Publications

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Displaying 201 - 250 of 2162

2020

June 2020

Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs).
Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV
Endocr. Relat. Cancer . doi: 10.1530/ERC-20-0127
Publication date: June 1, 2020
PMID: 32590358
Quantifying CDK inhibitor selectivity in live cells
Wells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang B, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB
Nature Communications 11:2743- . doi: 10.1038/s41467-020-16559-0
Publication date: June 1, 2020
PMID: 32488087

May 2020

Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs)
Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV
Endocrine-related cancer 27:R345-R355 . doi: 10.1530/ERC-20-0127
Publication date: May 31, 2020
PMID: 32590358
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M
Life Sci Alliance 3(7): . doi: 10.26508/lsa.202000725
Publication date: May 30, 2020
PMID: 32467316
Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases.
Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD
ACS Chem Neurosci . doi: 10.1021/acschemneuro.0c00176
Publication date: May 28, 2020
PMID: 32464049
Bioisosteric Replacement of Arylamide-linked Spine Residues by N-Acylhydrazones and Selenophenes as Design Strategy to Novel Dibenzosuberone Derivatives as Type I½ p38 MAP Kinase Inhibitors.
Galvez Bulh Otilde Es Pedreira JUL, Nahidino P, Kudolo M, Pantsar T, Berger BT, Forster M, Knapp S, Laufer SA, Barreiro EJ
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00508
Publication date: May 28, 2020
PMID: 32462866
HighVia-A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity.
Howarth A, Schröder M, Montenegro RC, Drewry DH, Heba S, Millar V, Müller S, Ebner DV
SLAS Discov 2472555220923979 . doi: 10.1177/2472555220923979
Publication date: May 27, 2020
PMID: 32458721
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
KROJER T, Douangamath A, Fearon D, Gehrtz P, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandaõ-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, FAIRHEAD M, Firth JD, Jones P, Keely A, Keserü GM, Klein HF, Martin MP, Noble MEM, O’Brien P, Powell A, Reddi R, Skyner R, Snee M, Waring MJ, Wild C, London N, VON DELFT F, Walsh ME
biorxiv . doi: 10.1101/2020.05.27.118117
Publication date: May 26, 2020
PMID:
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J
Cell Chem Biol . doi: 10.1016/j.chembiol.2020.05.007
Publication date: May 26, 2020
PMID: 32470319
Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini G, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaia V, Morgan J, Sorrell F, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers S, Cheetham S, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S
J. Med. Chem. . doi: 10.1021/acs.jmedchem.9b01803
Publication date: May 20, 2020
PMID: 32433887
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD
Cell . doi: 10.1016/j.cell.2020.04.047
Publication date: May 20, 2020
PMID: 32445698
Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response.
Barreto P, Miguez Couñago R, Arruda P
Mitochondrion . doi: 10.1016/j.mito.2020.05.001
Publication date: May 18, 2020
PMID: 32439620
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD
Eur J Med Chem 200:112417 . doi: 10.1016/j.ejmech.2020.112417
Publication date: May 15, 2020
PMID: 32505849
Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer.
Baguña Torres J, Mosley M, Koustoulidou S, Hopkins S, Knapp S, Chaikuad A, Kondoh M, Tachibana K, Kersemans V, Cornelissen B
J. Nucl. Med. . doi: 10.2967/jnumed.120.243113
Publication date: May 15, 2020
PMID: 32414951
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy D
Nat Commun 11(1):2396 . doi: 10.1038/s41467-020-16271-z
Publication date: May 14, 2020
PMID: 32409666
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, von Delft F, Dowson CG, Spring DR
Chem Sci 11(39):10792-10801 . doi: 10.1039/d0sc01232g
Publication date: May 14, 2020
PMID: 34094333
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD
European Journal of Medicinal Chemistry 200:112417- . doi: 10.1016/j.ejmech.2020.112417
Publication date: May 14, 2020
PMID: 32505849
GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.
Foley AR, Zou Y, Dunford JE, Rooney J, Chandra G, Xiong H, Straub V, Voit T, Romero N, Donkervoort S, Hu Y, Markello T, Horn A, Qebibo L, Dastgir J, Meilleur K, Finkel RS, Fan Y, Mamchaoui K, Duguez S, Nelson I, Laporte J, Santi M, Malfatti E, Maisonobe T, Touraine P, Hirano M, Hughes I, Bushby K, Oppermann U, Böhm J, Jaiswal JK, Stojkovic T, Bönnemann CG
Ann. Neurol. . doi: 10.1002/ana.25772
Publication date: May 13, 2020
PMID: 32403198
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00395
Publication date: May 5, 2020
PMID: 32369358
Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.
Shen Y, Li F, Szewczyk MM, Halabelian L, Park KS, Chau I, Dong A, Zeng H, Chen H, Meng F, Barsyte-Lovejoy D, Arrowsmith CH, Brown P, Liu J, Vedadi M, Jin J
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00406
Publication date: May 5, 2020
PMID: 32367723
Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.
Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Müller S, Siveke JT
Oncogene . doi: 10.1038/s41388-020-1301-9
Publication date: May 4, 2020
PMID: 32366905
L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ.
Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D
J. Med. Chem. . doi: 10.1021/acs.jmedchem.9b02150
Publication date: May 1, 2020
PMID: 32356658

