
PMID: 32998509
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020
Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB, Kavanagh J, Chau KK, Downs LO, Cox S, Dunn L, Justice A, Wareing S, Dingle K, Rudkin J, Auckland K, Fyfe A, Bolton J, Paton R, Mentzer AJ, Jeffery K, Andersson MI, James T, Peto TEA, Marsden BD, Screaton G, Cornall RJ, Klenerman P, Ebner D, Stuart DI, Crook DW, Stoesser N, Kennedy SH, Thompson C, Gupta S, Matthews PC
Eurosurveillance 25:- . doi: 10.2807/1560-7917.es.2020.25.41.2001721
Publication date: September 30, 2020
PMID: 33094717
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S, Wolf E
Nat. Chem. Biol. . doi: 10.1038/s41589-020-00652-y
Publication date: September 28, 2020
PMID: 32989298
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor.
Tamir TY, Drewry DH, Wells C, Major MB, Axtman AD
Sci Rep 10(1):15826 . doi: 10.1038/s41598-020-72869-9
Publication date: September 28, 2020
PMID: 32985588
Structural and functional diversity calls for a new classification of ABC transporters.
Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinket HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R
FEBS Lett. . doi: 10.1002/1873-3468.13935
Publication date: September 26, 2020
PMID: 32978974
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
Ainsworth M, Andersson M, Auckland K, Baillie JK, Barnes E, Beer S, Beveridge A, Bibi S, Blackwell L, Borak M, Bown A, Brooks T, Burgess-Brown NA, Camara S, Catton M, Chau KK, Christott T, Clutterbuck E, Coker J, Cornall RJ, Cox S, Crawford-Jones D, Crook DW, D'Arcangelo S, Dejnirattsai W, Dequaire JMM, Dimitriadis S, Dingle KE, Doherty G, Dold C, Dong T, Dunachie SJ, Ebner D, Emmenegger M, Espinosa A, Eyre DW, Fairhead R, Fassih S, Feehily C, Felle S, Fernandez-Cid A, Fernandez Mendoza M, Foord TH, Fordwoh T, Fox McKee D, Frater J, Gallardo Sanchez V, Gent N, Georgiou D, Groves CJ, Hallis B, Hammond PM, Hatch SB, Harvala HJ, Hill J, Hoosdally SJ, Horsington B, Howarth A, James T, Jeffery K, Jones E, Justice A, Karpe F, Kavanagh J, Kim DS, Kirton R, Klenerman P, Knight JC, Koukouflis L, Kwok A, Leuschner U, Levin R, Linder A, Lockett T, Lumley SF, Marinou S, Marsden BD, Martinez J, Martins Ferreira L, Mason L, Matthews PC, Mentzer AJ, Mobbs A, Mongkolsapaya J, Morrow J, Mukhopadhyay SMM, Neville MJ, Oakley S, Oliveira M, Otter A, Paddon K, Pascoe J, Peng Y, Perez E, Perumal PK, Peto TEA, Pickford H, Ploeg RJ, Pollard AJ, Richardson A, Ritter TG, Roberts DJ, Rodger G, Rollier CS, Rowe C, Rudkin JK, Screaton G, Semple MG, Sienkiewicz A, Silva-Reyes L, Skelly DT, Sobrino Diaz A, Stafford L, Stockdale L, Stoesser N, Street T, Stuart DI, Sweed A, Taylor A, Thraves H, Tsang HP, Verheul MK, Vipond R, Walker TM, Wareing S, Warren Y, Wells C, Wilson C, Withycombe K, Young RK
The Lancet Infectious Diseases . doi: 10.1016/s1473-3099(20)30634-4
Publication date: September 22, 2020
PMID: 32979318
Concise, gram-scale synthesis of furo[2,3-b]pyridines with functional handles for chemoselective cross-coupling.
O'Byrne SN, Eduful BJ, Willson TM, Drewry DH
Tetrahedron Lett 61(38): . doi: 10.1016/j.tetlet.2020.152353
Publication date: September 17, 2020
PMID: 33012852
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.
Schuhmacher MK, Beldar S, Khella MS, Bröhm A, Ludwig J, Tempel W, Weirich S, Min J, Jeltsch A
Commun Biol 3(1):511 . doi: 10.1038/s42003-020-01223-6
Publication date: September 16, 2020
PMID: 32939018
NeuroChat with Research Assistant Professor Alison Axtman.
Lindsley CW, Axtman AD
ACS Chem Neurosci 11(18):2783-2785 . doi: 10.1021/acschemneuro.0c00548
Publication date: September 16, 2020
PMID: 32933260
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ
Sci Adv 6(37): . doi: 10.1126/sciadv.abc0367
Publication date: September 13, 2020
PMID: 32917713
Nanopore Enzymology to Study Protein Kinases and Their Inhibition by Small Molecules.
Harrington L, Alexander LT, Knapp S, Bayley H
Methods Mol. Biol. 2186:95-114 . doi: 10.1007/978-1-0716-0806-7_8
Publication date: September 13, 2020
PMID: 32918732
What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?
