Publications

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Displaying 101 - 150 of 1775

2019

September 2019

Fostering open collaboration in drug development for paediatric brain tumours
BULLOCK A, WILLIAMS E, WONG JF, Brown EJ
Biochemical Society Transactions 47:1471-1479 . doi: 10.1042/bst20190315
Publication date: September 23, 2019
PMID: 31551357
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function
Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford JE, Nibhani R, Philpott M, Malzahn J, Wells G, Farham R, Cribbs A, Halidi N, Li F, Chau I, Greschik H, Velupillai S, Allali-Hassani A, Bennett JM, Christott T, Giroud C, Lewis AM, Huber KVM, Athanasou N, Bountra C, Jung M, Schüle R, Vedadi M, Arrowsmith CH, Xiong Y, Jin J, Fedorov O, Farnie G, Brennan PE, Oppermann UCT
Journal of Medicinal Chemistry 62:9008-9025 . doi: 10.1021/acs.jmedchem.9b00562
Publication date: September 23, 2019
PMID: 31550156
Regulation of DGKε Activity and Substrate Acyl Chain Specificity by Negatively Charged Phospholipids.
Bozelli JC, Yune J, Hou YH, Chatha P, Fernandes A, Cao Z, Tong Y, Epand RM
Biophys. J. . doi: 10.1016/j.bpj.2019.09.008
Publication date: September 16, 2019
PMID: 31587830
The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity
Righetto GL, Sriranganadane D, Halabelian L, Chiodi CG, Elkins JM, Massirer KB, Gileadi O, Menossi M, Couñago RM
Frontiers in Plant Science 10:1105- . doi: 10.3389/fpls.2019.01105
Publication date: September 16, 2019
PMID: 31620147
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2
Serafim RAM, De Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, Da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM
ACS Medicinal Chemistry Letters 10:1266-1271 . doi: 10.1021/acsmedchemlett.9b00082
Publication date: September 12, 2019
PMID: 31531195
Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140
Fairhead M, Preger C, Wigren E, Strain-Damerell C, Ossipova E, Ye M, Makola M, Burgess-Brown NA, Persson H, von Delft F, Gräslund S
. doi: 10.1101/767376
Publication date: September 12, 2019
PMID:
A Chemical Probe Targeting AAK1 and BMP2K
Wells C, Counago R, Limas J, Almeida T, Cook J, Drewry D, Elkins J, Gileadi O, Kapadia N, Lorente-Macías Á, Pickett J, Riemen A, R. Ruela-de-Sousa R, Willson T, Zhang C, Zuercher W, Zutshi R, Axtman A
. doi: 10.26434/chemrxiv.9756785.v1
Publication date: September 3, 2019
PMID:
Structural basis for recruitment of DAPK1 to the KLHL20 E3 ligase
BULLOCK A, CHEN Z, PICAUD S, FILIPPAKOPOULOS P, D'ANGIOLELLA V
Structure 27:1395-1404.e4 . doi: 10.1016/j.str.2019.06.005
Publication date: September 3, 2019
PMID: 31279627
LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.
Izumikawa K, Ishikawa H, Yoshikawa H, Fujiyama S, Watanabe A, Aburatani H, Tachikawa H, Hayano T, Miura Y, Isobe T, Simpson RJ, Li L, Min J, Takahashi N
Nucleic Acids Res. . doi: 10.1093/nar/gkz747
Publication date: September 2, 2019
PMID: 31504794
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nature Communications 10:3956- . doi: 10.1038/s41467-019-11753-1
Publication date: September 1, 2019
PMID: 31477691
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4)inhibitors, compound profiling in cell-based target engagement assays
Le Bihan YV, Lanigan RM, Atrash B, McLaughlin MG, Velupillai S, Malcolm AG, England KS, Ruda GF, Mok NY, Tumber A, Tomlin K, Saville H, Shehu E, McAndrew C, Carmichael LA, Bennett JM, Jeganathan F, Eve P, Donovan A, Hayes A, Wood F, Raynaud FI, Fedorov O, Brennan PE, Burke R, van Montfort RLM, Rossanese OW, Blagg J, Bavetsias V
European Journal of Medicinal Chemistry 177:316-337 . doi: 10.1016/j.ejmech.2019.05.041
Publication date: September 1, 2019
PMID: 31158747

