Publications

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Displaying 151 - 200 of 2122

2020

June 2020

Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
Zhang X, Zegar T, Weiser T, Hamdan FH, Berger BT, Lucas R, Balourdas DI, Ladigan S, Cheung PF, Liffers ST, Trajkovic-Arsic M, Scheffler B, Joerger AC, Hahn SA, Johnsen SA, Knapp S, Siveke JT
Int. J. Cancer . doi: 10.1002/ijc.33137
Publication date: June 29, 2020
PMID: 32599645
Identifying the target of an antiparasitic compound in Toxoplasma using thermal proteome profiling.
Herneisen AL, Sidik SM, Markus BM, Drewry DH, Zuercher WJ, Lourido S
ACS Chem. Biol. . doi: 10.1021/acschembio.0c00369
Publication date: June 29, 2020
PMID: 32597628
Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanisms
Mokaya J, McNaughton AL, Bester PA, Goedhals D, Barnes E, Marsden BD, Matthews PC
Wellcome Open Research 5:151-151 . doi: 10.12688/wellcomeopenres.15992.1
Publication date: June 28, 2020
PMID:
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.
Gütschow M, Eynde JJV, Jampilek J, Kang C, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D
Molecules 25(13): . doi: 10.3390/molecules25132968
Publication date: June 28, 2020
PMID: 32605268
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA
Mol. Cell . doi: 10.1016/j.molcel.2020.06.018
Publication date: June 24, 2020
PMID: 32619402
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
Chen Z, Wasney GA, Picaud S, Filippakopoulos P, Vedadi M, D'Angiolella V, Bullock AN
Open Biol 10(6):200041 . doi: 10.1098/rsob.200041
Publication date: June 24, 2020
PMID: 32574548
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.
Chen Z, Wasney GA, Picaud S, Filippakopoulos P, Vedadi M, D'Angiolella V, Bullock AN
Open Biol 10(6):200041 . doi: 10.1098/rsob.200041
Publication date: June 24, 2020
PMID: 32574548
Crowdsourcing drug discovery for pandemics.
Chodera J, Lee AA, London N, von Delft F
Nat Chem . doi: 10.1038/s41557-020-0496-2
Publication date: June 18, 2020
PMID: 32555379
Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer.
Deblois G, Madani Tonekaboni SA, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, Ba-Alawi W, Cescon DW, Arrowsmith CH, De Carvalho DD, Haibe-Kains B, Locasale JW, Park M, Lupien M
Cancer Discov . doi: 10.1158/2159-8290.CD-19-1493
Publication date: June 16, 2020
PMID: 32546577
Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D.
Tong MHG, Jeeves M, Rajesh S, Ludwig C, Lenoir M, Kumar J, McClelland DM, Berditchevski F, Hubbard JA, Kenyon C, Butterworth S, Knapp S, Overduin M
Biomol NMR Assign . doi: 10.1007/s12104-020-09950-x
Publication date: June 13, 2020
PMID: 32535836
Tuning transcription factor availability through acetylation-mediated genomic redistribution
GODING C
Molecular Cell 79:472-487.e10 . doi: 10.1016/j.molcel.2020.05.025
Publication date: June 10, 2020
PMID: 32531202
Recognition of nonproline N-terminal residues by the Pro/N-degron pathway.
Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A, Min J
Proc. Natl. Acad. Sci. U.S.A. . doi: 10.1073/pnas.2007085117
Publication date: June 8, 2020
PMID: 32513738
Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.
Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR
Mol. Cell . doi: 10.1016/j.molcel.2020.05.025
Publication date: June 4, 2020
PMID: 32531202
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.
Bailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA, Yue WW
Nat Commun 11(1):2813 . doi: 10.1038/s41467-020-16586-x
Publication date: June 4, 2020
PMID: 32499479
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release
Bailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA, Yue WW
Nature Communications 11:2813- . doi: 10.1038/s41467-020-16586-x
Publication date: June 3, 2020
PMID: 32499479
Quantifying CDK inhibitor selectivity in live cells.
Wells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang BB, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB
Nat Commun 11(1):2743 . doi: 10.1038/s41467-020-16559-0
Publication date: June 2, 2020
PMID: 32488087
Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs).
Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV
Endocr. Relat. Cancer . doi: 10.1530/ERC-20-0127
Publication date: June 1, 2020
PMID: 32590358
Quantifying CDK inhibitor selectivity in live cells
Wells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang B, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB
Nature Communications 11:2743- . doi: 10.1038/s41467-020-16559-0
Publication date: June 1, 2020
PMID: 32488087

