Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Read more about Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors. Read more about Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Chemical probes and inhibitors of bromodomains outside the BET family. Read more about Chemical probes and inhibitors of bromodomains outside the BET family.
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement. Read more about Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.
The BEACH-domain containing protein, Nbeal2, interacts with Dock7, Sec16a and Vac14. Read more about The BEACH-domain containing protein, Nbeal2, interacts with Dock7, Sec16a and Vac14.
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1. Read more about H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Read more about Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Read more about DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
---Inhibition of histone H3K27 demethylase selectively modulates inflammatory phenotypes of natural killer cells. Read more about ---Inhibition of histone H3K27 demethylase selectively modulates inflammatory phenotypes of natural killer cells.
A systematic analysis of atomic protein-ligand interactions in the PDB. Read more about A systematic analysis of atomic protein-ligand interactions in the PDB.