August 2019

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma DC, Vázquez MJ, Colmenarejo G, Lafuente-Monasterio MJ, Leon ML, Godoi PHC, Elkins JM, Waters AP, Jamieson AG, Álvaro EF, Ranford-Cartwright LC, Marti M, Winzeler EA, Gamo FJ, Tobin AB
Science 365:884-+ . doi: 10.1126/science.aau1682
Publication date: August 30, 2019
PMID: 31467193
The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency
Keshavan N, Abdenur J, Anderson G, Assouline Z, Barcia G, Bouhikbar L, Chakrapani A, Cleary M, Cohen MC, Feillet F, Fratter C, Hauser N, Jacques T, Lam A, McCullagh H, Phadke R, Rötig A, Sharrard M, Simon M, Smith C, Sommerville EW, Taylor RW, Yue WW, Rahman S
Genetics in Medicine . doi: 10.1038/s41436-019-0613-z
Publication date: August 29, 2019
PMID: 31462754
Open laboratory notebooks: good for science, good for society, good for scientists.
Schapira M, Harding RJ
F1000Res 8:87 . doi: 10.12688/f1000research.17710.1
Publication date: August 27, 2019
PMID: 31448096
Target highlights in CASP13: experimental target structures through the eyes of their authors.
Lepore R, Kryshtafovych A, Alahuhta M, Arora Veraszto H, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra A, Moult J, Phillips GN, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T
Proteins . doi: 10.1002/prot.25805
Publication date: August 23, 2019
PMID: 31442339
Evaluation of linker length effects on a BET bromodomain probe
Traquete R, Henderson E, Picaud S, Cal PMSD, Sieglitz F, Rodrigues T, Oliveira R, Filippakopoulos P, Bernardes GJL
Chemical Communications 55:10128-10131 . doi: 10.1039/c9cc05054j
Publication date: August 20, 2019
PMID: 31386708
Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.
Taylor AP, Szewczyk MM, Kennedy S, Trush VV, Wu H, Zeng H, Dong A, de Freitas RF, Tatlock JH, Kumpf RA, Wythes M, Casimiro-Garcia A, Denny RA, Parikh MD, Li F, Barsyte-Lovejoy D, Schapira M, Vedadi M, Brown P, Arrowsmith CH, Owen DR
J. Med. Chem. . doi: 10.1021/acs.jmedchem.9b00112
Publication date: August 15, 2019
PMID: 31415173
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.
Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O, Guccione E
Cancer Cell 36(2):194-209.e9 . doi: 10.1016/j.ccell.2019.07.003
Publication date: August 12, 2019
PMID: 31408619
The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
Kaustov L, Lemak A, Wu H, Faini M, Fan L, Fang X, Zeng H, Duan S, Allali-Hassani A, Li F, Wei Y, Vedadi M, Aebersold R, Wang Y, Houliston S, Arrowsmith CH
Nucleic Acids Res. . doi: 10.1093/nar/gkz697
Publication date: August 10, 2019
PMID: 31400120
A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin
Lim M, Newman JA, Williams HL, Masino L, Aitkenhead H, Gravard AE, Gileadi O, Svejstrup JQ
Structure 27:1316-1325.e6 . doi: 10.1016/j.str.2019.05.003
Publication date: August 6, 2019
PMID: 31204252
2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
Zhu D, Huang H, Pinkas DM, Luo J, Ganguly D, Fox AE, Arner E, Xiang Q, Tu Z-C, Bullock AN, Brekken RA, Ding K, Lu X
Journal of Medicinal Chemistry 62:7431-7444 . doi: 10.1021/acs.jmedchem.9b00365
Publication date: August 2, 2019
PMID: 31310125
Regulation of influenza A virus mRNA splicing by CLK1
Artarini A, Meyer M, Shin YJ, Huber K, Hilz N, Bracher F, Eros D, Orfi L, Keri G, Goedert S, Neuenschwander M, von Kries J, Domovich-Eisenberg Y, Dekel N, Szabadkai I, Lebendiker M, Horváth Z, Danieli T, Livnah O, Moncorgé O, Frise R, Barclay W, Meyer TF, Karlas A
Antiviral Research 168:187-196 . doi: 10.1016/j.antiviral.2019.06.003
Publication date: August 1, 2019
PMID: 31176694