May 2020

Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs)
Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV
Endocrine-related cancer 27:R345-R355 . doi: 10.1530/ERC-20-0127
Publication date: May 31, 2020
PMID: 32590358
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M
Life Sci Alliance 3(7): . doi: 10.26508/lsa.202000725
Publication date: May 30, 2020
PMID: 32467316
Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases.
Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD
ACS Chem Neurosci . doi: 10.1021/acschemneuro.0c00176
Publication date: May 28, 2020
PMID: 32464049
Bioisosteric Replacement of Arylamide-linked Spine Residues by N-Acylhydrazones and Selenophenes as Design Strategy to Novel Dibenzosuberone Derivatives as Type I½ p38 MAP Kinase Inhibitors.
Galvez Bulh Otilde Es Pedreira JUL, Nahidino P, Kudolo M, Pantsar T, Berger BT, Forster M, Knapp S, Laufer SA, Barreiro EJ
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00508
Publication date: May 28, 2020
PMID: 32462866
HighVia-A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity.
Howarth A, Schröder M, Montenegro RC, Drewry DH, Heba S, Millar V, Müller S, Ebner DV
SLAS Discov 2472555220923979 . doi: 10.1177/2472555220923979
Publication date: May 27, 2020
PMID: 32458721
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J
Cell Chem Biol . doi: 10.1016/j.chembiol.2020.05.007
Publication date: May 26, 2020
PMID: 32470319
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
KROJER T, Douangamath A, Fearon D, Gehrtz P, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandaõ-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, FAIRHEAD M, Firth JD, Jones P, Keely A, Keserü GM, Klein HF, Martin MP, Noble MEM, O’Brien P, Powell A, Reddi R, Skyner R, Snee M, Waring MJ, Wild C, London N, VON DELFT F, Walsh ME
biorxiv . doi: 10.1101/2020.05.27.118117
Publication date: May 26, 2020
PMID:
Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini G, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaia V, Morgan J, Sorrell F, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers S, Cheetham S, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S
J. Med. Chem. . doi: 10.1021/acs.jmedchem.9b01803
Publication date: May 20, 2020
PMID: 32433887
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD
Cell . doi: 10.1016/j.cell.2020.04.047
Publication date: May 20, 2020
PMID: 32445698
Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response.
Barreto P, Miguez Couñago R, Arruda P
Mitochondrion . doi: 10.1016/j.mito.2020.05.001
Publication date: May 18, 2020
PMID: 32439620
Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer.
Baguña Torres J, Mosley M, Koustoulidou S, Hopkins S, Knapp S, Chaikuad A, Kondoh M, Tachibana K, Kersemans V, Cornelissen B
J. Nucl. Med. . doi: 10.2967/jnumed.120.243113
Publication date: May 15, 2020
PMID: 32414951
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD
Eur J Med Chem 200:112417 . doi: 10.1016/j.ejmech.2020.112417
Publication date: May 15, 2020
PMID: 32505849
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, von Delft F, Dowson CG, Spring DR
Chem Sci 11(39):10792-10801 . doi: 10.1039/d0sc01232g
Publication date: May 14, 2020
PMID: 34094333
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD
European Journal of Medicinal Chemistry 200:112417- . doi: 10.1016/j.ejmech.2020.112417
Publication date: May 14, 2020
PMID: 32505849
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy D
Nat Commun 11(1):2396 . doi: 10.1038/s41467-020-16271-z
Publication date: May 14, 2020
PMID: 32409666
GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.
Foley AR, Zou Y, Dunford JE, Rooney J, Chandra G, Xiong H, Straub V, Voit T, Romero N, Donkervoort S, Hu Y, Markello T, Horn A, Qebibo L, Dastgir J, Meilleur K, Finkel RS, Fan Y, Mamchaoui K, Duguez S, Nelson I, Laporte J, Santi M, Malfatti E, Maisonobe T, Touraine P, Hirano M, Hughes I, Bushby K, Oppermann U, Böhm J, Jaiswal JK, Stojkovic T, Bönnemann CG
Ann. Neurol. . doi: 10.1002/ana.25772
Publication date: May 13, 2020
PMID: 32403198
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00395
Publication date: May 5, 2020
PMID: 32369358
Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.
Shen Y, Li F, Szewczyk MM, Halabelian L, Park KS, Chau I, Dong A, Zeng H, Chen H, Meng F, Barsyte-Lovejoy D, Arrowsmith CH, Brown P, Liu J, Vedadi M, Jin J
J. Med. Chem. . doi: 10.1021/acs.jmedchem.0c00406
Publication date: May 5, 2020
PMID: 32367723
Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.
Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Müller S, Siveke JT
Oncogene . doi: 10.1038/s41388-020-1301-9
Publication date: May 4, 2020
PMID: 32366905
L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ.
Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D
J. Med. Chem. . doi: 10.1021/acs.jmedchem.9b02150
Publication date: May 1, 2020
PMID: 32356658

