Publications

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Displaying 151 - 200 of 1788

2019

June 2019

Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency
Knerr I, Colombo R, Urquhart J, Morais A, Merinero B, Oyarzabal A, Pérez B, Jones SA, Perveen R, Preece MA, Rogers Y, Treacy EP, Mayne P, Zampino G, MacKinnon S, Wassmer E, Yue WW, Robinson I, Rodríguez-Pombo P, Olpin SE, Banka S
Journal of Inherited Metabolic Disease 42:809-817 . doi: 10.1002/jimd.12135
Publication date: June 8, 2019
PMID: 31177572
Structural and functional consequences of the STAT5BN642H driver mutation.
de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT
Nat Commun 10(1):2517 . doi: 10.1038/s41467-019-10422-7
Publication date: June 7, 2019
PMID: 31175292
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N
Journal of the American Chemical Society 141:8951-8968 . doi: 10.1021/jacs.9b02822
Publication date: June 5, 2019
PMID: 31060360
Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency
Heuberger K, Bailey HJ, Burda P, Chaikuad A, Krysztofinska E, Suormala T, Bürer C, Lutz S, Fowler B, Froese DS, Yue WW, Baumgartner MR
Biochimica et Biophysica Acta - Molecular Basis of Disease 1865:1265-1272 . doi: 10.1016/j.bbadis.2019.01.021
Publication date: June 1, 2019
PMID: 30682498

May 2019

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S, Sun Y-B, Fraternali F, Eaton P, Conte MR
Communications biology 2:188-188 . doi: 10.1038/s42003-019-0426-2
Publication date: May 17, 2019
PMID: 31123712
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S
Nature Communications 10:2210- . doi: 10.1038/s41467-019-09989-y
Publication date: May 17, 2019
PMID: 31101807
The dynamic conformational landscape of the protein methyltransferase SETD8.
Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H, Zou H, Wang J, Fan S, Blum G, Pittella-Silva F, Beauchamp KA, Tempel W, Jiang H, Chen K, Skene RJ, Zheng YG, Brown PJ, Jin J, Luo C, Chodera JD, Luo M
Elife 8: . doi: 10.7554/eLife.45403
Publication date: May 13, 2019
PMID: 31081496
Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase
Zhang R, McIntyre PJ, Collins PM, Foley DJ, Arter C, von Delft F, Bayliss R, Warriner S, Nelson A
Chemistry – A European Journal 25:6831-6839 . doi: 10.1002/chem.201900815
Publication date: May 10, 2019
PMID: 31026091
Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
Huang L, Li H, Li L, Niu L, Seupel R, Wu C, Cheng W, Chen C, Ding B, Brennan PE, Yang S
Journal of medicinal chemistry 62:4526-4542 . doi: 10.1021/acs.jmedchem.9b00096
Publication date: May 9, 2019
PMID: 30998845
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
Carvalho D, Taylor KR, Olaciregui NG, Molinari V, Clarke M, Mackay A, Ruddle R, Henley A, Valenti M, Hayes A, Brandon ADH, Eccles SA, Raynaud F, Boudhar A, Monje M, Popov S, Moore AS, Mora J, Cruz O, Vinci M, Brennan PE, Bullock AN, Carcaboso AM, Jones C
Communications Biology 2:156- . doi: 10.1038/s42003-019-0420-8
Publication date: May 9, 2019
PMID: 31098401
Structure and function of eTudor domain containing TDRD proteins.
Gan B, Chen S, Liu H, Min J, Liu K
Crit. Rev. Biochem. Mol. Biol. 1-14 . doi: 10.1080/10409238.2019.1603199
Publication date: May 3, 2019
PMID: 31046474
Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening
Wempe MF, Kumar A, Kumar V, Choi YJ, Swanson MA, Friederich MW, Hyland K, Yue WW, Van Hove JLK, Coughlin CR
Journal of Inherited Metabolic Disease 42:565-574 . doi: 10.1002/jimd.12059
Publication date: May 1, 2019
PMID: 30663059