Edwards A
J Chem Inf Model . doi: 10.1021/acs.jcim.0c00861
Publication date: September 11, 2020
PMID: 32914973
Ten simple rules for open human health research.
Bafeta A, Bobe J, Clucas J, Gonsalves PP, Gruson-Daniel C, Hudson KL, Klein A, Krishnakumar A, McCollister-Slipp A, Lindner AB, Misevic D, Naslund JA, Nebeker C, Nikolaidis A, Pasquetto I, Sanchez G, Schapira M, Scheininger T, Schoeller F, Sólon Heinsfeld A, Taddei F
PLoS Comput. Biol. 16(9):e1007846 . doi: 10.1371/journal.pcbi.1007846
Publication date: September 4, 2020
PMID: 32881878
Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.
Dong C, Nakagawa R, Oyama K, Yamamoto Y, Zhang W, Dong A, Li Y, Yoshimura Y, Kamiya H, Nakayama JI, Ueda J, Min J
Elife 9: . doi: 10.7554/eLife.58675
Publication date: September 1, 2020
PMID: 32869745
TargetDB: A target information aggregation tool and tractability predictor
De Cesco S, Davis JB, Brennan PE
PLOS ONE 15:e0232644-e0232644 . doi: 10.1371/journal.pone.0232644
Publication date: September 1, 2020
PMID: 32877430

August 2020

Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death.
Cottone L, Cribbs AP, Khandelwal G, Wells G, Ligammari L, Philpott M, Tumber A, Lombard P, Hookway ES, Szommer T, Johansson C, Brennan PE, Pillay N, Jenner RG, Oppermann U, Flanagan AM
Cancer Res. . doi: 10.1158/0008-5472.CAN-20-1387
Publication date: August 27, 2020
PMID: 32855205
Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.
Quevedo CE, Bataille CJR, Byrne S, Durbin M, Elkins J, Guillermo A, Jones AM, Knapp S, Nadali A, Walker RG, Wilkinson IVL, Wynne GM, Davies SG, Russell AJ
Bioorg Med Chem 28(22):115724 . doi: 10.1016/j.bmc.2020.115724
Publication date: August 26, 2020
PMID: 33128909
Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death
Cottone L, Cribbs AP, Khandelwal G, Wells G, Ligammari L, Philpott M, Tumber A, Lombard P, Hookway ES, Szommer T, Johansson C, Brennan PE, Pillay N, Jenner RG, Oppermann U, Flanagan AM
Cancer Research 80:4540-4551 . doi: 10.1158/0008-5472.can-20-1387
Publication date: August 26, 2020
PMID: 32855205
Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.
Krämer A, Kurz CG, Berger BT, Celik IE, Tjaden A, Greco FA, Knapp S, Hanke T
Eur J Med Chem 208:112770 . doi: 10.1016/j.ejmech.2020.112770
Publication date: August 23, 2020
PMID: 32883634
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.
Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, Haight J, Tonekaboni SAM, Fortier AM, Kuasne H, McKee TD, Mahmoud H, Kushida M, Cameron S, Dogan-Artun N, Chen W, Nie Y, Zhang LX, Vellanki RN, Zhou S, Prinos P, Wouters BG, Dirks PB, Done SJ, Park M, Cescon DW, Haibe-Kains B, Lupien M, Arrowsmith CH
Nat Commun 11(1):4205 . doi: 10.1038/s41467-020-18020-8
Publication date: August 21, 2020
PMID: 32826891
Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S
Eur J Med Chem 208:112721 . doi: 10.1016/j.ejmech.2020.112721
Publication date: August 20, 2020
PMID: 33035818
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study
Eyre DW, Lumley SF, O'Donnell D, Campbell M, Sims E, Lawson E, Warren F, James T, Cox S, Howarth A, Doherty G, Hatch SB, Kavanagh J, Chau KK, Fowler PW, Swann J, Volk D, Yang-Turner F, Stoesser N, Matthews PC, Dudareva M, Davies T, Shaw RH, Peto L, Downs LO, Vogt A, Amini A, Young BC, Drennan PG, Mentzer AJ, Skelly DT, Karpe F, Neville MJ, Andersson M, Brent AJ, Jones N, Martins Ferreira L, Christott T, Marsden BD, Hoosdally S, Cornall R, Crook DW, Stuart DI, Screaton G, Watson AJR, Taylor A, Chetwynd A, Grassam-Rowe A, Mighiu AS, Livingstone A, Killen A, Rigler C, Harries C, East C, Lee C, Mason CJB, Holland C, Thompson C, Hennesey C, Savva C, Kim DS, Harris EWA, McGivern EJ, Qian E, Rothwell E, Back F, Kelly G, Watson G, Howgego G, Chase H, Danbury H, Laurenson-Schafer H, Ward HL, Hendron H, Vorley IC, Tol I, Gunnell J, Ward JLF, Drake J, Wilson JD, Morton J, Dequaire J, O'Byrne K, Motohashi K, Harper K, Ravi K, Millar LJ, Peck LJ, Oliver M, English MR, Kumarendran M, Wedlich M, Ambler O, Deal OT, Sweeney O, Cowie P, Naudé