April 2020

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.
Ketley A, Wojciechowska M, Ghidelli-Disse S, Bamborough P, Ghosh TK, Morato ML, Sedehizadeh S, Malik NA, Tang Z, Powalowska P, Tanner M, Billeter-Clark R, Trueman RC, Geiszler PC, Agostini A, Othman O, Bösche M, Bantscheff M, Rüdiger M, Mossakowska DE, Drewry DH, Zuercher WJ, Thornton CA, Drewes G, Uings I, Hayes CJ, Brook JD
Sci Transl Med 12(541): . doi: 10.1126/scitranslmed.aaz2415
Publication date: April 29, 2020
PMID: 32350131
A lower X-gate in TASK channels traps inhibitors within the vestibule.
Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N, Carpenter EP
Nature . doi: 10.1038/s41586-020-2250-8
Publication date: April 29, 2020
PMID: 32499642
A lower X-gate in TASK channels traps inhibitors within the vestibule
RODSTROM K, Kiper A, Zhang W, Rinne S, PIKE A, Goldstein M, Conrad L, Delbeck M, Hahn M, Meier H, Platzk M, Quigley A, Speedman D, SHRESTHA L, Mukhopadhyay S, BURGESS-BROWN N, TUCKER S, Mueller T, Decher N, CARPENTER E
Nature 582:443-447 . doi: 10.1038/s41586-020-2250-8
Publication date: April 28, 2020
PMID: 32499642
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.
Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L
Elife 9: . doi: 10.7554/eLife.47333
Publication date: April 16, 2020
PMID: 32297856
Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding.
Aquino B, da Silva VCH, Massirer KB, Arruda P
BMC Plant Biol. 20(1):158 . doi: 10.1186/s12870-020-2328-3
Publication date: April 15, 2020
PMID: 32293271
Targeting der kleinen GTPasen über ihre regulatorischen Proteine
Gray JL, Delft F, Brennan PE
Angewandte Chemie 132:6402-6428 . doi: 10.1002/ange.201900585
Publication date: April 15, 2020
PMID:
Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer
Scott F, Fala AM, Pennicott LE, Reuillon TD, Massirer KB, Elkins JM, Ward SE
Bioorganic and Medicinal Chemistry Letters 30:127040- . doi: 10.1016/j.bmcl.2020.127040
Publication date: April 14, 2020
PMID: 32085971
Importance of Quantifying Drug-Target Engagement in Cells.
Stefaniak J, Huber KVM
ACS Med Chem Lett 11(4):403-406 . doi: 10.1021/acsmedchemlett.9b00570
Publication date: April 9, 2020
PMID: 32292539
The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, Goldmann U, Gürtl B, Klavins K, Klimek C, Lindinger S, Liñeiro-Retes E, Müller AC, Onstein S, Redinger G, Reil D, Sedlyarov V, Wolf G, Crawford M, Everley R, Hepworth D, Liu S, Noell S, Piotrowski M, Stanton R, Zhang H, Corallino S, Faedo A, Insidioso M, Maresca G, Redaelli L, Sassone F, Scarabottolo L, Stucchi M, Tarroni P, Tremolada S, Batoulis H, Becker A, Bender E, Chang YN, Ehrmann A, Müller-Fahrnow A, Pütter V, Zindel D, Hamilton B, Lenter M, Santacruz D, Viollet C, Whitehurst C, Johnsson K, Leippe P, Baumgarten B, Chang L, Ibig Y, Pfeifer M, Reinhardt J, Schönbett J, Selzer P, Seuwen K, Bettembourg C, Biton B, Czech J, de Foucauld H, Didier M, Licher T, Mikol V, Pommereau A, Puech F, Yaligara V, Edwards A, Bongers BJ, Heitman LH, IJzerman AP, Sijben HJ, van Westen GJP, Grixti J, Kell DB, Mughal F, Swainston N, Wright-Muelas M, Bohstedt T, Burgess-Brown N, Carpenter L, Dürr K, Hansen J, Scacioc A, Banci G, Colas C, Digles D, Ecker G, Füzi B, Gamsjäger V, Grandits M, Martini R, Troger F, Altermatt P, Doucerain C, Dürrenberger F, Manolova V, Steck AL, Sundström H, Wilhelm M, Steppan CM
Nat Rev Drug Discov . doi: 10.1038/d41573-020-00056-6
Publication date: April 7, 2020
PMID: 32265506
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).
Asquith CRM, Laitinen T, Wells CI, Tizzard GJ, Zuercher WJ
Molecules 25(7): . doi: 10.3390/molecules25071697
Publication date: April 7, 2020
PMID: 32272798
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
Curran PR, Radoux CJ, Smilova MD, Sykes RA, Higueruelo AP, Bradley AR, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC
Journal of chemical information and modeling 60:1911-1916 . doi: 10.1021/acs.jcim.9b00996
Publication date: April 1, 2020
PMID: 32207937

March 2020

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.
Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J, Min J
Cell Rep 30(12):3996-4002.e4 . doi: 10.1016/j.celrep.2020.03.003
Publication date: March 24, 2020
PMID: 32209463

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