April 2019

Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 377:20180422-20180422 . doi: 10.1098/rsta.2018.0422
Publication date: April 29, 2019
PMID: 31030650
Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M
Mol. Cell . doi: 10.1016/j.molcel.2019.04.008
Publication date: April 26, 2019
PMID: 31054975
Crystal structure of human RIOK2 bound to a specific inhibitor
Wang J, Varin T, Vieth M, Elkins JM
Open Biology 9:190037- . doi: 10.1098/rsob.190037
Publication date: April 26, 2019
PMID: 30991936
Discovery of selective activators of PRC2 mutant EED-I363M.
Suh JL, Barnash KD, Abramyan TM, Li F, The J, Engelberg IA, Vedadi M, Brown PJ, Kireev DB, Arrowsmith CH, James LI, Frye SV
Sci Rep 9(1):6524 . doi: 10.1038/s41598-019-43005-z
Publication date: April 25, 2019
PMID: 31024026
A chemical toolbox for the study of bromodomains and epigenetic signaling.
Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S
Nat Commun 10(1):1915 . doi: 10.1038/s41467-019-09672-2
Publication date: April 23, 2019
PMID: 31015424
Structural analyses reveal that MBD3 is a methylated-CG binder.
Liu K, Lei M, Wu Z, Gan B, Cheng H, Li Y, Min J
FEBS J. . doi: 10.1111/febs.14850
Publication date: April 13, 2019
PMID: 30980593
Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.
Zhang H, Dong C, Li L, Wasney GA, Min J
Nucleic Acids Res. . doi: 10.1093/nar/gkz269
Publication date: April 12, 2019
PMID: 30976796
Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function.
Walker BC, Tempel W, Zhu H, Park HW, Cochran JC
Biochemistry . doi: 10.1021/acs.biochem.9b00011
Publication date: April 11, 2019
PMID: 30973712
Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition.
Giordano, A; Forte, G; Terracciano, S; Russo, A; Sala, M; Scala, MC; Johansson, C; Oppermann, U; Riccio, R; Bruno, I; Di Micco, S;
ACS Medicinal Chemistry Letters 10:601-605 . doi: 10.1021/acsmedchemlett.8b00589
Publication date: April 10, 2019
PMID: 30996803
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A
Cell Reports 27:387-399.e7 . doi: 10.1016/j.celrep.2019.03.061
Publication date: April 9, 2019
PMID: 30970244
Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma
Song Y, Park PMC, Wu L, Ray A, Picaud S, Li D, Wimalasena VK, Du T, Filippakopoulos P, Anderson KC, Qi J, Chauhan D
Leukemia . doi: 10.1038/s41375-019-0467-z
Publication date: April 8, 2019
PMID: 30962579
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.
Ebrahimi, A; Sevinç, K; Gürhan Sevinç, G; Cribbs, AP; Philpott, M; Uyulur, F; Morova, T; Dunford, JE; Göklemez, S; Arı, Ş; Oppermann, U; Önder, TT;
Nature Chemical Biology :- . doi: 10.1038/s41589-019-0264-z
Publication date: April 8, 2019
PMID: 30962627
A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase
Pfeiffer M, Johansson C, Krojer T, Kavanagh KL, Oppermann U, Nidetzky B
ACS Catalysis 9:2962-2968 . doi: 10.1021/acscatal.9b00064
Publication date: April 5, 2019
PMID: 30984471
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis
Sorrell FJ, Kilian LM, Elkins JM
Biochemical Journal 476:1037-1051 . doi: 10.1042/BCJ20180867
Publication date: April 4, 2019
PMID: 30858169
Simultaneous Detection of 13 Allergens in Thermally Processed Food Using Targeted LC-MS/MS Approach.
Ogura, T; Clifford, R; Oppermann, U;
Journal of AOAC INTERNATIONAL :- . doi: 10.5740/jaoacint.19-0060
Publication date: April 1, 2019
PMID: 30940287
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency
Muniz JRC, Szeto NW-S, Frise R, Lee WH, Wang X-S, Thöny B, Himmelreich N, Blau N, Hsiao K-J, Liu T-T, Gileadi O, Oppermann U, Von Delft F, Yue WW, Tang NL-S
Pathology 51:274-280 . doi: 10.1016/j.pathol.2018.11.011
Publication date: April 1, 2019
PMID: 30853107