RTW, Young R, Freer R, Scott S, Sussmes S, Peters S, Pattenden S, Waite S, Johnson SA, Kourdov S, Santos-Paulo S, Dimitrov S, Kerneis S, Ahmed-Firani T, King TB, Ritter TG, Foord TH, De Toledo Z, Christie T, Gergely B, Axten D, Simons E-J, Nevard H, Philips J, Szczurkowska J, Patel K, Smit K, Warren L, Morgan L, Smith L, Robles M, McKnight M, Luciw M, Gates M, Sande N, Turford R, Ray R, Rughani S, Mitchell T, Bellinger T, Wharton V, Justice A, Jesuthasan G, Wareing S, Huda Mohamad Fadzillah N, Cann K, Kirton R, Sutton C, Salvagno C, DAmato G, Pill G, Butcher L, Rylance-Knight L, Tabirao M, Moroney R, Wright S, Peto TEA, Holthof B, O'Donnell A-M, Ebner D, Conlon CP, Jeffery K, Walker TM
eLife 9:1-37 . doi: 10.7554/elife.60675
Publication date: August 20, 2020
PMID: 32820721
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction
Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE
Nature vol. 588,7837 (2020): 344-349 . doi: 10.1038/s41586-020-2673-2
Publication date: August 19, 2020
PMID: 32814344
Deliberately Losing Control of C-H Activation Processes in the Design of Small Molecule Fragment Arrays Targeting Peroxisomal Metabolism.
Kahn Tareque R, Hassell-Hart S, Krojer T, Bradley A, Velupillai S, Talon R, Fairhead M, Day IJ, Bala K, Felix R, Kemmitt P, Brennan P, von Delft F, Díaz Sáez L, Spencer J, Huber K
ChemMedChem . doi: 10.1002/cmdc.202000543
Publication date: August 18, 2020
PMID: 32812371
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.
Matossian MD, Burks HE, Elliott S, Hoang VT, Zuercher WJ, Wells C, Drewry DH, Kapadia N, Chang T, Yan T, Windsor GO, Nguyen K, Fang F, Nephew KP, Buechlein A, Rusch DB, Sabol RA, Ucar DA, Zabaleta J, Miele L, Bunnell BA, Collins-Burow BM, Burow ME
Anticancer Drugs 31(8):759-775 . doi: 10.1097/CAD.0000000000000962
Publication date: August 17, 2020
PMID: 32796402
Deliberately Losing Control of C−H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism
Khan Tareque R, Hassell-Hart S, Krojer T, Bradley A, Velupillai S, Talon R, Fairhead M, Day IJ, Bala K, Felix R, Kemmitt PD, Brennan P, von Delft F, Díaz Sáez L, Huber K, Spencer J
ChemMedChem . doi: 10.1002/cmdc.202000543
Publication date: August 17, 2020
PMID: 32812371
Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines.
Saul S, Pu SY, Zuercher WJ, Einav S, Asquith CRM
Bioorg. Med. Chem. Lett. 30(16):127284 . doi: 10.1016/j.bmcl.2020.127284
Publication date: August 15, 2020
PMID: 32631507
Generation and validation of recombinant antibodies to study human aminoacyl tRNA synthetases.
Preger C, Wigren E, Ossipova E, Marks C, Lengqvist J, Hofström C, Andersson O, Jakobsson PJ, Gräslund S, Persson H
J. Biol. Chem. . doi: 10.1074/jbc.RA120.012893
Publication date: August 14, 2020
PMID: 32817337
Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4.
Preuss F, Chatterjee D, Mathea S, Shrestha S, St-Germain J, Saha M, Kannan N, Raught B, Rottapel R, Knapp S
Structure . doi: 10.1016/j.str.2020.07.016
Publication date: August 13, 2020
PMID: 32814032
Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.
Henderson SH, Sorrell F, Bennett J, Hanley MT, Robinson S, Hopkins Navratilova I, Elkins JM, Ward SE
ACS Med Chem Lett 11(8):1620-1626 . doi: 10.1021/acsmedchemlett.0c00279
Publication date: August 13, 2020
PMID: 32832032
DFG-1 residue controls inhibitor binding mode and affinity providing a basis for rational design of kinase inhibitor selectivity.
Schröder M, Bullock AN, Fedorov O, Bracher F, Chaikuad A, Knapp S
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00898
Publication date: August 12, 2020
PMID: 32787076
Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
Smil D, Wong JF, Williams E, Adamson R, Howarth A, McLeod D, Mamai A, Kim S, Wilson B, Kiyota T, Aman A, Owen J, Poda G, Horiuchi K, Kuznetsova E, Ma H, Hamblin JN, Cramp S, Roberts O, Edwards AM, Uehling D, Al-Awar R, Bullock AN, O'Meara J, Isaac M
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c01199
Publication date: August 11, 2020
PMID: 32787083

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