Publications

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Displaying 101 - 150 of 2162

2020

December 2020

Identification of lysine isobutyrylation as a new histone modification mark.
Zhu Z, Han Z, Halabelian L, Yang X, Ding J, Zhang N, Ngo L, Song J, Zeng H, He M, Zhao Y, Arrowsmith CH, Luo M, Bartlett MG, Zheng YG
Nucleic Acids Res . doi: 10.1093/nar/gkaa1176
Publication date: December 11, 2020
PMID: 33313896
Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.
Wanior M, Preuss F, Ni X, Krämer A, Mathea S, Göbel T, Heidenreich D, Simonyi S, Kahnt AS, Joerger AC, Knapp S
J Med Chem 63(23):14680-14699 . doi: 10.1021/acs.jmedchem.0c01242
Publication date: December 10, 2020
PMID: 33216538
Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.
Forster M, Liang XJ, Schröder M, Gerstenecker S, Chaikuad A, Knapp S, Laufer S, Gehringer M
Int J Mol Sci 21(23): . doi: 10.3390/ijms21239269
Publication date: December 4, 2020
PMID: 33291717
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.
Doffe F, Carbonnier V, Tissier M, Leroy B, Martins I, Mattsson JSM, Micke P, Pavlova S, Pospisilova S, Smardova J, Joerger AC, Wiman KG, Kroemer G, Soussi T
Cell Death Differ 28(5):1477-1492 . doi: 10.1038/s41418-020-00672-0
Publication date: December 2, 2020
PMID: 33257846
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions
Sieberts SK, Perumal TM, Carrasquillo MM, Allen M, Reddy JS, Hoffman GE, Dang KK, Calley J, Ebert PJ, Eddy J, Wang X, Greenwood AK, Mostafavi S, Akbarian S, Bendl J, Breen MS, Brennand K, Brown L, Browne A, Buxbaum JD, Charney A, Chess A, Couto L, Crawford G, Devillers O, Devlin B, Dobbyn A, Domenici E, Filosi M, Flatow E, Francoeur N, Fullard J, Gil SE, Girdhar K, Gulyás-Kovács A, Gur R, Hahn CG, Haroutunian V, Hauberg ME, Huckins L, Jacobov R, Jiang Y, Johnson JS, Kassim B, Kim Y, Klei L, Kramer R, Lauria M, Lehner T, Lewis DA, Lipska BK, Montgomery K, Park R, Rosenbluh C, Roussos P, Ruderfer DM, Senthil G, Shah HR, Sloofman L, Song L, Stahl E, Sullivan P, Visintainer R, Wang J, Wang YC, Wiseman J, Xia E, Zhang W, Zharovsky E, Addis L, Addo SN, Airey DC, Arnold M, Bennett DA, Bi Y, Biber K, Blach C, Bradhsaw E, Brennan P, Canet-Aviles R, Cao S, Cavalla A, Chae Y, Chen WW, Cheng J, Collier DA, Dage JL, Dammer EB, Davis JW, Davis J, Drake D, Duong D, Eastwood BJ, Ehrlich M, Ellingson B, Engelmann BW, Esmaeelinieh S, Felsky D, Funk C, Gaiteri C
Scientific Data 7:- . doi: 10.1038/s41597-020-00642-8
Publication date: December 1, 2020
PMID: 33046718
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Baker LM, Aimon A, Murray JB, Surgenor AE, Matassova N, Roughley SD, Collins PM, Krojer T, von Delft F, Hubbard RE
Communications Chemistry 3:- . doi: 10.1038/s42004-020-00367-0
Publication date: December 1, 2020
PMID:

November 2020

BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy.
Segatto M, Szokoll R, Fittipaldi R, Bottino C, Nevi L, Mamchaoui K, Filippakopoulos P, Caretti G
Nat Commun 11(1):6108 . doi: 10.1038/s41467-020-19839-x
Publication date: November 30, 2020
PMID: 33257646
A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks.
Bassi G, Favalli N, Vuk M, Catalano M, Martinelli A, Trenner A, Porro A, Yang S, Tham CL, Moroglu M, Yue WW, Conway SJ, Vogt PK, Sartori AA, Scheuermann J, Neri D
Adv Sci (Weinh) 7(22):2001970 . doi: 10.1002/advs.202001970
Publication date: November 27, 2020
PMID: 33240760
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, Aimon A, Bennett JM, Neto JB, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs M, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, Jura N, Ashworth A, Irwin J, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I
bioRxiv . doi: 10.1101/2020.11.24.393405
Publication date: November 24, 2020
PMID: 33269349
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado A, Chaikuad A, Wells CI, Shrestha S, Zuercher WJ, Pickett JE, Kwarcinski FE, Sinha P, de Silva CS, Zutshi R, Liu S, Kannan N, Knapp S, Drewry DH, Willson TM
J Med Chem . doi: 10.1021/acs.jmedchem.0c01174
Publication date: November 20, 2020
PMID: 33215924
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system.
Chen J, Lippo L, Labella R, Tan SL, Marsden BD, Dustin ML, Ramasamy SK, Kusumbe AP
EMBO J e105242 . doi: 10.15252/embj.2020105242
Publication date: November 20, 2020
PMID: 33215738
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity
Pinto-Fernandez A, SALIO M, PARTRIDGE T, Chen J, Vere G, Greenwood H, Olie CS, DAMIANOU A, SCOTT HC, Pegg J, Chiarenza A, Diaz-Saez L, SMITH P, GONZALEZ-LOPEZ C, Patel B, Jones N, Hammonds T, HUBER K, MUSCHEL R, BORROW P, CERUNDOLO V, KESSLER B
British Journal of Cancer . doi: 10.1038/s41416-020-01167-y
Publication date: November 20, 2020
PMID: 33214684
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system
Chen J, Lippo L, Labella R, Tan SL, Marsden BD, Dustin ML, Ramasamy SK, Kusumbe AP
EMBO Journal :e105242- . doi: 10.15252/embj.2020105242
Publication date: November 20, 2020
PMID: 33215738
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Newman JA, Gavard AE, Lieb S, Ravichandran MC, Hauer K, Werni P, Geist L, Böttcher J, Engen JR, Rumpel K, Samwer M, Petronczki M, Gileadi O
Life Sci Alliance 4(1): . doi: 10.26508/lsa.202000795
Publication date: November 18, 2020
PMID: 33199508
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Ren H, Bakas NA, Vamos M, Chaikuad A, Limpert AS, Wimer CD, Brun SN, Lambert LJ, Tautz L, Celeridad M, Sheffler DJ, Knapp S, Shaw RJ, Cosford NDP
J Med Chem . doi: 10.1021/acs.jmedchem.0c00873
Publication date: November 17, 2020
PMID: 33200929
Epigenetic Mechanisms in Canine Cancer.
Xavier PLP, Müller S, Fukumasu H
Front Oncol 10:591843 . doi: 10.3389/fonc.2020.591843
Publication date: November 17, 2020
PMID: 33194754
Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers.
Conway SJ, Arimondo P, Arrowsmith C, Jin J, Luo C, Meanwell N, Young W, Georg G, Wang S
J Med Chem 63(21):12129-12130 . doi: 10.1021/acs.jmedchem.0c01748
Publication date: November 12, 2020
PMID: 33090784
Discovery of allosteric binding sites by crystallographic fragment screening.
Krojer T, Fraser JS, von Delft F
Curr Opin Struct Biol 65:209-216 . doi: 10.1016/j.sbi.2020.08.004
Publication date: November 11, 2020
PMID: 33171388
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, Merk D
Int J Mol Sci 21(22): . doi: 10.3390/ijms21228457
Publication date: November 11, 2020
PMID: 33187070