April 2020

A lower X-gate in TASK channels traps inhibitors within the vestibule.
Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N, Carpenter EP
Nature . doi: 10.1038/s41586-020-2250-8
Publication date: April 29, 2020
PMID: 32499642
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.
Ketley A, Wojciechowska M, Ghidelli-Disse S, Bamborough P, Ghosh TK, Morato ML, Sedehizadeh S, Malik NA, Tang Z, Powalowska P, Tanner M, Billeter-Clark R, Trueman RC, Geiszler PC, Agostini A, Othman O, Bösche M, Bantscheff M, Rüdiger M, Mossakowska DE, Drewry DH, Zuercher WJ, Thornton CA, Drewes G, Uings I, Hayes CJ, Brook JD
Sci Transl Med 12(541): . doi: 10.1126/scitranslmed.aaz2415
Publication date: April 29, 2020
PMID: 32350131
A lower X-gate in TASK channels traps inhibitors within the vestibule
RODSTROM K, Kiper A, Zhang W, Rinne S, PIKE A, Goldstein M, Conrad L, Delbeck M, Hahn M, Meier H, Platzk M, Quigley A, Speedman D, SHRESTHA L, Mukhopadhyay S, BURGESS-BROWN N, TUCKER S, Mueller T, Decher N, CARPENTER E
Nature 582:443-447 . doi: 10.1038/s41586-020-2250-8
Publication date: April 28, 2020
PMID: 32499642
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.
Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L
Elife 9: . doi: 10.7554/eLife.47333
Publication date: April 16, 2020
PMID: 32297856
Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding.
Aquino B, da Silva VCH, Massirer KB, Arruda P
BMC Plant Biol. 20(1):158 . doi: 10.1186/s12870-020-2328-3
Publication date: April 15, 2020
PMID: 32293271
Targeting der kleinen GTPasen über ihre regulatorischen Proteine
Gray JL, Delft F, Brennan PE
Angewandte Chemie 132:6402-6428 . doi: 10.1002/ange.201900585
Publication date: April 15, 2020
PMID:
Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer
Scott F, Fala AM, Pennicott LE, Reuillon TD, Massirer KB, Elkins JM, Ward SE
Bioorganic and Medicinal Chemistry Letters 30:127040- . doi: 10.1016/j.bmcl.2020.127040
Publication date: April 14, 2020
PMID: 32085971
Importance of Quantifying Drug-Target Engagement in Cells.
Stefaniak J, Huber KVM
ACS Med Chem Lett 11(4):403-406 . doi: 10.1021/acsmedchemlett.9b00570
Publication date: April 9, 2020
PMID: 32292539
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).
Asquith CRM, Laitinen T, Wells CI, Tizzard GJ, Zuercher WJ
Molecules 25(7): . doi: 10.3390/molecules25071697
Publication date: April 7, 2020
PMID: 32272798
The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, Goldmann U, Gürtl B, Klavins K, Klimek C, Lindinger S, Liñeiro-Retes E, Müller AC, Onstein S, Redinger G, Reil D, Sedlyarov V, Wolf G, Crawford M, Everley R, Hepworth D, Liu S, Noell S, Piotrowski M, Stanton R, Zhang H, Corallino S, Faedo A, Insidioso M, Maresca G, Redaelli L, Sassone F, Scarabottolo L, Stucchi M, Tarroni P, Tremolada S, Batoulis H, Becker A, Bender E, Chang YN, Ehrmann A, Müller-Fahrnow A, Pütter V, Zindel D, Hamilton B, Lenter M, Santacruz D, Viollet C, Whitehurst C, Johnsson K, Leippe P, Baumgarten B, Chang L, Ibig Y, Pfeifer M, Reinhardt J, Schönbett J, Selzer P, Seuwen K, Bettembourg C, Biton B, Czech J, de Foucauld H, Didier M, Licher T, Mikol V, Pommereau A, Puech F, Yaligara V, Edwards A, Bongers BJ, Heitman LH, IJzerman AP, Sijben HJ, van Westen GJP, Grixti J, Kell DB, Mughal F, Swainston N, Wright-Muelas M, Bohstedt T, Burgess-Brown N, Carpenter L, Dürr K, Hansen J, Scacioc A, Banci G, Colas C, Digles D, Ecker G, Füzi B, Gamsjäger V, Grandits M, Martini R, Troger F, Altermatt P, Doucerain C, Dürrenberger F, Manolova V, Steck AL, Sundström H, Wilhelm M, Steppan CM
Nat Rev Drug Discov . doi: 10.1038/d41573-020-00056-6
Publication date: April 7, 2020
PMID: 32265506
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
Curran PR, Radoux CJ, Smilova MD, Sykes RA, Higueruelo AP, Bradley AR, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC
Journal of chemical information and modeling 60:1911-1916 . doi: 10.1021/acs.jcim.9b00996
Publication date: April 1, 2020
PMID: 32207937