July 2019

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Lei M, Tempel W, Chen S, Liu K, Min J
Biochim Biophys Acta Gene Regul Mech 194409 . doi: 10.1016/j.bbagrm.2019.194409
Publication date: July 26, 2019
PMID: 31356990
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
Abdul Azeez KR, Chatterjee S, Yu C, Golub TR, Sobott F, Elkins JM
Nature Communications 10:3166- . doi: 10.1038/s41467-019-11085-0
Publication date: July 18, 2019
PMID: 31320618
Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless VB, Liew SK, Houliston SR, De Freitas RF, Smil D, Sena CCD, Kennedy S, Diaz DB, Wu H, Dombrovski L, Allali-Hassani A, Min J, Schapira M, Vedadi M, Brown PJ, Santhakumar V, Yudin AK, Arrowsmith CH
Bioorg. Med. Chem. . doi: 10.1016/j.bmc.2019.07.020
Publication date: July 12, 2019
PMID: 31327677
A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.
Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A
Cancer Cell 36(1):51-67.e7 . doi: 10.1016/j.ccell.2019.06.002
Publication date: July 8, 2019
PMID: 31287992
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, Huber KVM, Rogers CM, Wells CI, Fedorov O, Rumpel K, Zoephel A, Mayer M, Wunberg T, Böse D, Zahn S, Arnhof H, Berger H, Reiser C, Hörmann A, Krammer T, Corcokovic M, Sharps B, Winkler S, Häring D, Cockcroft XL, Fuchs JE, Müllauer B, Weiss-Puxbaum A, Gerstberger T, Boehmelt G, Vakoc CR, Arrowsmith CH, Pearson M, McConnell DB
Nat. Chem. Biol. . doi: 10.1038/s41589-019-0310-x
Publication date: July 8, 2019
PMID: 31285596
Peptide Hydrogels of Fully-Defined Composition & Mechanics for Probing Cell-Cell & Cell-Matrix Interactions In Vitro
Ashworth J, Thompsona J, Jamesa J, Slatera C, Pijuan-Galitoa S, Lis-Slimaka K, Holleyc R, Mead K, Thompsone A, Arkille K, Tassierif M, Wrightg A, FARNIE G, merry C
Matrix Biology . doi: 10.1016/j.matbio.2019.06.009
Publication date: July 8, 2019
PMID: 31295578
Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1.
Chen S, Zhang W, Min J, Liu K
Methods . doi: 10.1016/j.ymeth.2019.07.002
Publication date: July 6, 2019
PMID: 31288074
High-throughput site-directed mutagenesis
Strain-Damerell C, Burgess-Brown NA
Methods Mol Biol 2025:281-296 . doi: 10.1007/978-1-4939-9624-7_13
Publication date: July 3, 2019
PMID: 31267458
Target 2035: probing the human proteome.
Carter AJ, Kraemer O, Zwick M, Mueller-Fahrnow A, Arrowsmith CH, Edwards AM
Drug Discov. Today . doi: 10.1016/j.drudis.2019.06.020
Publication date: July 3, 2019
PMID: 31278990
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
Xiong Y, Greschik H, Johansson C, Seifert L, Bacher J, Park KS, Babault N, Martini ML, Fagan V, Li F, Chau I, Christott T, Dilworth D, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Brennan PE, Fedorov O, Jung M, Farnie G, Liu J, Oppermann UCT, Schüle R, Jin J
J. Med. Chem. . doi: 10.1021/acs.jmedchem.9b00522
Publication date: July 1, 2019
PMID: 31260300
Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy
Wu X, Scott H, Carlsson SV, Sjoberg DD, Cerundolo L, Lilja H, Prevo R, Rieunier G, Macaulay V, Higgins GS, Verrill CL, Lamb AD, Cunliffe VT, Bountra C, Hamdy FC, Bryant RJ
The Prostate 79:1079-1089 . doi: 10.1002/pros.23817
Publication date: July 1, 2019
PMID: 31104332