October 2020

Expression Screening of Human Integral Membrane Proteins Using BacMam.
Mahajan P, Ellis K, Mukhopadhyay S, Fernandez-Cid A, Chi G, Man H, Dürr KL, Burgess-Brown NA
Methods Mol Biol 2199:95-115 . doi: 10.1007/978-1-0716-0892-0_6
Publication date: October 31, 2020
PMID: 33125646
Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells.
Mahajan P, Strain-Damerell C, Mukhopadhyay S, Fernandez-Cid A, Gileadi O, Burgess-Brown NA
Methods Mol Biol 2199:67-94 . doi: 10.1007/978-1-0716-0892-0_5
Publication date: October 31, 2020
PMID: 33125645
Screening and Production of Recombinant Human Proteins: Protein Production in E. coli.
Burgess-Brown NA, Mahajan P, Strain-Damerell C, Fernandez-Cid A, Gileadi O, Gräslund S
Methods Mol Biol 2199:45-66 . doi: 10.1007/978-1-0716-0892-0_4
Publication date: October 31, 2020
PMID: 33125644
Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning.
Strain-Damerell C, Mahajan P, Fernandez-Cid A, Gileadi O, Burgess-Brown NA
Methods Mol Biol 2199:23-43 . doi: 10.1007/978-1-0716-0892-0_3
Publication date: October 31, 2020
PMID: 33125643
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.
Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW
Front Mol Neurosci 13:538219 . doi: 10.3389/fnmol.2020.538219
Publication date: October 31, 2020
PMID: 33122997
Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.
Schröder M, Filippakopoulos P, Schwalm MP, Ferrer CA, Drewry DH, Knapp S, Chaikuad A
Int J Mol Sci 21(21): . doi: 10.3390/ijms21217953
Publication date: October 26, 2020
PMID: 33114754
RecQ helicases in DNA repair and cancer targets.
Newman JA, Gileadi O
Essays Biochem 64(5):819-830 . doi: 10.1042/EBC20200012
Publication date: October 26, 2020
PMID: 33095241
Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics.
Meijer I, Willems S, Ni X, Heering J, Chaikuad A, Merk D
Int J Mol Sci 21(21): . doi: 10.3390/ijms21217895
Publication date: October 24, 2020
PMID: 33114319
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB, Kavanagh J, Chau KK, Downs LO, Cox S, Dunn L, Justice A, Wareing S, Dingle K, Rudkin J, Auckland K, Fyfe A, Bolton J, Paton R, Mentzer AJ, Jeffery K, Andersson MI, James T, Peto TEA, Marsden BD, Screaton G, Cornall RJ, Klenerman P, Ebner D, Stuart DI, Crook DW, Stoesser N, Kennedy SH, Thompson C, Gupta S, Matthews PC
Euro Surveill 25(42): . doi: 10.2807/1560-7917.ES.2020.25.41.2001721
Publication date: October 24, 2020
PMID: 33094717
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, Von Delft F, Dowson CG, Spring DR
Chemical Science 11:10792-10801 . doi: 10.1039/d0sc01232g
Publication date: October 20, 2020
PMID:
Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation.
Elie J, Feizbakhsh O, Desban N, Josselin B, Baratte B, Bescond A, Duez J, Fant X, Bach S, Marie D, Place M, Ben Salah S, Chartier A, Berteina-Raboin S, Chaikuad A, Knapp S, Carles F, Bonnet P, Buron F, Routier S, Ruchaud S
J Enzyme Inhib Med Chem 35(1):1840-1853 . doi: 10.1080/14756366.2020.1825408
Publication date: October 13, 2020
PMID: 33040634
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.
Silva SF, Klippel AH, Ramos PZ, Santiago ADS, Valentini SR, Bengtson MH, Massirer KB, Bilsland E, Couñago RM, Zanelli CF
PLoS Negl Trop Dis 14(10):e0008762 . doi: 10.1371/journal.pntd.0008762
Publication date: October 12, 2020
PMID: 33044977
Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.
Álvarez-Coiradas E, Munteanu CR, Díaz-Sáez L, Pazos A, Huber KVM, Loza MI, Domínguez E
Int Immunopharmacol 89(Pt A):107026 . doi: 10.1016/j.intimp.2020.107026
Publication date: October 9, 2020
PMID: 33045560
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models.
Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, Glass M, Greig IR, Ross RA
Neuropsychopharmacology . doi: 10.1038/s41386-020-00876-5
Publication date: October 8, 2020
PMID: 33036015
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandão-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keserü GM, Klein HF, Martin MP, Noble MEM, O'Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA
Nat Commun 11(1):5047 . doi: 10.1038/s41467-020-18709-w
Publication date: October 7, 2020
PMID: 33028810
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Vilema-Enríquez G, Quinlan R, Kilfeather P, Mazzone R, Saqlain S, Del Molino Del Barrio I, Donato A, Corda G, Li F, Vedadi M, Németh AH, Brennan PE, Wade-Martins R
J Biol Chem . doi: 10.1074/jbc.RA120.015533
Publication date: October 7, 2020
PMID: 33028632
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandão-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keserü GM, Klein HF, Martin MP, Noble MEM, O’Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA
Nature Communications 11:5047- . doi: 10.1038/s41467-020-18709-w
Publication date: October 6, 2020
PMID: 33028810
Translational Control during Mammalian Neocortex Development and Postembryonic Neuronal Function.
Oliveira NCM, Lins ÉM, Massirer KB, Bengtson MH
Semin Cell Dev Biol . doi: 10.1016/j.semcdb.2020.09.006
Publication date: October 2, 2020
PMID: 33020045