March 2019

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.
Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA
Nat Commun 10(1):1436 . doi: 10.1038/s41467-019-09309-4
Publication date: March 29, 2019
PMID: 30926792
Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Paudel P, Zhang Q, Leung C, Greenberg HC, Guo Y, Chern YH, Dong A, Li Y, Vedadi M, Zhuang Z, Tong Y
Proc. Natl. Acad. Sci. U.S.A. . doi: 10.1073/pnas.1815027116
Publication date: March 26, 2019
PMID: 30914461
AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation.
Wang Z, Kang L, Zhang H, Huang Y, Fang L, Li M, Brown PJ, Arrowsmith CH, Li J, Wong J
Oncogene . doi: 10.1038/s41388-019-0790-x
Publication date: March 20, 2019
PMID: 30894683
Targeting the Small GTPase Superfamily through their Regulatory Proteins.
Gray, JL; von Delft, F; Brennan, P;
Angewandte Chemie International Edition :- . doi: 10.1002/anie.201900585
Publication date: March 14, 2019
PMID: 30869179
Divergent roles of prostacyclin and PGE2 in human tendinopathy.
Bergqvist, F; Carr, AJ; Wheway, K; Watkins, B; Oppermann, U; Jakobsson, P-J; Dakin, SG;
Arthritis Research 21:74- . doi: 10.1186/s13075-019-1855-5
Publication date: March 13, 2019
PMID: 30867043
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
Roberts, NA; Hilton, EN; Lopes, FM; Singh, S; Randles, MJ; Gardiner, NJ; Chopra, K; Coletta, R; Bajwa, Z; Hall, RJ; Yue, WW; Schaefer, F; Weber, S; Henriksson, R; Stuart, HM; Hedman, H; Newman, WG; Woolf, AS;
Kidney International :- . doi: 10.1016/j.kint.2018.11.040
Publication date: March 8, 2019
PMID: 30885509
Organizational innovation for developing new medicines that target aging and age-related conditions.
Ford, GA; Lord, JM; Ferguson, MA; Bountra, C; Le Couteur, DG;
Journals of Gerontology, Series A :- . doi: 10.1093/gerona/glz062
Publication date: March 6, 2019
PMID: 30838376
Design and characterization of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.
Harding RJ, Loppnau P, Ackloo S, Lemak A, Hutchinson A, Hunt B, Holehouse AS, Ho JC, Fan L, Toledo-Sherman L, Seitova A, Arrowsmith CH
J. Biol. Chem. . doi: 10.1074/jbc.RA118.007204
Publication date: March 6, 2019
PMID: 30842263
Alternative Angiogenesis Mechanisms in Uterine Fibroids Related to Heavy Menstrual Bleeding.
Subramaniam, KS; Tapmeier, TT; Wang, C-Y; O'Brien, D; Philpott, M; Manek, S; Lindenthal, B; Obendorf, M; de Leo, B; Hess-Stumpp, H; Zollner, TM; Macaulay, V; Kessler, B; Zondervan, KT; Oppermann, U; Harris, A; Becker, CM;
Reproductive Sciences 26:226A-227A . doi:
Publication date: March 1, 2019
PMID:
Presence of Amine Oxidase 3 and its Role in Peritoneal Endometriosis Lesions.
De Leo, B; Thezenas, ML; Zondervan, KT; Becker, CM; Zollner, TM; Laux-Biehlmann, A; Kessler, BM; Oppermann, U;
Reproductive Sciences 26:130A-130A . doi:
Publication date: March 1, 2019
PMID:

February 2019

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).
Asquith, CRM; Berger, B-T; Wan, J; Bennett, JM; Capuzzi, SJ; Crona, DJ; Drewry, DH; East, MP; Elkins, JM; Fedorov, O; Godoi, PH; Hunter, DM; Knapp, S; Müller, S; Torrice, CD; Wells, CI; Earp, HS; Willson, TM; Zuercher, WJ;
Journal of Medicinal Chemistry 62:2830-2836 . doi: 10.1021/acs.jmedchem.8b01213
Publication date: February 26, 2019
PMID: 30768268
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Schewe, M; Sun, H; Mert, Ü; Mackenzie, A; Pike, ACW; Schulz, F; Constantin, C; Vowinkel, KS; Conrad, LJ; Kiper, AK; Gonzalez, W; Musinszki, M; Tegtmeier, M; Pryde, DC; Belabed, H; Nazare, M; de Groot, BL; Decher, N; Fakler, B; Carpenter, EP; Tucker, SJ; Baukrowitz, T;
Science 363:875-880 . doi: 10.1126/science.aav0569
Publication date: February 22, 2019
PMID: 30792303
Structural insights into SETD3-mediated histidine methylation on β-actin.
Guo Q, Liao S, Kwiatkowski S, Tomaka W, Yu H, Wu G, Tu X, Min J, Drozak J, Xu C
Elife 8: . doi: 10.7554/eLife.43676
Publication date: February 20, 2019
PMID: 30785395
Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion.
Husić M, Barsyte-Lovejoy D, Lovejoy DA
Front Endocrinol (Lausanne) 10:22 . doi: 10.3389/fendo.2019.00022
Publication date: February 19, 2019
PMID: 30774623
Understanding Protein-Lipid Interactions of TRP Channels of the Polycystin Family, through MD Simulations and Structural Studies
Wang, Q; Hedger, G; Aryal, P; Grieben, M; Pike, ACW; Shi, J; Carpenter, EP; Sansom, MSP;
Biophysical Journal 116:534A-535A . doi: 10.1016/j.bpj.2018.11.2877
Publication date: February 15, 2019
PMID:
Response to: 'Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis' by Cutolo et al.
Aungier, S; Cartwright, AJ; Schwenzer, A; Marshall, J; Dyson, MR; Slavny, P; Parthiban, K; Karatt-Vellatt, A; Sahbudin, I; Culbert, E; Hextall, P; Clanchy, FI; Williams, R; Marsden, BD; Raza, K; Filer, A; Buckley, CD; McCafferty, J; Midwood, KS;
Annals of the Rheumatic Diseases :- . doi: 10.1136/annrheumdis-2019-215108
Publication date: February 12, 2019
PMID: 30755416
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.
Nikolaou, N; Gathercole, LL; Kirkwood, L; Dunford, JE; Hughes, BA; Gilligan, LC; Oppermann, U; Penning, TM; Arlt, W; Hodson, L; Tomlinson, JW;
Journal of Steroid Biochemistry and Molecular Biology 189:218-227 . doi: 10.1016/j.jsbmb.2019.02.002
Publication date: February 12, 2019
PMID: 30769091
Microglial inflammation and phagocytosis in Alzheimer's disease: potential therapeutic targets.
Nizami S, Hall-Roberts H, Warrier S, Cowley SA, Di Daniel E.
Br J Pharmacol . doi: https://doi.org/10.1111/bph.14618
Publication date: February 10, 2019
PMID: 30740661
A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.
Priestley RS, Cheung J, Murphy EJ, Ehebauer MT, Davis JB, Di Daniel E.
J Pharmacol Toxicol Methods 95:47-55 . doi: https://doi.org/10.1016/j.vascn.2018.11.003
Publication date: February 2, 2019
PMID: 30476623
Ideation and implementation of an open science drug discovery business model - M4K Pharma.
Morgan MR, Roberts OG, Edwards AM
Wellcome Open Res 3:154 . doi: 10.12688/wellcomeopenres.14947.1
Publication date: February 2, 2019
PMID: 30705971
Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
Aungier, SR; Cartwright, AJ; Schwenzer, A; Marshall, JL; Dyson, MR; Slavny, P; Parthiban, K; Karatt-Vellatt, A; Sahbudin, I; Culbert, E; Hextall, P; Clanchy, FI; Williams, R; Marsden, BD; Raza, K; Filer, A; Buckley, CD; McCafferty, J; Midwood, KS;
Annals of the Rheumatic Diseases 78:186-191 . doi: 10.1136/annrheumdis-2018-214294
Publication date: February 1, 2019
PMID: 30552174

January 2019

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA, Tatu U, Brown LE, Pizarro J, Cowen LE
Nat Commun 10(1):402 . doi: 10.1038/s41467-018-08248-w
Publication date: January 24, 2019
PMID: 30679438

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