March 2020

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.
Curran PR, Radoux C, Smilova MD, Sykes R, Higueruelo A, Bradley A, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC
J Chem Inf Model . doi: 10.1021/acs.jcim.9b00996
Publication date: March 24, 2020
PMID: 32207937
Quantifying Target Occupancy of Small Molecules within Living Cells
Robers MB, Friedman-Ohana R, Huber KVM, Huber KVM, Kilpatrick L, Kilpatrick L, Vasta JD, Berger BT, Chaudhry C, Hill S, Hill S, Müller S, Müller S, Knapp S, Knapp S, Knapp S, Knapp S, Wood KV, Wood KV
Annual Review of Biochemistry 89:557-581 . doi: 10.1146/annurev-biochem-011420-092302
Publication date: March 24, 2020
PMID: 32208767
Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.
Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J, Min J
Cell Rep 30(12):3996-4002.e4 . doi: 10.1016/j.celrep.2020.03.003
Publication date: March 24, 2020
PMID: 32209463
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, Fersht AR, Spencer J, Joerger AC
ACS Chem Biol 15(3):657-668 . doi: 10.1021/acschembio.9b00748
Publication date: March 20, 2020
PMID: 31990523
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.
Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller-Knapp S, Knapp S
ACS Chem. Biol. . doi: 10.1021/acschembio.0c00076
Publication date: March 16, 2020
PMID: 32176847
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman AD
ACS Med Chem Lett 11(3):340-345 . doi: 10.1021/acsmedchemlett.9b00399
Publication date: March 12, 2020
PMID: 32184967
Importance of Quantifying Drug-Target Engagement in Cells
Stefaniak J, Huber KVM
ACS Medicinal Chemistry Letters 11:403-406 . doi: 10.1021/acsmedchemlett.9b00570
Publication date: March 6, 2020
PMID: 32292539
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW
Cancer Cell 37:308-323.e12 . doi: 10.1016/j.ccell.2020.02.002
Publication date: March 5, 2020
PMID: 32142668
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Cribbs AP, Terlecki-Zaniewicz S, Philpott M, Baardman J, Ahern D, Lindow M, Obad S, Oerum H, Sampey B, Mander PK, Penn H, Wordsworth P, Bowness P, de Winther M, Prinjha RK, Feldmann M, Oppermann U
Proc. Natl. Acad. Sci. U.S.A. . doi: 10.1073/pnas.1919893117
Publication date: March 2, 2020
PMID: 32123118
Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding
Stach L, Morgan RM, Makhlouf L, Douangamath A, von Delft F, Zhang X, Freemont PS
FEBS Letters 594:933-943 . doi: 10.1002/1873-3468.13667
Publication date: March 1, 2020
PMID: 31701538
Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells
LINES K, FILIPPAKOPOULOS P, STEVENSON M, Lockstone H, WRIGHT B, BUCK D, BOUNTRA C, THAKKER RV
Endocrine-Related Cancer 27:163-174 . doi: 10.1530/ERC-19-0448
Publication date: March 1, 2020
PMID: 31935194

February 2020

Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.
Ward JA, Pinto-Fernandez A, Cornelissen L, Bonham S, Díaz-Sáez L, Riant O, Huber KVM, Kessler BM, Feron O, Tate EW
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00144
Publication date: February 28, 2020
PMID: 32109059
Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs
WARD JA, PINTO FERNANDEZ A, Cornelissen L, BONHAM S, DIAZ SAEZ L, Riant O, HUBER KVM, KESSLER BM, Feron O, Tate EW
Journal of Medicinal Chemistry 63:3756-3762 . doi: 10.1021/acs.jmedchem.0c00144
Publication date: February 28, 2020
PMID:
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.
Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW
Cancer Cell . doi: 10.1016/j.ccell.2020.02.002
Publication date: February 21, 2020
PMID: 32142668
Structure-based view of the druggable genome.
Wang J, Yazdani S, Han A, Schapira M
Drug Discov. Today . doi: 10.1016/j.drudis.2020.02.006
Publication date: February 19, 2020
PMID: 32084498
Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.
Scott F, Fala AM, Pennicott LE, Reuillon TD, Massirer KB, Elkins JM, Ward SE
Bioorg. Med. Chem. Lett. 127040 . doi: 10.1016/j.bmcl.2020.127040
Publication date: February 17, 2020
PMID: 32085971
MichelaNglo: sculpting protein views on web pages without coding
Ferla MP, Pagnamenta AT, Damerell D, Taylor JC, Marsden BD
Bioinformatics 36:3268-3270 . doi: 10.1093/bioinformatics/btaa104
Publication date: February 15, 2020
PMID: 32061125

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