September 2020

Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway.
Juettner NE, Bogen JP, Bauer TA, Knapp S, Pfeifer F, Huettenhain SH, Meusinger R, Kraemer A, Fuchsbauer HL
J. Nat. Prod. . doi: 10.1021/acs.jnatprod.0c00201
Publication date: September 30, 2020
PMID: 32998509
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020
Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB, Kavanagh J, Chau KK, Downs LO, Cox S, Dunn L, Justice A, Wareing S, Dingle K, Rudkin J, Auckland K, Fyfe A, Bolton J, Paton R, Mentzer AJ, Jeffery K, Andersson MI, James T, Peto TEA, Marsden BD, Screaton G, Cornall RJ, Klenerman P, Ebner D, Stuart DI, Crook DW, Stoesser N, Kennedy SH, Thompson C, Gupta S, Matthews PC
Eurosurveillance 25:- . doi: 10.2807/1560-7917.es.2020.25.41.2001721
Publication date: September 30, 2020
PMID: 33094717
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S, Wolf E
Nat. Chem. Biol. . doi: 10.1038/s41589-020-00652-y
Publication date: September 28, 2020
PMID: 32989298
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor.
Tamir TY, Drewry DH, Wells C, Major MB, Axtman AD
Sci Rep 10(1):15826 . doi: 10.1038/s41598-020-72869-9
Publication date: September 28, 2020
PMID: 32985588
Structural and functional diversity calls for a new classification of ABC transporters.
Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinket HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R
FEBS Lett. . doi: 10.1002/1873-3468.13935
Publication date: September 26, 2020
PMID: 32978974
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
Ainsworth M, Andersson M, Auckland K, Baillie JK, Barnes E, Beer S, Beveridge A, Bibi S, Blackwell L, Borak M, Bown A, Brooks T, Burgess-Brown NA, Camara S, Catton M, Chau KK, Christott T, Clutterbuck E, Coker J, Cornall RJ, Cox S, Crawford-Jones D, Crook DW, D'Arcangelo S, Dejnirattsai W, Dequaire JMM, Dimitriadis S, Dingle KE, Doherty G, Dold C, Dong T, Dunachie SJ, Ebner D, Emmenegger M, Espinosa A, Eyre DW, Fairhead R, Fassih S, Feehily C, Felle S, Fernandez-Cid A, Fernandez Mendoza M, Foord TH, Fordwoh T, Fox McKee D, Frater J, Gallardo Sanchez V, Gent N, Georgiou D, Groves CJ, Hallis B, Hammond PM, Hatch SB, Harvala HJ, Hill J, Hoosdally SJ, Horsington B, Howarth A, James T, Jeffery K, Jones E, Justice A, Karpe F, Kavanagh J, Kim DS, Kirton R, Klenerman P, Knight JC, Koukouflis L, Kwok A, Leuschner U, Levin R, Linder A, Lockett T, Lumley SF, Marinou S, Marsden BD, Martinez J, Martins Ferreira L, Mason