June 2019

Streamlining the production of proteins for structural biology
Owens RJ, Gileadi O
Biophysical Reviews 11:533-534 . doi: 10.1007/s12551-019-00565-8
Publication date: June 27, 2019
PMID: 31250316
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui R
Proc. Natl. Acad. Sci. U.S.A. . doi: 10.1073/pnas.1905558116
Publication date: June 25, 2019
PMID: 31239348
Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Halabelian L, Ravichandran M, Li Y, Zeng H, Rao A, Aravind L, Arrowsmith CH
Nat. Struct. Mol. Biol. . doi: 10.1038/s41594-019-0246-6
Publication date: June 24, 2019
PMID: 31235913
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S
Journal of Medicinal Chemistry 62:5810-5831 . doi: 10.1021/acs.jmedchem.9b00136
Publication date: June 12, 2019
PMID: 31136173
Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency
Knerr I, Colombo R, Urquhart J, Morais A, Merinero B, Oyarzabal A, Pérez B, Jones SA, Perveen R, Preece MA, Rogers Y, Treacy EP, Mayne P, Zampino G, MacKinnon S, Wassmer E, Yue WW, Robinson I, Rodríguez-Pombo P, Olpin SE, Banka S
Journal of Inherited Metabolic Disease 42:809-817 . doi: 10.1002/jimd.12135
Publication date: June 8, 2019
PMID: 31177572
Structural and functional consequences of the STAT5BN642H driver mutation.
de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT
Nat Commun 10(1):2517 . doi: 10.1038/s41467-019-10422-7
Publication date: June 7, 2019
PMID: 31175292
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N
Journal of the American Chemical Society 141:8951-8968 . doi: 10.1021/jacs.9b02822
Publication date: June 5, 2019
PMID: 31060360
Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency
Heuberger K, Bailey HJ, Burda P, Chaikuad A, Krysztofinska E, Suormala T, Bürer C, Lutz S, Fowler B, Froese DS, Yue WW, Baumgartner MR
Biochimica et Biophysica Acta - Molecular Basis of Disease 1865:1265-1272 . doi: 10.1016/j.bbadis.2019.01.021
Publication date: June 1, 2019
PMID: 30682498

May 2019

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S, Sun Y-B, Fraternali F, Eaton P, Conte MR
Communications biology 2:188-188 . doi: 10.1038/s42003-019-0426-2
Publication date: May 17, 2019
PMID: 31123712
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S
Nature Communications 10:2210- . doi: 10.1038/s41467-019-09989-y
Publication date: May 17, 2019
PMID: 31101807
The dynamic conformational landscape of the protein methyltransferase SETD8.
Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H, Zou H, Wang J, Fan S, Blum G, Pittella-Silva F, Beauchamp KA, Tempel W, Jiang H, Chen K, Skene RJ, Zheng YG, Brown PJ, Jin J, Luo C, Chodera JD, Luo M
Elife 8: . doi: 10.7554/eLife.45403
Publication date: May 13, 2019
PMID: 31081496
Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase
Zhang R, McIntyre PJ, Collins PM, Foley DJ, Arter C, von Delft F, Bayliss R, Warriner S, Nelson A
Chemistry – A European Journal 25:6831-6839 . doi: 10.1002/chem.201900815
Publication date: May 10, 2019
PMID: 31026091
Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
Huang L, Li H, Li L, Niu L, Seupel R, Wu C, Cheng W, Chen C, Ding B, Brennan PE, Yang S
Journal of medicinal chemistry 62:4526-4542 . doi: 10.1021/acs.jmedchem.9b00096
Publication date: May 9, 2019
PMID: 30998845
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
Carvalho D, Taylor KR, Olaciregui NG, Molinari V, Clarke M, Mackay A, Ruddle R, Henley A, Valenti M, Hayes A, Brandon ADH, Eccles SA, Raynaud F, Boudhar A, Monje M, Popov S, Moore AS, Mora J, Cruz O, Vinci M, Brennan PE, Bullock AN, Carcaboso AM, Jones C
Communications Biology 2:156- . doi: 10.1038/s42003-019-0420-8
Publication date: May 9, 2019
PMID: 31098401
Structure and function of eTudor domain containing TDRD proteins.
Gan B, Chen S, Liu H, Min J, Liu K
Crit. Rev. Biochem. Mol. Biol. 1-14 . doi: 10.1080/10409238.2019.1603199
Publication date: May 3, 2019
PMID: 31046474
Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening
Wempe MF, Kumar A, Kumar V, Choi YJ, Swanson MA, Friederich MW, Hyland K, Yue WW, Van Hove JLK, Coughlin CR
Journal of Inherited Metabolic Disease 42:565-574 . doi: 10.1002/jimd.12059
Publication date: May 1, 2019
PMID: 30663059

April 2019

Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 377:20180422-20180422 . doi: 10.1098/rsta.2018.0422
Publication date: April 29, 2019
PMID: 31030650

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