Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. Read more about Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.
Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability. Read more about Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability.
The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery. Read more about The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Read more about Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Read more about Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers. Read more about Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Read more about Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors. Read more about Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Chemical probes and inhibitors of bromodomains outside the BET family. Read more about Chemical probes and inhibitors of bromodomains outside the BET family.
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement. Read more about Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.