L, Matthews PC, Mentzer AJ, Mobbs A, Mongkolsapaya J, Morrow J, Mukhopadhyay SMM, Neville MJ, Oakley S, Oliveira M, Otter A, Paddon K, Pascoe J, Peng Y, Perez E, Perumal PK, Peto TEA, Pickford H, Ploeg RJ, Pollard AJ, Richardson A, Ritter TG, Roberts DJ, Rodger G, Rollier CS, Rowe C, Rudkin JK, Screaton G, Semple MG, Sienkiewicz A, Silva-Reyes L, Skelly DT, Sobrino Diaz A, Stafford L, Stockdale L, Stoesser N, Street T, Stuart DI, Sweed A, Taylor A, Thraves H, Tsang HP, Verheul MK, Vipond R, Walker TM, Wareing S, Warren Y, Wells C, Wilson C, Withycombe K, Young RK
The Lancet Infectious Diseases . doi: 10.1016/s1473-3099(20)30634-4
Publication date: September 22, 2020
PMID: 32979318
Concise, gram-scale synthesis of furo[2,3-b]pyridines with functional handles for chemoselective cross-coupling.
O'Byrne SN, Eduful BJ, Willson TM, Drewry DH
Tetrahedron Lett 61(38): . doi: 10.1016/j.tetlet.2020.152353
Publication date: September 17, 2020
PMID: 33012852
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.
Schuhmacher MK, Beldar S, Khella MS, Bröhm A, Ludwig J, Tempel W, Weirich S, Min J, Jeltsch A
Commun Biol 3(1):511 . doi: 10.1038/s42003-020-01223-6
Publication date: September 16, 2020
PMID: 32939018
NeuroChat with Research Assistant Professor Alison Axtman.
Lindsley CW, Axtman AD
ACS Chem Neurosci 11(18):2783-2785 . doi: 10.1021/acschemneuro.0c00548
Publication date: September 16, 2020
PMID: 32933260
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ
Sci Adv 6(37): . doi: 10.1126/sciadv.abc0367
Publication date: September 13, 2020
PMID: 32917713
Nanopore Enzymology to Study Protein Kinases and Their Inhibition by Small Molecules.
Harrington L, Alexander LT, Knapp S, Bayley H
Methods Mol. Biol. 2186:95-114 . doi: 10.1007/978-1-0716-0806-7_8
Publication date: September 13, 2020
PMID: 32918732
What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?
Edwards A
J Chem Inf Model . doi: 10.1021/acs.jcim.0c00861
Publication date: September 11, 2020
PMID: 32914973
Ten simple rules for open human health research.
Bafeta A, Bobe J, Clucas J, Gonsalves PP, Gruson-Daniel C, Hudson KL, Klein A, Krishnakumar A, McCollister-Slipp A, Lindner AB, Misevic D, Naslund JA, Nebeker C, Nikolaidis A, Pasquetto I, Sanchez G, Schapira M, Scheininger T, Schoeller F, Sólon Heinsfeld A, Taddei F
PLoS Comput. Biol. 16(9):e1007846 . doi: 10.1371/journal.pcbi.1007846
Publication date: September 4, 2020
PMID: 32881878

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